CAS No.: 95635-56-6
雷诺嗪二盐酸化物 Catalog No. CSN12787
Synonyms: CVT 303 dihydrochloride;RS 43285;Ranolazine (hydrochloride)
Ranolazine 2HCl is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Undrovinas AI, Belardinelli L, et al. Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current. J Cardiovasc Electrophysiol. 2006 May;17 Suppl 1:S169-S177.
- [2] Belardinelli L, Shryock JC, et al. Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine. Heart. 2006 Jul;92 Suppl 4:iv6-iv14.
- [3] Keating GM. Ranolazine: a review of its use as add-on therapy in patients with chronic stable angina pectoris. Drugs. 2013 Jan;73(1):55-73
- [4] Wang WQ, Robertson C, Dhalla AK, Belardinelli L. Antitorsadogenic effects of ({+/-})-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits. J Pharmacol Exp Ther. 2008 Jun;325(3):875-81
- [5] Zacharowski K, Blackburn B, Thiemermann C. Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat. Eur J Pharmacol. 2001 Apr 20;418(1-2):105-10
- [6] Cassano V, Leo A, Tallarico M, Nesci V, Cimellaro A, Fiorentino TV, Citraro R, Hribal ML, De Sarro G, Perticone F, Sesti G, Russo E, Sciacqua A. Metabolic and Cognitive Effects of Ranolazine in Type 2 Diabetes Mellitus: Data from an in vivo Model. Nutrients. 2020 Jan 31;12(2):382
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 95635-56-6 | 储存条件 |
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| 分子式 | C24H35Cl2N3O4 | 运输 | 蓝冰 | |
| 分子量 | 500.46 | 别名 | CVT 303 dihydrochloride;RS 43285;Ranolazine (hydrochloride);CVT-303;Ranolazine;Ranexa;Latixa;Ranolazine Dihydrochloride;Ranolazine HCl;Ranolazine Hydrochloride;盐酸雷诺嗪;雷诺嗪 |
