|6-羟基-2,2-二甲基-2H-苯并[h]苯并吡喃-5-羧酸甲酯|CsnPharm

CAS No.: 55481-88-4

Mollugin/大叶茜草素 Catalog No. CSN11462

Synonyms: Rubimaillin;大叶茜草素

Mollugin, a natural product isolated and purified from the roots of Rubia cordifolia L., may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Mollugin is a major bioactive component isolated from Rubia cordifolia L. Mollugin attenuated the LPS-induced expression of nitric oxide (NO), inducible nitric oxide synthase (iNOS), interleukin (IL)-1β and IL-6 but augmented the expression of tumor necrosis factor (TNF)-α^[3]. Mollugin induces cell death in a dose-dependent manner in primary and metastatic OSCCs (human oral squamous cell carcinoma cells). Mollugin-induced cell death involved apoptosis, characterized by the appearance of nuclear shrinkage, flow cytometric analysis of sub-G1 phase arrest, and annexin V-FITC and propidium iodide staining^[4]. Mollugin significantly inhibited the expression of an NF-κB reporter gene induced by tumor necrosis factor (TNF)-α in a dose-dependent manner. Moreover, mollugin inhibited TNF-α-induced phosphorylation and nuclear translocation of p65, phosphorylation and degradation of inhibitor of κB (IκBα), and IκB kinase (IKK) phosphorylation^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5173 mL
- 17.5866 mL
- 35.1733 mL
- 5 mM
- 0.7035 mL
- 3.5173 mL
- 7.0347 mL
- 10 mM
- 0.3517 mL
- 1.7587 mL
- 3.5173 mL

技术信息

CAS号	55481-88-4	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C17H16O4	运输	蓝冰
分子量	284.31	别名	Rubimaillin;大叶茜草素

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Mollugin/大叶茜草素 Catalog No. CSN11462

靶点选择性

请登录您的专属账户

确认信息