CAS No.: 54301-15-4
安吖啶盐酸盐 Catalog No. CSN10306
Synonyms: m-AMSA hydrochloride;acridinyl anisidide hydrochloride;AMSA HCl
Amsacrine HCl is an antineoplastic agent which can intercalate into the DNA of tumor cells.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00002719 Leukemia Neut... more >>ropenia Collapse << Phase 3 Completed - Italy ... more >> Azienda Policlinico Umberto Primo Rome, Italy, 00161 Collapse << NCT00002658 Leukemia Neut... more >>ropenia Collapse << Phase 3 Unknown - United Kingdom ... more >> University of Wales College of Medicine Cardiff, Wales, United Kingdom, CF14 4XN Collapse << NCT01324063 Leukemia Phase 3 Completed - - - 更多
- 参考文献
- [1] Attia SM. Molecular cytogenetic evaluation of the mechanism of genotoxic potential of amsacrine and nocodazole in mouse bone marrow cells. J Appl Toxicol. 2013 Jun;33(6):426-33.
- [2] Thomas D, Hammerling BC, et al. Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action. Br J Pharmacol. 2004 Jun;142(3):485-94.
- [3] Thomas D, Hammerling BC, Wu K, Wimmer AB, Ficker EK, Kirsch GE, Kochan MC, Wible BA, Scholz EP, Zitron E, Kathöfer S, Kreye VA, Katus HA, Schoels W, Karle CA, Kiehn J. Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action. Br J Pharmacol. 2004 Jun;142(3):485-94
- [4] Jensen CG, Wilson WR, Bleumink AR. Effects of amsacrine and other DNA-intercalating drugs on nuclear and nucleolar structure in cultured V79 Chinese hamster cells and PtK2 rat kangaroo cells. Cancer Res. 1985 Feb;45(2):717-25
- [5] Attia SM. Molecular cytogenetic evaluation of the mechanism of genotoxic potential of amsacrine and nocodazole in mouse bone marrow cells. J Appl Toxicol. 2013 Jun;33(6):426-33
- [6] Lee YC, Chen YJ, Huang CH, Chang LS. Amsacrine-induced apoptosis of human leukemia U937 cells is mediated by the inhibition of AKT- and ERK-induced stabilization of MCL1. Apoptosis. 2017 Mar;22(3):406-420
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 54301-15-4 | 储存条件 |
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| 分子式 | C21H20ClN3O3S | 运输 | 蓝冰 | |
| 分子量 | 429.92 | 别名 | m-AMSA hydrochloride;acridinyl anisidide hydrochloride;AMSA HCl;M-AMSA HCl;CI-880 HCl;SN-11841 HCl;Amsacrine (hydrochloride);AMSA;m-AMSA;NSC 141549;acridinyl anisidide;Cains Acridine. US brand name: Amsa PD. Foreign brand names: Amekrin;Amsidine;Amsidyl;Lamasine. Abbreviations: AMSA;mAMSA. Code names: CI880;SN11841;盐酸胺苯吖啶;盐酸安吖啶 |
