CAS No.: 170449-18-0
N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride Catalog No. CSN25386
Synonyms: Tyrphostin AG-1478 hydrochloride;NSC 693255 hydrochloride;AG-1478 HCl
AG-1478 hydrochloride (Tyrphostin AG-1478 hydrochloride) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 hydrochloride has antiviral effects against HCV and encephalomyocarditis virus (EMCV).
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 参考文献
- [1] Bojko A, et al. The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells. Folia Histochem Cytobiol. 2012 Jul 5;50(2):186-95.
- [2] Li W, et al. EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice. Sci Rep. 2016 Apr 18;6:24580.
- [3] Akhtar S, et al. Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo. PLoS One. 2015 Jul 13;10(7):e0132215.
- [4] Dorobantu CM, et al. Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6402-6.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 170449-18-0 | 储存条件 |
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| 分子式 | C16H15Cl2N3O2 | 运输 | 蓝冰 | |
| 分子量 | 352.22 | 别名 | Tyrphostin AG-1478 hydrochloride;NSC 693255 hydrochloride;AG-1478 HCl;AG-1478 Hydrochloride;Tyrphostin |
