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CAS No.: 944547-46-0

Mycro 3 Catalog No. CSN25655

Mycro3 is a small-molecule inhibitor of Myc-Max dimerization. The average residual tumor of Pdx1-cre/KRAS* mice after Mycro3 treatment (100mg/kg, orally, daily for 2 months) is approximately 30%.

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400-920-2911

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述The proto-oncogene c-myc encodes a transcription factor c-Myc, which is of great importance in controlling cell growth and vitality^[1]. The heterodimerization of c-Myc with Myc-associated factor X (MAX) plays a critical role in the proliferation, transformation, and apoptosis. Mycro3 is a small-molecule inhibitor of Myc-Max dimerization and also inhibit c-Myc/Max/DNA binding^[2]. c-Myc has become an interesting and feasible target for novel therapies of a variety of human malignancies related to c-Myc, Mycro3 may be a novel and effective therapeutic agents to treat cancer. Mechanism: Mycro-3 is shown to bind one of the three discrete binding sites on the c-Myc bHLH-Zip domain^[3].
参考文献

[1] Thompson EB. The many roles of c-Myc in apoptosis. Annu Rev Physiol. 1998;60:575-600.
[2] Chen BJ, Wu YL, Tanaka Y, Zhang W. Small molecules targeting c-Myc oncogene: promising anti-cancer therapeutics. Int J Biol Sci. 2014;10(10):1084-1096.
[3] Chen BJ, Wu YL, Tanaka Y, Zhang W. Small molecules targeting c-Myc oncogene: promising anti-cancer therapeutics. Int J Biol Sci. 2014;10(10):1084-1096.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8980 mL
- 9.4898 mL
- 18.9797 mL
- 5 mM
- 0.3796 mL
- 1.8980 mL
- 3.7959 mL
- 10 mM
- 0.1898 mL
- 0.9490 mL
- 1.8980 mL

技术信息

CAS号

944547-46-0

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H17ClF2N6O4

运输

蓝冰

分子量

526.88

别名

溶解度

DMSO	100.0 mg/mL (189.8 mM)

动物实验配方

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