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CAS No.: 22662-39-1

雷夫尼特 Catalog No. CSN11828

Synonyms: 雷复尼特

Rafoxanide inhibits SPAK and OSR1, is a salicylanilide used as an antiparasitic agent.

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400-920-2911

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生物活性

实验方案

技术信息

生物活性

描述Rafoxanide, a veterinary antihelminthic drug, has shown antibacterial activity in vitro against Gram-positive bacteria. In the murine peritoneal sepsis model with Col-R (colistin-resistant) strains, rafoxanide plus CMS, compared with CMS alone, increased mouse survival to 53.8% and 73.3%, and reduced bacterial loads in tissues and blood between 2.34 and 4.99 log10 cfu/g or mL, respectively^[3]. Rafoxanide is commonly used as anti-helminthic medicine in veterinary medicine, a main compound of salicylanilide. Rafoxanide, as an inhibitor of BRAF V600E mutant protein, inhibits the growth of colorectal cancer, multiple myeloma, and skin cancer. Rafoxanide is used in veterinary medicine for the treatment of fascioliasis^[4]. Rafoxanide treatment inhibited tumor growth, with no significant side effects, in an MM (multiple myeloma) mouse xenograft model. Combination of rafoxanide with bortezomib or lenalidomide significantly induced synergistic cytotoxicity in MM cells^[5]. Rafoxanide was found to exhibit the highest cytotoxic effects (IC50: 1.09 µM for A375 and 1.31 µM for A431 cells). Rafoxanide (40 mg/kg, i.p.) exhibited significant antitumor activity, comparable to that of oxaliplatin (5 mg/kg, i.p.). The combined administration of rafoxanide and oxaliplatin produced a synergistic therapeutic effect^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.5974 mL
- 7.9871 mL
- 15.9742 mL
- 5 mM
- 0.3195 mL
- 1.5974 mL
- 3.1948 mL
- 10 mM
- 0.1597 mL
- 0.7987 mL
- 1.5974 mL

技术信息

CAS号

22662-39-1

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C19H11Cl2I2NO3

运输

蓝冰

分子量

626.01

别名

雷复尼特

溶解度

DMSO	240.0 mg/mL (383.4 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+30% PEG300+water	5 mg/mL	clear
PO	0.5% CMC-Na	50 mg/mL	suspension

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