|(2R,2a'E,2a1'S,4Z,4'E,5S,6S,6'R,8'E,11'R,15'S,17a'R,20'R,20a'R)-2a1',20'-二羟基-4-(甲氧基亚氨基)-5,6',8',19'-四甲基-6-((E)-4-甲基戊-2-烯-2-基)-2a1',3,4,5,6,6',7',10',11',14',15',17a',20',20a'-十四氢-2'H,17'H-螺[吡喃-2,13'-[11,15]甲桥[1,5]二氧杂环十八并[9,8,7-cd]苯并呋喃]-17'-酮|CsnPharm

CAS No.: 113507-06-5

Moxidectin/莫西菌素 Catalog No. CSN11476

Synonyms: CL301423;23-Methoxime-LL-F 28249α;Cydectin

Moxidectin is an anthelmintic drug which kills parasitic worms (helminths), and is used for the prevention and control of heartworm and intestinal worms.

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描述Moxidectin is an anthelmintic drug which kills parasitic worms (helminths), and is used for the prevention and control of heartworm and intestinal worms. Usually when parasite populations are ML-resistant (Macrocyclic lactone), MOX (Moxidectin) is more effective than avermectins. MOX may have higher intrinsic potency against some parasites, especially filarial nematodes, than the avermectins^[3]. Moxidectin is routinely used to treat gastrointestinal nematode infections and prevent heartworm disease caused by Dirofilaria immitis. Concurrent topical administration of a fluralaner plus moxidectin and a praziquantel product did not result in adverse findings. The concurrent treatment of cats with fluralaner plus moxidectin and praziquantel at the maximum dose in clinical use was well tolerated^[4]. Increasing both the dose and the number of dosages of moxidectin improved efficacy, with 100% protection obtained using three dosages of moxidectin at either 40 µg/kg (JYD-34, ZoeMO) or 60 µg/kg (ZoeLA). Three dosages of 24 µg/kg were also highly effective, providing ≥ 98.8% efficacy for all three strains^[5]. A single topical application of the fixed combination of fluralaner plus moxidectin to cats reduced the mean mite counts by 100%. Single topical application of the fixed combination of fluralaner plus moxidectin was highly effective against O. cynotis infestations in cats^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00751764	Infection	Phase 1	Completed	-	United Kingdom ... more >> Plymouth, United Kingdom, PL6 5HH Collapse <<
NCT03501251	Trichuris Trichiura; Infection	Phase 2	Completed	-	Tanzania ... more >> Public Health Laboratory Ivo de Carneri, P.O. Box 122 Chake Chake, Pemba, Tanzania Collapse <<
NCT00736697	Infection	Phase 1	Completed	-	France ... more >> Poitiers, France, 86000 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.5629 mL
- 7.8147 mL
- 15.6294 mL
- 5 mM
- 0.3126 mL
- 1.5629 mL
- 3.1259 mL
- 10 mM
- 0.1563 mL
- 0.7815 mL
- 1.5629 mL

技术信息

CAS号

113507-06-5

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C37H53NO8

运输

蓝冰

分子量

639.82

别名

CL301423;23-Methoxime-LL-F 28249α;Cydectin;Equest;ProHeart 6;Quest;Quest (parasiticide);Vetdectin Oral Drench;莫昔克丁

溶解度

DMSO	77.5 mg/mL (121.1 mM)
Water	insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00751764	Infection	Phase 1	Completed	-	United Kingdom ... more >> Plymouth, United Kingdom, PL6 5HH Collapse <<
NCT03501251	Trichuris Trichiura; Infection	Phase 2	Completed	-	Tanzania ... more >> Public Health Laboratory Ivo de Carneri, P.O. Box 122 Chake Chake, Pemba, Tanzania Collapse <<
NCT00736697	Infection	Phase 1	Completed	-	France ... more >> Poitiers, France, 86000 Collapse <<
NCT00300768	Onchocerciasis	Phase 2	Completed	-	Ghana ... more >> Onchocerciasis Chemotherapy Research Center Hohoe, Volta Region, Ghana Collapse <<
NCT00856362	Healthy	Phase 1	Completed	-	Germany ... more >> Berlin, Germany, 10117 Collapse <<
NCT00790998	Onchocerciasis	Phase 3	Completed	-	Congo, The Democratic Republic... more >> of the Centre de Recherche Clinique de Butembo - Université Catholique du Graben Butembo, Congo, The Democratic Republic of the Centre de Recherche en Maladies Tropicales de l'Ituri Rethy, Congo, The Democratic Republic of the Ghana Onchocerciasis Chemotherapy Research Center Hohoe, Ghana Liberia Liberian Institute for Biomedical Research Clinical Research Center Bolahun, Lofa County, Liberia Collapse <<
NCT01035619	Onchocerciasis	Phase 2	Withdrawn	-	-
NCT03012828	QT Effects in Healthy Voluntee... more >>rs Collapse <<	Phase 1	Completed	-	United States, Wisconsin ... more >> Spaulding Clinical West Bend, Wisconsin, United States, 53095 Collapse <<

Moxidectin/莫西菌素 Catalog No. CSN11476

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