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CAS No.: 134-62-3

N,N-Diethyl-m-toluamide (DEET)/避蚊胺 Catalog No. CSN12532

Synonyms: DEET;N,N-Diethyl-m-toluamide;NSC-33840

DEET is the most common active ingredient in insect repellents.

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技术信息

生物活性

描述DEET, the insect repellent (N,N-diethyl-3-methylbenzamide), is a multimodal compound that acts as a spatial repellent as well as an irritant (contact repellent). When blood was mixed either with 0.1 or 1% DEET, female southern house mosquitoes spent significantly less time feeding than the time spent feeding on blood mixed only with the solvent. DEET, permethrin, and, to a lesser extent, picaridin, act as feeding deterrents^[3]. DEET inhibits food ingestion by Drosophila melanogaster flies, and this repellency is mediated by bitter taste neurons in the proboscis. DEET contact chemorepellency is mediated exclusively by the tarsal segments of the legs and not the proboscis^[4]. DEET induces favorable repellency against insects by acting on the sensory nervous system. DEET side effects in humans involve new molecular targets including the cholinergic system, acetylcholinesterase (AChE), muscarinic M1 and M3 receptor and the participation of the second messenger nitric oxide (NO)^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00938379	Malaria Dengu... more >>e Japanese Encephalitis Collapse <<	Phase 3	Unknown	June 2011	Lao People's Democratic Republ... more >>ic Rural villages in Attepu and Sekong Provinces, Laos PDR Recruiting Pakse, Attepu, Lao People's Democratic Republic Contact: Vanessa Chen-Hussey, MSc 856 (0)21 353 408 ext 116 vanessa.chen-hussey@lshtm.ac.uk Principal Investigator: Vanessa Chen-Hussey, MSc Collapse <<
NCT02938975	Malaria	Phase 3	Not yet recruiting	June 2019	Tanzania ... more >> Ifakara Health Institute Not yet recruiting Bagamoyo, Tanzania, 74 Contact: Mercy Nyika +255788-720602 mnyika@ihi.or.tz Principal Investigator: Sarah J Moore, PhD Sub-Investigator: Daniel F Msellemu, MSc Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.2282 mL
- 26.1411 mL
- 52.2823 mL
- 5 mM
- 1.0456 mL
- 5.2282 mL
- 10.4565 mL
- 10 mM
- 0.5228 mL
- 2.6141 mL
- 5.2282 mL

技术信息

CAS号

134-62-3

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C12H17NO

运输

蓝冰

分子量

191.27

别名

DEET;N,N-Diethyl-m-toluamide;NSC-33840;避蚊胺

溶解度

DMSO	98.0 mg/mL (512.4 mM)
Water	2.0 mg/mL (10.5 mM) warming

动物实验配方

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N,N-Diethyl-m-toluamide (DEET)/避蚊胺 Catalog No. CSN12532

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