|N-(4-氯苯基)-4-羟基-3-(4-(4-(三氟甲氧基)苯基)哌嗪-1-基)丁酰胺|CsnPharm

CAS No.: 2086257-77-2

Synonyms: VBIT-4

VBIT-4 is a voltage-dependent anion channel (VDAC) oligomerization inhibitor.

规格	价格	促销价格	库存	数量

400-920-2911

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400-920-2911

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描述VBIT-4 is a voltage-dependent anion channel (VDAC) oligomerization inhibitor that decreases mitochondrial DNA (mtDNA) release, type I interferon (IFN) signaling, neutrophil extracellular traps, and disease severity in a mouse model of systemic lupus erythematosus.
In vitro, VBIT-4 rapidly inhibits the loss of ATP, which is a consequence of its translocation to the plasma membrane caused by VDAC1 overexpression, in plVdac1-expressing INS-1 cells. In vivo, VBIT-4 prevents increases in water consumption and polyuria in the db/db mice, also counteracts VDAC1 overexpression, preventing mistargeting to the β cell surface under glucotoxic conditions. Through the prevention of VDAC1 gene expression, VBIT-4 may have disease-modifying actions.

实验方案

技术信息

CAS号	2086257-77-2	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C21H23ClF3N3O3	运输	蓝冰
分子量	457.87	别名	VBIT-4

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