生物活性

• 描述Dronedarone is an amiodarone-like benzofuran which lacks the iodine moiety and presents a methane sulfonyl group that decreases its lipophilicity, thus shortening the half-life and decreasing tissue accumulation. Dronedarone blocks multiple cardiac ion channels and β-adrenoceptors, presenting electrophysiological characteristics of all four Vaughan-Williams classes of antiarrhythmic drugs. Dronedarone was more effective than placebo in maintaining sinus rhythm in patients with paroxysmal and/or persistent AF and was also effective for ventricular rate control during AF (Atrial fibrillation) recurrences, providing incremental rate control on top of standard drugs in permanent AF^[3]. Dronedarone decreases the incidence of AF recurrence and the ventricular rate during recurrence. Dronedarone increases mortality in patients with permanent AF and those with moderate-severe heart failure, and should thus be avoided in these populations. Dronedarone is less effective than amiodarone but also has less toxicity^[4]. Furthermore, the beneficial effects of oral dronedarone on ventricular rate control were maintained during exercise and sustained with continued therapy. Oral dronedarone was generally well tolerated in the treatment of adult patients with AF and/or atrial flutter in clinical studies^[5].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01288352	Atrial Fibrillation ... more >> Stroke Collapse <<	Phase 4	Active, not recruiting	November 2019	Belgium ... more >> 14 Sites Different, Belgium Czech Republic 4 Sites Different, Czech Republic Denmark 2 Sites Different, Denmark France 2 Sites Different, France Germany 51 Sites Different, Germany Italy 12 Sites Different, Italy Netherlands 13 Sites Different, Netherlands Poland 5 Sites Different, Poland Spain 10 Sites Different, Spain Switzerland 5 Sites Different, Switzerland United Kingdom 22 Sites Different, United Kingdom Collapse <<
  NCT03607123	-	-	Active, not recruiting	July 4, 2022	China, Jiangsu ... more >> The First Affiliated Hospital of Nanjing Medical University Nanjing, Jiangsu, China, 201129 Collapse <<
  NCT00911508	Atrial Fibrillation ... more >> Arrhythmia Collapse <<	Not Applicable	Completed	-	-

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• 参考文献

• [1] Piccinni C, Raschi E, et al. Trends in antiarrhythmic drug use after marketing authorization of dronedarone: comparison between Emilia Romagna (Italy) and Sweden. Eur J Clin Pharmacol. 2013 Mar;69(3):715-20.

  [2] Benaim G, Paniz Mondolfi AE. The emerging role of amiodarone and dronedarone in Chagas disease. Nat Rev Cardiol. 2012 Oct;9(10):605-9.

  [3] Tamargo J, López-Farré A, Caballero R, Delpón E. Dronedarone. Drugs Today (Barc). 2011;47(2):109-133

  [4] Tadros R, Nattel S, Andrade JG. Dronedarone: Basic Pharmacology and Clinical Use. Card Electrophysiol Clin. 2016;8(2):453-465

  [5] Hoy SM, Keam SJ. Dronedarone. Drugs. 2009;69(12):1647-1663

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