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CAS No.: 1642-54-2

枸橼酸二乙碳酰嗪 Catalog No. CSN10803

Synonyms: 枸橼酸乙胺嗪

Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism in filarial microfilaria and is highly specific for several parasites and does not contain any toxic metallic elements.

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生物活性

描述Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism in filarial microfilaria; is highly specific for several parasites and does not contain any toxic metallic elements^[2]. Diethylcarbamazine citrate (DEC) is also anti-inflammatory drug. The only effective anti-inflammatory dose was 50mg/kg to reduce the high levels of glucose, insulin and triglycerides in serum. DEC was not anti-obesity drug because the weights of body, liver and adipose tissues were not changed. In addition, the activity of COX (cyclooxygenase) in DEC treatment decreased significantly, while NF-κBp65 localization in nuclear extracts was obviously inhibited in 50mg/kg treated group^[3]. Within 10 s of an intravenous injection of DECC(diethylcarbamazine citrate) (2.5 to 10 mg/kg) there was hypotension, bradycardia and there were reductions in left ventricular and carotid artery dP/dt max. DECC (5 or 10 mg/kg) significantly inhibited prostaglandin F2alpha-induced increases in peak inspiratory intra-tracheal pressure without modifying its pulmonary hypertensive effect^[4]. The effect of S. equina ES (excretory-secretory) as antioxidant against rat HCC (hepatocellular carcinoma ), while DEC could modulate such effect when combined with it^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01905423	-	-	Completed	-	Indonesia ... more >> University of Indonesia, Department of Parasitology Jakarta, Java, Indonesia, 10430 Collapse <<
NCT01905423	-	-	Completed	-	-
NCT03676140	Trachoma Yaws... more >> Lymphatic Filariases Scabies Strongyloidiasis Collapse <<	Phase 3	Not yet recruiting	January 2019	-

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5548 mL
- 12.7741 mL
- 25.5482 mL
- 5 mM
- 0.5110 mL
- 2.5548 mL
- 5.1096 mL
- 10 mM
- 0.2555 mL
- 1.2774 mL
- 2.5548 mL

技术信息

CAS号

1642-54-2

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H29N3O8

运输

蓝冰

分子量

391.42

别名

枸橼酸乙胺嗪

溶解度

DMSO	93.0 mg/mL (237.6 mM)
Water	155.0 mg/mL (396.0 mM)

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