生物活性

• 描述Morin, a natural product isolated and purified from the root bark of Morus alba L., induces caspase-dependent apoptosis through extrinsic pathway by upregulating Fas receptor as well as through the intrinsic pathway by modulating Bcl-2 and IAP family members, and ROS generation.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02064517	Clinical and Radiographic Succ... more >>ess in 24 Months Collapse <<	Phase 2	Recruiting	June 2020	France ... more >> CHRU de Brest - Pôle Organe des Sens Recruiting Brest, France, 29609 Contact: Reza ARBAB-CHIRANI, PU-PH       reza.arbabchirani@chu-brest.fr    Contact: Valérie CHEVALIER, MD       valerie.chevalier@chu-brest.fr    Principal Investigator: Reza ARBAB-CHIRANI, PU-PH          Sub-Investigator: Valérie CHEVALIER-HERISSET, MCU-PH          Sub-Investigator: Frédérique D'ARBONNEAU, MCU-PH          Sub-Investigator: Hervé FORAY, MCU-PH          Sub-Investigator: Karen VALLEYS, PH          Sub-Investigator: Valérie ARMENGOL, MCU-PH          Hôtel Dieu Recruiting Nantes, France, 44000 Contact: Fabienne PEREZ, PU-PH          Principal Investigator: Fabienne PEREZ, PU-PH          Sub-Investigator: Sylvie DAJEAN-TRUTAUD, MCU-PH          Sub-Investigator: Serena LOPEZ-CAZAUX, MCU-PH          Sub-Investigator: Elisabeth ROY, MCU-PH          Sub-Investigator: Alexis GAUDIN, MCU-PH          CHU de Rennes Not yet recruiting Rennes, France, 35000 Contact: Jean-Louis SIXIOU, PU-PH          Principal Investigator: Jean-Louis SIXIOU, PU-PH          Sub-Investigator: Alexia MARIE-COUSIN, MCU-PH          Sub-Investigator: Anne DAUTEL, MCU-PH          Sub-Investigator: Justine LE CLERC, AHU          Sub-Investigator: Sabrina LEMARECHAL, AU-PH          Sub-Investigator: Carole MORIN, AHU          Sub-Investigator: Matthieu PERARD, PH          Sub-Investigator: Yann-Loïg TURPIN, MCU-PH Collapse <<
  NCT02827214	-	-	Recruiting	October 2022	-
  NCT02464501	Peripheral Arterial Disease ... more >> Cardiovascular Disease Peripheral Vascular Disease Collapse <<	Not Applicable	Recruiting	June 2020	United States, Alabama ... more >> Cardiology Associates Recruiting Fairhope, Alabama, United States, 36532 Contact: Mary Austin, RN    251-990-1936    MAustin@cardassoc.com    Principal Investigator: Frank T. Bunch, MD, FACC          United States, Florida First Coast Cardiovascular Institute Recruiting Jacksonville, Florida, United States, 32256 Contact: Mary Hudson, RN    904-493-3333    mhudson@firstcoastcardio.com    Principal Investigator: Yazan Khatib, MD          Coastal Vascular and Interventional Recruiting Pensacola, Florida, United States, 32504 Contact: Angela MacKay, RN, MSN    850-494-1108    angela.mackay@coastalvi.com    Principal Investigator: Huey McDaniel, MD          United States, Iowa Vascular Institute of the Midwest Recruiting Davenport, Iowa, United States, 52807 Contact: Laura Shiltz, RN    563-324-3818    laura.shiltz@vimidwest.com    Principal Investigator: Eric Dippel, MD          United States, Louisiana Cardiovascular Institute of the South Recruiting Houma, Louisiana, United States, 70361 Contact: Deanna K Benoit, LPN    985-873-5613    Deanna.Benoit@cardio.com    Principal Investigator: Craig M. Walker, MD, FACC          United States, Michigan Michigan Outpatient Vascular Institute Recruiting Dearborn, Michigan, United States, 48124 Contact: Anna Leyson-Fiel, BSN, RN    313-505-1296    ALeysonfiel@movidearborn.com    Principal Investigator: Elias Kassab, MD          St. John Hospital Recruiting Detroit, Michigan, United States, 48236 Contact: Rhonda Morin, RN    313-343-7536    Rhonda.Morin@stjohn.org    Principal Investigator: Thomas P. Davis, MD, FACC          Mid-Michigan Heart & Vascular Center Recruiting Saginaw, Michigan, United States, 48604 Contact: Ellen Mook, RN, BSN    989-249-6432    emook@mmhavc.com    Principal Investigator: John M McClure II, MD, FACC          United States, Mississippi Hattiesburg Clinic Completed Hattiesburg, Mississippi, United States, 39401 United States, North Carolina Novant Health Recruiting Charlotte, North Carolina, United States, 28204 Contact: Robert Burdon    704-264-1400    rburdon@novanthealth.org    Principal Investigator: Michael Miller, MD          United States, South Carolina Medical University of South Carolina Recruiting Charleston, South Carolina, United States, 29425 Contact: Christopher Drummond    843-792-1274    drummonc@musc.edu    Principal Investigator: Thomas Todoran, MD          United States, Tennessee University Surgical Associates Recruiting Chattanooga, Tennessee, United States, 37403 Contact: Laura Brown    423-778-7695    Laura.brown@universitysurgical.com    Principal Investigator: Mark Fugate, MD          Kore Cardiovascular Research Recruiting Jackson, Tennessee, United States, 38305 Contact: Donna Manns    731-512-0104    dmanns@koreresearch.com    Principal Investigator: Elie Hage-Korban, MD          United States, Texas Huntsville Memorial Hospital Recruiting Huntsville, Texas, United States, 77340 Contact: Kristen Terry, CCMA, CRC    903-723-8800 ext 2379    kristen.terry@graceresearchllc.com    Principal Investigator: Gaurav Aggarwala, MD          North Dallas Research Associates Recruiting McKinney, Texas, United States, 75069 Contact: Irfan Ullah, MBBS, CCRP    972-562-2345    irfan@ndresearch.com    Principal Investigator: Muhammad A Khan, MD          Cardiovascular Associates of East Texas Recruiting Tyler, Texas, United States, 75701 Contact: Elizabeth Olson    903-595-2283 ext 2105    eolson@caet.net    Principal Investigator: Jeffrey Carr, MD, FACC          Tyler Cardiovascular Consultants Recruiting Tyler, Texas, United States, 75701 Contact: Kevin Thornton, LVN    903-510-7295    kthornton@uthet.com    Principal Investigator: Frank Navetta, MD Collapse <<

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• 参考文献

• [1] Hyun HB, Lee WS, et al. The flavonoid morin from Moraceae induces apoptosis by modulation of Bcl-2 family members and Fas receptor in HCT 116 cells. Int J Oncol. 2015;46(6):2670-8.

  [2] Amin MU, Khurram M, et al. Antibiotic additive and synergistic action of rutin, morin and quercetin against methicillin resistant Staphylococcus aureus. BMC Complement Altern Med. 2015 Mar 12;15:59.