CAS No.: 1032350-13-2
MK-2206 2HCl Catalog No. CSN15705
Synonyms: MK-2206 (2HCl);MK-2206 (hydrochloride);MK-2206
MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively, showing no inhibitory activities against 250 other protein kinases observed.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 Akt1
IC50:8nMAkt2
IC50:12nMAkt3
IC50:65nM- 描述
- 作用机制
- 细胞研究
- Cell Data
- 更多
- 参考文献
- [1] Keane NA, Glavey SV, et al. AKT as a therapeutic target in multiple myeloma. Expert Opin Ther Targets. 2014 Aug;18(8):897-915.
- [2] MK-2206: A potent oral allosteric AKT inhibitor
- [3] Hirai H, Sootome H, et al. MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo. Mol Cancer Ther. 2010 Jul;9(7):1956-67.
- [4] Pal SK, Reckamp K, et al. Akt inhibitors in clinical development for the treatment of cancer. Expert Opin Investig Drugs. 2010 Nov;19(11):1355-66.
- [5] Meuillet EJ, et al. Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain. Curr Med Chem. 2011;18(18):2727-42.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1032350-13-2 | 储存条件 |
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| 分子式 | C25H23Cl2N5O | 运输 | 蓝冰 | |||||||||
| 分子量 | 480.39 | 别名 | MK-2206 (2HCl);MK-2206 (hydrochloride);MK-2206;MK2206 HCl;MK-2206 (2HCl | |||||||||
| 溶解度 |
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动物实验配方 |
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| Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
|---|
| 22RV1 | - | Growth Inhibition Assay | - | IC50=21.5685 μM | SANGER |
| 5637 | - | Growth Inhibition Assay | - | IC50=9.84984 μM | SANGER |
| 639-V | - | Growth Inhibition Assay | - | IC50=18.3354 μM | SANGER |
| 647-V | - | Growth Inhibition Assay | - | IC50=60.1347 μM | SANGER |
| 697 | - | Growth Inhibition Assay | - | IC50=1.37616 μM | SANGER |
| 769-P | - | Growth Inhibition Assay | - | IC50=32.3641 μM | SANGER |
| 786-0 | - | Growth Inhibition Assay | - | IC50=4.94673 μM | SANGER |
| 8305C | - | Growth Inhibition Assay | - | IC50=19.2286 μM | SANGER |
| 8505C | - | Growth Inhibition Assay | - | IC50=9.04232 μM | SANGER |
| 8-MG-BA | - | Growth Inhibition Assay | - | IC50=19.0646 μM | SANGER |
| A101D | - | Growth Inhibition Assay | - | IC50=9.99974 μM | SANGER |
| A204 | - | Growth Inhibition Assay | - | IC50=2.83872 μM | SANGER |
| A253 | - | Growth Inhibition Assay | - | IC50=18.7286 μM | SANGER |
| A2780 | - | Growth Inhibition Assay | - | IC50=128.988 μM | SANGER |
| A388 | - | Growth Inhibition Assay | - | IC50=11.3897 μM | SANGER |
| A3-KAW | - | Growth Inhibition Assay | - | IC50=80.2154 μM | SANGER |
| A427 | - | Growth Inhibition Assay | - | IC50=11.7093 μM | SANGER |
| A431 | 5 μM | Kinase Assay | 5 h | Suppresses the signaling of Akt and Erk | 20571069 |
| A431 | - | Growth Inhibition Assay | - | IC50=9.80238 μM | SANGER |
| A498 | - | Growth Inhibition Assay | - | IC50=6.81961 μM | SANGER |
| A4-Fuk | - | Growth Inhibition Assay | - | IC50=0.46868 μM | SANGER |
| A549 | - | Growth Inhibition Assay | - | IC50=10.3973 μM | SANGER |
| A673 | - | Growth Inhibition Assay | - | IC50=161.705 μM | SANGER |
| A704 | - | Growth Inhibition Assay | - | IC50=6.6306 μM | SANGER |
| ABC-1 | - | Growth Inhibition Assay | - | IC50=2.33253 μM | SANGER |
| ACN | - | Growth Inhibition Assay | - | IC50=9.53277 μM | SANGER |
| AGS | - | Growth Inhibition Assay | - | IC50=2.72137 μM | SANGER |
| ALL-PO | - | Growth Inhibition Assay | - | IC50=24.619 μM | SANGER |
| AM-38 | - | Growth Inhibition Assay | - | IC50=22.8689 μM | SANGER |
| AN3-CA | - | Growth Inhibition Assay | - | IC50=3.62456 μM | SANGER |
| AsPC-1 | - | Growth Inhibition Assay | - | IC50=0.22122 μM | SANGER |
| ATN-1 | - | Growth Inhibition Assay | - | IC50=4.44304 μM | SANGER |
| AU565 | - | Growth Inhibition Assay | - | IC50=6.96957 μM | SANGER |
| BALL-1 | - | Growth Inhibition Assay | - | IC50=126.23 μM | SANGER |
| BB30-HNC | - | Growth Inhibition Assay | - | IC50=11.7982 μM | SANGER |
| BB49-HNC | - | Growth Inhibition Assay | - | IC50=12.1177 μM | SANGER |
| BB65-RCC | - | Growth Inhibition Assay | - | IC50=17.0479 μM | SANGER |
| BCPAP | - | Growth Inhibition Assay | - | IC50=12.4749 μM | SANGER |
| BE-13 | - | Growth Inhibition Assay | - | IC50=344.167 μM | SANGER |
| Becker | - | Growth Inhibition Assay | - | IC50=5.86472 μM | SANGER |
| BEN | - | Growth Inhibition Assay | - | IC50=153.928 μM | SANGER |
| BFTC-905 | - | Growth Inhibition Assay | - | IC50=15.7694 μM | SANGER |
| BFTC-909 | - | Growth Inhibition Assay | - | IC50=6.30345 μM | SANGER |
| BHT-101 | - | Growth Inhibition Assay | - | IC50=0.52961 μM | SANGER |
| BHY | - | Growth Inhibition Assay | - | IC50=64.1245 μM | SANGER |
| BPH-1 | - | Growth Inhibition Assay | - | IC50=14.1664 μM | SANGER |
| BT-20 | - | Growth Inhibition Assay | - | IC50=5.21353 μM | SANGER |
| BT-474 | - | Growth Inhibition Assay | - | IC50=6.233 μM | SANGER |
| BT-549 | - | Growth Inhibition Assay | - | IC50=25.9011 μM | SANGER |
| BV-173 | - | Growth Inhibition Assay | - | IC50=1.81074 μM | SANGER |
| BxPC-3 | - | Growth Inhibition Assay | - | IC50=40.5686 μM | SANGER |
| C2BBe1 | - | Growth Inhibition Assay | - | IC50=231.905 μM | SANGER |
| C32 | - | Growth Inhibition Assay | - | IC50=18.4727 μM | SANGER |
| C-33-A | - | Growth Inhibition Assay | - | IC50=64.0957 μM | SANGER |
| C3A | - | Growth Inhibition Assay | - | IC50=311.802 μM | SANGER |
| C643 cells harbored HRAS (G13R+/−) | 3 μM | Growth Inhibition Assay | 5 d | IC50=0.27 μM | 21289267 |
| C8166 | - | Growth Inhibition Assay | - | IC50=278.506 μM | SANGER |
| Ca9-22 | - | Growth Inhibition Assay | - | IC50=139.833 μM | SANGER |
| CAKI-1 | - | Growth Inhibition Assay | - | IC50=48.2845 μM | SANGER |
| CAL-120 | - | Growth Inhibition Assay | - | IC50=14.7027 μM | SANGER |
| CAL-12T | - | Growth Inhibition Assay | - | IC50=28.1112 μM | SANGER |
| CAL-27 | - | Growth Inhibition Assay | - | IC50=5.46339 μM | SANGER |
| CAL-33 | - | Growth Inhibition Assay | - | IC50=7.66233 μM | SANGER |
| CAL-39 | - | Growth Inhibition Assay | - | IC50=4.72146 μM | SANGER |
| CAL-51 | - | Growth Inhibition Assay | - | IC50=12.0716 μM | SANGER |
| CAL-54 | - | Growth Inhibition Assay | - | IC50=1.71242 μM | SANGER |
| CAL-62 | - | Growth Inhibition Assay | - | IC50=80.095 μM | SANGER |
| CAL-72 | - | Growth Inhibition Assay | - | IC50=185.054 μM | SANGER |
| CAL-85-1 | - | Growth Inhibition Assay | - | IC50=18.2357 μM | SANGER |
| Calu-3 | - | Growth Inhibition Assay | - | IC50=4.24416 μM | SANGER |
| Calu-6 | - | Growth Inhibition Assay | - | IC50=43.2382 μM | SANGER |
| CAMA-1 | - | Growth Inhibition Assay | - | IC50=8.77146 μM | SANGER |
| CAPAN-1 | - | Growth Inhibition Assay | - | IC50=153.064 μM | SANGER |
| Capan-2 | - | Growth Inhibition Assay | - | IC50=160.553 μM | SANGER |
| CaR-1 | - | Growth Inhibition Assay | - | IC50=33.9822 μM | SANGER |
| CAS-1 | - | Growth Inhibition Assay | - | IC50=15.4184 μM | SANGER |
| Ca-Ski | - | Growth Inhibition Assay | - | IC50=12.9041 μM | SANGER |
| CCRF-CEM | - | Growth Inhibition Assay | - | IC50=243.795 μM | SANGER |
| CEM-R | 10 μM | Cytotoxic Assay | 48 h | IC50=3.3 μM | 22614243 |
| CEM-R | 4 μM | Function Assay | 4 h | Increases the amount of cleaved LC4A/B, a well-established autophagy marker | 22614243 |
| CEM-S | 10 μM | Cytotoxic Assay | 48 h | IC50=5.1 μM | 22614243 |
| CEM-S | 4 μM | Function Assay | 4 h | Increases the amount of cleaved LC5A/B, a well-established autophagy marker | 22614243 |
| CFPAC-1 | - | Growth Inhibition Assay | - | IC50=11.9782 μM | SANGER |
| CGTH-W-1 | - | Growth Inhibition Assay | - | IC50=21.7166 μM | SANGER |
| ChaGo-K-1 | - | Growth Inhibition Assay | - | IC50=49.4793 μM | SANGER |
| CHL-1 | - | Growth Inhibition Assay | - | IC50=6.80079 μM | SANGER |
| CHP-134 | - | Growth Inhibition Assay | - | IC50=26.3867 μM | SANGER |
| CHP-212 | - | Growth Inhibition Assay | - | IC50=13.9739 μM | SANGER |
| CNE-1 | 10 μM | Growth Inhibition Assay | 96 h | IC50=2.96 μM | 25336925 |
| CNE-2 | 10 μM | Growth Inhibition Assay | 96 h | IC50=4.53 μM | 25336925 |
| CNE-2 | 10 μM | Function Assay | 48 h | Induces cell cycle arrest at G1 | 25336925 |
| COLO-320-HSR | - | Growth Inhibition Assay | - | IC50=216.125 μM | SANGER |
| COLO-668 | - | Growth Inhibition Assay | - | IC50=71.8451 μM | SANGER |
| COLO-678 | - | Growth Inhibition Assay | - | IC50=201.45 μM | SANGER |
| COLO-679 | - | Growth Inhibition Assay | - | IC50=126.753 μM | SANGER |
| COLO-680N | - | Growth Inhibition Assay | - | IC50=272.527 μM | SANGER |
| COLO-684 | - | Growth Inhibition Assay | - | IC50=1.23725 μM | SANGER |
| COLO-741 | - | Growth Inhibition Assay | - | IC50=40.1304 μM | SANGER |
| COLO-792 | - | Growth Inhibition Assay | - | IC50=95.2564 μM | SANGER |
| COLO-800 | - | Growth Inhibition Assay | - | IC50=34.3647 μM | SANGER |
| COLO-824 | - | Growth Inhibition Assay | - | IC50=60.0719 μM | SANGER |
| COR-L105 | - | Growth Inhibition Assay | - | IC50=1.79737 μM | SANGER |
| COR-L23 | - | Growth Inhibition Assay | - | IC50=32.9073 μM | SANGER |
| COR-L88 | - | Growth Inhibition Assay | - | IC50=142.14 μM | SANGER |
| CP50-MEL-B | - | Growth Inhibition Assay | - | IC50=144.501 μM | SANGER |
| CTB-1 | - | Growth Inhibition Assay | - | IC50=1.2899 μM | SANGER |
| CTV-1 | - | Growth Inhibition Assay | - | IC50=13.345 μM | SANGER |
| CW-2 | - | Growth Inhibition Assay | - | IC50=21.6069 μM | SANGER |
| D-247MG | - | Growth Inhibition Assay | - | IC50=11.9663 μM | SANGER |
| D-263MG | - | Growth Inhibition Assay | - | IC50=6.45169 μM | SANGER |
| D-283MED | - | Growth Inhibition Assay | - | IC50=15.0111 μM | SANGER |
| D-392MG | - | Growth Inhibition Assay | - | IC50=117.398 μM | SANGER |
| D-423MG | - | Growth Inhibition Assay | - | IC50=2.41044 μM | SANGER |
| D-502MG | - | Growth Inhibition Assay | - | IC50=8.78629 μM | SANGER |
| D-566MG | - | Growth Inhibition Assay | - | IC50=8.04429 μM | SANGER |
| Daoy | - | Growth Inhibition Assay | - | IC50=36.6538 μM | SANGER |
| DB | - | Growth Inhibition Assay | - | IC50=30.4942 μM | SANGER |
| DBTRG-05MG | - | Growth Inhibition Assay | - | IC50=207.909 μM | SANGER |
| DEL | - | Growth Inhibition Assay | - | IC50=11.424 μM | SANGER |
| Detroit562 | - | Growth Inhibition Assay | - | IC50=16.7318 μM | SANGER |
| DJM-1 | - | Growth Inhibition Assay | - | IC50=23.5234 μM | SANGER |
| DK-MG | - | Growth Inhibition Assay | - | IC50=24.294 μM | SANGER |
| DMS-114 | - | Growth Inhibition Assay | - | IC50=3.62278 μM | SANGER |
| DMS-273 | - | Growth Inhibition Assay | - | IC50=1.51959 μM | SANGER |
| DOHH-2 | - | Growth Inhibition Assay | - | IC50=1.28203 μM | SANGER |
| DOK | - | Growth Inhibition Assay | - | IC50=3.22859 μM | SANGER |
| DoTc2-4510 | - | Growth Inhibition Assay | - | IC50=84.2185 μM | SANGER |
| DSH1 | - | Growth Inhibition Assay | - | IC50=9.2087 μM | SANGER |
| DU-145 | - | Growth Inhibition Assay | - | IC50=0.64745 μM | SANGER |
| DU-4475 | - | Growth Inhibition Assay | - | IC50=36.9033 μM | SANGER |
| ECC10 | - | Growth Inhibition Assay | - | IC50=3.93622 μM | SANGER |
| EFM-19 | - | Growth Inhibition Assay | - | IC50=0.4401 μM | SANGER |
| EFO-21 | - | Growth Inhibition Assay | - | IC50=38.9349 μM | SANGER |
| EFO-27 | - | Growth Inhibition Assay | - | IC50=9.16412 μM | SANGER |
| EGI-1 | - | Growth Inhibition Assay | - | IC50=4.37778 μM | SANGER |
| EKVX | - | Growth Inhibition Assay | - | IC50=12.0313 μM | SANGER |
| EM-2 | - | Growth Inhibition Assay | - | IC50=0.97939 μM | SANGER |
| EoL-1- | - | Growth Inhibition Assay | - | IC50=3.07058 μM | SANGER |
| EPLC-272H | - | Growth Inhibition Assay | - | IC50=1.17256 μM | SANGER |
| ES1 | - | Growth Inhibition Assay | - | IC50=1.24065 μM | SANGER |
| ES3 | - | Growth Inhibition Assay | - | IC50=2.49759 μM | SANGER |
| ES4 | - | Growth Inhibition Assay | - | IC50=23.4232 μM | SANGER |
| ES5 | - | Growth Inhibition Assay | - | IC50=0.34455 μM | SANGER |
| ES6 | - | Growth Inhibition Assay | - | IC50=29.8157 μM | SANGER |
| ES7 | - | Growth Inhibition Assay | - | IC50=29.1465 μM | SANGER |
| ES8 | - | Growth Inhibition Assay | - | IC50=2.49287 μM | SANGER |
| ESS-1 | - | Growth Inhibition Assay | - | IC50=8.88704 μM | SANGER |
| ETK-1 | - | Growth Inhibition Assay | - | IC50=5.21165 μM | SANGER |
| EW-1 | - | Growth Inhibition Assay | - | IC50=18.1382 μM | SANGER |
| EW-11 | - | Growth Inhibition Assay | - | IC50=4.41838 μM | SANGER |
| EW-13 | - | Growth Inhibition Assay | - | IC50=26.0274 μM | SANGER |
| EW-16 | - | Growth Inhibition Assay | - | IC50=3.21879 μM | SANGER |
| EW-18 | - | Growth Inhibition Assay | - | IC50=2.41939 μM | SANGER |
| EW-22 | - | Growth Inhibition Assay | - | IC50=6.19649 μM | SANGER |
| EW-3 | - | Growth Inhibition Assay | - | IC50=3.19529 μM | SANGER |
| FADU | - | Growth Inhibition Assay | - | IC50=297.51 μM | SANGER |
| FTC-133 | - | Growth Inhibition Assay | - | IC50=58.0969 μM | SANGER |
| FTC133 cells harbored PTEN (allele deletion and R130+) | 3 μM | Growth Inhibition Assay | 5 d | IC50=0.18 μM | 21289267 |
| G-401 | - | Growth Inhibition Assay | - | IC50=1.29795 μM | SANGER |
| G-402 | - | Growth Inhibition Assay | - | IC50=3.70711 μM | SANGER |
| GAK | - | Growth Inhibition Assay | - | IC50=253.002 μM | SANGER |
| GAMG | - | Growth Inhibition Assay | - | IC50=2.23845 μM | SANGER |
| GB-1 | - | Growth Inhibition Assay | - | IC50=7.54804 μM | SANGER |
| GCIY | - | Growth Inhibition Assay | - | IC50=12.5209 μM | SANGER |
| GCT | - | Growth Inhibition Assay | - | IC50=11.8228 μM | SANGER |
| GEO | 500 nM | Growth Inhibition Assay | 72 h | Inhibits cell growth | 24581231 |
| GI-1 | - | Growth Inhibition Assay | - | IC50=27.721 μM | SANGER |
| GI-ME-N | - | Growth Inhibition Assay | - | IC50=19.1546 μM | SANGER |
| GMS-10 | - | Growth Inhibition Assay | - | IC50=26.2353 μM | SANGER |
| GOTO | - | Growth Inhibition Assay | - | IC50=107.777 μM | SANGER |
| GP5d | - | Growth Inhibition Assay | - | IC50=7.48764 μM | SANGER |
| GR-ST | - | Growth Inhibition Assay | - | IC50=3.04611 μM | SANGER |
| GT3TKB | - | Growth Inhibition Assay | - | IC50=149.928 μM | SANGER |
| H4 | - | Growth Inhibition Assay | - | IC50=3.45626 μM | SANGER |
| H9 | - | Growth Inhibition Assay | - | IC50=0.38883 μM | SANGER |
| HAL-01 | - | Growth Inhibition Assay | - | IC50=0.6213 μM | SANGER |
| HC11 | 10 μM | Function Assay | 24 h | Inhibits β-casein and ADRP synthesis | 22426621 |
| HCC1187 | - | Growth Inhibition Assay | - | IC50=13.1912 μM | SANGER |
| HCC1395 | - | Growth Inhibition Assay | - | IC50=2.75187 μM | SANGER |
| HCC1419 | - | Growth Inhibition Assay | - | IC50=0.48892 μM | SANGER |
| HCC1569 | - | Growth Inhibition Assay | - | IC50=16.8337 μM | SANGER |
| HCC1806 | - | Growth Inhibition Assay | - | IC50=23.8709 μM | SANGER |
| HCC1937 | - | Growth Inhibition Assay | - | IC50=42.7843 μM | SANGER |
| HCC1954 | - | Growth Inhibition Assay | - | IC50=8.45104 μM | SANGER |
| HCC2157 | - | Growth Inhibition Assay | - | IC50=3.38179 μM | SANGER |
| HCC2218 | - | Growth Inhibition Assay | - | IC50=1.68225 μM | SANGER |
| HCC2998 | - | Growth Inhibition Assay | - | IC50=24.4885 μM | SANGER |
| HCC38 | - | Growth Inhibition Assay | - | IC50=401.593 μM | SANGER |
| HCC70 | - | Growth Inhibition Assay | - | IC50=0.59827 μM | SANGER |
| HCE-4 | - | Growth Inhibition Assay | - | IC50=166.845 μM | SANGER |
| HCE-T | - | Growth Inhibition Assay | - | IC50=4.41579 μM | SANGER |
| HCT-116 | - | Growth Inhibition Assay | - | IC50=137.217 μM | SANGER |
| HDLM-2 | - | Growth Inhibition Assay | - | IC50=294.409 μM | SANGER |
| HD-MY-Z | - | Growth Inhibition Assay | - | IC50=60.5294 μM | SANGER |
| HEC-1 | - | Growth Inhibition Assay | - | IC50=8.89866 μM | SANGER |
| HEL | - | Growth Inhibition Assay | - | IC50=309.983 μM | SANGER |
| H-EMC-SS | - | Growth Inhibition Assay | - | IC50=0.49939 μM | SANGER |
| HepG2 | 10 μM | Cytotoxic Assay | 24 h | Sensitizes resistant cells to the cytotoxic effect of sorafenib | 21205925 |
| HepG2 cell | 20 μM | Kinase Assay | 24 h | Downregulates the phosphorylation of AKT | 23797319 |
| HepG2 cell | 30 μM | Growth Inhibition Assay | 24 h | Inhibits cell growth | 23797319 |
| HepG2 cell | 20 μM | Apoptosis Assay | 24 h | Induces cell apoptosis | 23797319 |
| HGC-27 | - | Growth Inhibition Assay | - | IC50=0.56783 μM | SANGER |
| HH | - | Growth Inhibition Assay | - | IC50=0.30283 μM | SANGER |
| HL-60 | - | Growth Inhibition Assay | - | IC50=20.0941 μM | SANGER |
| HLE | - | Growth Inhibition Assay | - | IC50=105.282 μM | SANGER |
| HN | - | Growth Inhibition Assay | - | IC50=9.16628 μM | SANGER |
| HO-1-N-1 | - | Growth Inhibition Assay | - | IC50=4.942 μM | SANGER |
| HONE-1 | 10 μM | Growth Inhibition Assay | 96 h | IC50=3.37 μM | 25336925 |
| HONE-1 | 10 μM | Function Assay | 48 h | Induces cell cycle arrest at G1 | 25336925 |
| HOP-92 | - | Growth Inhibition Assay | - | IC50=0.87223 μM | SANGER |
| HOS | - | Growth Inhibition Assay | - | IC50=1.49558 μM | SANGER |
| HPAF-II | - | Growth Inhibition Assay | - | IC50=56.4073 μM | SANGER |
| Hs-578-T | - | Growth Inhibition Assay | - | IC50=2.11433 μM | SANGER |
| HSC-2 | - | Growth Inhibition Assay | - | IC50=40.9113 μM | SANGER |
| HSC-3 | - | Growth Inhibition Assay | - | IC50=83.3071 μM | SANGER |
| HT | - | Growth Inhibition Assay | - | IC50=0.63239 μM | SANGER |
| HT-1080 | - | Growth Inhibition Assay | - | IC50=20.5497 μM | SANGER |
| HT-1197 | - | Growth Inhibition Assay | - | IC50=30.0598 μM | SANGER |
| HT-1376 | - | Growth Inhibition Assay | - | IC50=25.6465 μM | SANGER |
| HT-144 | - | Growth Inhibition Assay | - | IC50=33.863 μM | SANGER |
| HT-29 | - | Growth Inhibition Assay | - | IC50=201.212 μM | SANGER |
| HT-3 | - | Growth Inhibition Assay | - | IC50=21.5631 μM | SANGER |
| HT55 | - | Growth Inhibition Assay | - | IC50=49.1474 μM | SANGER |
| HTC-C3 | - | Growth Inhibition Assay | - | IC50=83.4702 μM | SANGER |
| Hth7 cells harbored NRAS (Q61R+/−) | 3 μM | Growth Inhibition Assay | 5 d | IC50=4.5 μM | 21289267 |
| Hth74 | 3 μM | Growth Inhibition Assay | 5 d | IC50=2.19 μM | 21289267 |
| HuCCT1 | - | Growth Inhibition Assay | - | IC50=204.208 μM | SANGER |
| HuH-7 | - | Growth Inhibition Assay | - | IC50=3.09464 μM | SANGER |
| HuO-3N1 | - | Growth Inhibition Assay | - | IC50=68.3238 μM | SANGER |
| HuO9 | - | Growth Inhibition Assay | - | IC50=0.92751 μM | SANGER |
| HuP-T3 | - | Growth Inhibition Assay | - | IC50=16.6373 μM | SANGER |
| HuP-T4 | - | Growth Inhibition Assay | - | IC50=27.0879 μM | SANGER |
| IA-LM | - | Growth Inhibition Assay | - | IC50=54.6322 μM | SANGER |
| IGR-1 | - | Growth Inhibition Assay | - | IC50=295.659 μM | SANGER |
| IGROV-1 | - | Growth Inhibition Assay | - | IC50=0.55249 μM | SANGER |
| IST-MEL1 | - | Growth Inhibition Assay | - | IC50=86.8872 μM | SANGER |
| IST-MES1 | - | Growth Inhibition Assay | - | IC50=32.2897 μM | SANGER |
| IST-SL1 | - | Growth Inhibition Assay | - | IC50=347.401 μM | SANGER |
| JAR | - | Growth Inhibition Assay | - | IC50=79.0546 μM | SANGER |
| JEG-3 | - | Growth Inhibition Assay | - | IC50=14.6326 μM | SANGER |
| J-RT3-T3-5 | - | Growth Inhibition Assay | - | IC50=0.74403 μM | SANGER |
| JVM-2 | - | Growth Inhibition Assay | - | IC50=58.9506 μM | SANGER |
| JVM-3 | - | Growth Inhibition Assay | - | IC50=8.15268 μM | SANGER |
| K1 cells harbored PIK3CA (E542K+/+) | 3 μM | Growth Inhibition Assay | 5 d | IC50=0.52 μM | 21289267 |
| K-562 | - | Growth Inhibition Assay | - | IC50=383.36 μM | SANGER |
| KARPAS-299 | - | Growth Inhibition Assay | - | IC50=86.1977 μM | SANGER |
| KARPAS-45 | - | Growth Inhibition Assay | - | IC50=0.37321 μM | SANGER |
| KAT18 | 3 μM | Growth Inhibition Assay | 5 d | IC50=4.62 μM | 21289267 |
| KE-37 | - | Growth Inhibition Assay | - | IC50=0.5826 μM | SANGER |
| KG-1 | - | Growth Inhibition Assay | - | IC50=17.6937 μM | SANGER |
| KGN | - | Growth Inhibition Assay | - | IC50=64.5514 μM | SANGER |
| KINGS-1 | - | Growth Inhibition Assay | - | IC50=24.4874 μM | SANGER |
| KLE | - | Growth Inhibition Assay | - | IC50=4.70198 μM | SANGER |
| KM12 | - | Growth Inhibition Assay | - | IC50=45.9076 μM | SANGER |
| KM-H2 | - | Growth Inhibition Assay | - | IC50=18.5232 μM | SANGER |
| KNS-42 | - | Growth Inhibition Assay | - | IC50=216.574 μM | SANGER |
| KNS-62 | - | Growth Inhibition Assay | - | IC50=3.63338 μM | SANGER |
| KNS-81-FD | - | Growth Inhibition Assay | - | IC50=12.5869 μM | SANGER |
| KOSC-2 | - | Growth Inhibition Assay | - | IC50=17.6757 μM | SANGER |
| KP-N-YN | - | Growth Inhibition Assay | - | IC50=341.123 μM | SANGER |
| KP-N-YS | - | Growth Inhibition Assay | - | IC50=89.9028 μM | SANGER |
| KS-1 | - | Growth Inhibition Assay | - | IC50=2.38191 μM | SANGER |
| KU-19-19 | - | Growth Inhibition Assay | - | IC50=22.1697 μM | SANGER |
| KU812 | - | Growth Inhibition Assay | - | IC50=158.674 μM | SANGER |
| KURAMOCHI | - | Growth Inhibition Assay | - | IC50=36.1198 μM | SANGER |
| KY821 | - | Growth Inhibition Assay | - | IC50=84.0892 μM | SANGER |
| KYSE-140 | - | Growth Inhibition Assay | - | IC50=12.8595 μM | SANGER |
| KYSE-150 | - | Growth Inhibition Assay | - | IC50=191.888 μM | SANGER |
| KYSE-180 | - | Growth Inhibition Assay | - | IC50=77.5454 μM | SANGER |
| KYSE-270 | - | Growth Inhibition Assay | - | IC50=20.0217 μM | SANGER |
| KYSE-410 | - | Growth Inhibition Assay | - | IC50=91.4042 μM | SANGER |
| KYSE-450 | - | Growth Inhibition Assay | - | IC50=151.539 μM | SANGER |
| KYSE-510 | - | Growth Inhibition Assay | - | IC50=21.6095 μM | SANGER |
| KYSE-520 | - | Growth Inhibition Assay | - | IC50=48.4016 μM | SANGER |
| KYSE-70 | - | Growth Inhibition Assay | - | IC50=70.7835 μM | SANGER |
| L-363 | - | Growth Inhibition Assay | - | IC50=0.83442 μM | SANGER |
| L-428 | - | Growth Inhibition Assay | - | IC50=297.616 μM | SANGER |
| LAMA-84 | - | Growth Inhibition Assay | - | IC50=4.14191 μM | SANGER |
| LAN-6 | - | Growth Inhibition Assay | - | IC50=10.2164 μM | SANGER |
| LB1047-RCC | - | Growth Inhibition Assay | - | IC50=2.24317 μM | SANGER |
| LB2241-RCC | - | Growth Inhibition Assay | - | IC50=0.99734 μM | SANGER |
| LB2518-MEL | - | Growth Inhibition Assay | - | IC50=135.993 μM | SANGER |
| LB771-HNC | - | Growth Inhibition Assay | - | IC50=8.64696 μM | SANGER |
| LB831-BLC | - | Growth Inhibition Assay | - | IC50=65.8481 μM | SANGER |
| LB996-RCC | - | Growth Inhibition Assay | - | IC50=8.53257 μM | SANGER |
| LC-2-ad | - | Growth Inhibition Assay | - | IC50=39.5512 μM | SANGER |
| LCLC-103H | - | Growth Inhibition Assay | - | IC50=70.6705 μM | SANGER |
| LCLC-97TM1 | - | Growth Inhibition Assay | - | IC50=20.8134 μM | SANGER |
| LK-2 | - | Growth Inhibition Assay | - | IC50=21.5953 μM | SANGER |
| LN229 | 0.5 μM | Apoptosis Assay | 60 h | Augments apoptogenic effects of gefitinib | 22057914 |
| LN-405 | - | Growth Inhibition Assay | - | IC50=6.79672 μM | SANGER |
| LNCaP-Clone-FGC | - | Growth Inhibition Assay | - | IC50=0.61048 μM | SANGER |
| LoVo | - | Growth Inhibition Assay | - | IC50=1.32534 μM | SANGER |
| LOXIMVI | - | Growth Inhibition Assay | - | IC50=17.0707 μM | SANGER |
| LS-1034 | - | Growth Inhibition Assay | - | IC50=246.266 μM | SANGER |
| LS-123 | - | Growth Inhibition Assay | - | IC50=9.31761 μM | SANGER |
| LS-411N | - | Growth Inhibition Assay | - | IC50=61.3903 μM | SANGER |
| LS-513 | - | Growth Inhibition Assay | - | IC50=2.33484 μM | SANGER |
| LU-134-A | - | Growth Inhibition Assay | - | IC50=3.88428 μM | SANGER |
| LU-135 | - | Growth Inhibition Assay | - | IC50=367.035 μM | SANGER |
| LU-139 | - | Growth Inhibition Assay | - | IC50=33.6605 μM | SANGER |
| LU-65 | - | Growth Inhibition Assay | - | IC50=304.32 μM | SANGER |
| LU-99A | - | Growth Inhibition Assay | - | IC50=7.14322 μM | SANGER |
| LXF-289 | - | Growth Inhibition Assay | - | IC50=1.17156 μM | SANGER |
| M059J | - | Growth Inhibition Assay | - | IC50=17.703 μM | SANGER |
| M14 | - | Growth Inhibition Assay | - | IC50=23.4088 μM | SANGER |
| MC116 | - | Growth Inhibition Assay | - | IC50=75.5708 μM | SANGER |
| MCF7 | - | Growth Inhibition Assay | - | IC50=2.86117 μM | SANGER |
| MC-IXC | - | Growth Inhibition Assay | - | IC50=7.48576 μM | SANGER |
| MDA-MB-157 | - | Growth Inhibition Assay | - | IC50=9.92878 μM | SANGER |
| MDA-MB-175-VII | - | Growth Inhibition Assay | - | IC50=0.13738 μM | SANGER |
| MDA-MB-231 | - | Growth Inhibition Assay | - | IC50=177.503 μM | SANGER |
| MDA-MB-361 | - | Growth Inhibition Assay | - | IC50=0.57761 μM | SANGER |
| MDA-MB-415 | - | Growth Inhibition Assay | - | IC50=0.63626 μM | SANGER |
| MDA-MB-453 | - | Growth Inhibition Assay | - | IC50=16.1642 μM | SANGER |
| ME-180 | - | Growth Inhibition Assay | - | IC50=1.56891 μM | SANGER |
| MEG-01 | - | Growth Inhibition Assay | - | IC50=11.7509 μM | SANGER |
| MEL-HO | - | Growth Inhibition Assay | - | IC50=5.37336 μM | SANGER |
| Mewo | - | Growth Inhibition Assay | - | IC50=71.505 μM | SANGER |
| MFE-280 | - | Growth Inhibition Assay | - | IC50=0.96465 μM | SANGER |
| MFM-223 | - | Growth Inhibition Assay | - | IC50=1.34461 μM | SANGER |
| MG-63 | - | Growth Inhibition Assay | - | IC50=39.3424 μM | SANGER |
| MHH-ES-1 | - | Growth Inhibition Assay | - | IC50=58.4814 μM | SANGER |
| MHH-NB-11 | - | Growth Inhibition Assay | - | IC50=17.9673 μM | SANGER |
| MHH-PREB-1 | - | Growth Inhibition Assay | - | IC50=3.72038 μM | SANGER |
| MIA-PaCa-2 | - | Growth Inhibition Assay | - | IC50=20.6883 μM | SANGER |
| MKN7 | - | Growth Inhibition Assay | - | IC50=56.0285 μM | SANGER |
| ML-2 | - | Growth Inhibition Assay | - | IC50=121.676 μM | SANGER |
| MLMA | - | Growth Inhibition Assay | - | IC50=4.02966 μM | SANGER |
| MN-60 | - | Growth Inhibition Assay | - | IC50=2.29923 μM | SANGER |
| MOLT-13 | - | Growth Inhibition Assay | - | IC50=342.326 μM | SANGER |
| MOLT-16 | - | Growth Inhibition Assay | - | IC50=0.3032 μM | SANGER |
| MOLT-4 | 10 μM | Cytotoxic Assay | 48 h | IC50=1.7 μM | 22614243 |
| MOLT-4 | 10 μM | Function Assay | 24 h | Blocks cells in the G0/G1 phase of the cell cycle | 22614243 |
| MOLT-4 | 4 μM | Function Assay | 4 h | Increases the amount of cleaved LC3A/B, a well-established autophagy marker | 22614243 |
| MOLT-4 | - | Growth Inhibition Assay | - | IC50=0.80582 μM | SANGER |
| Mo-T | - | Growth Inhibition Assay | - | IC50=20.1665 μM | SANGER |
| MPP-89 | - | Growth Inhibition Assay | - | IC50=25.0458 μM | SANGER |
| MS-1 | - | Growth Inhibition Assay | - | IC50=14.9611 μM | SANGER |
| MSTO-211H | - | Growth Inhibition Assay | - | IC50=7.67336 μM | SANGER |
| MV-4-11 | - | Growth Inhibition Assay | - | IC50=2.75266 μM | SANGER |
| MZ1-PC | - | Growth Inhibition Assay | - | IC50=65.5649 μM | SANGER |
| MZ2-MEL | - | Growth Inhibition Assay | - | IC50=23.7759 μM | SANGER |
| MZ7-mel | - | Growth Inhibition Assay | - | IC50=178.467 μM | SANGER |
| NB10 | - | Growth Inhibition Assay | - | IC50=9.02224 μM | SANGER |
| NB12 | - | Growth Inhibition Assay | - | IC50=6.39071 μM | SANGER |
| NB13 | - | Growth Inhibition Assay | - | IC50=26.0949 μM | SANGER |
| NB14 | - | Growth Inhibition Assay | - | IC50=34.4684 μM | SANGER |
| NB17 | - | Growth Inhibition Assay | - | IC50=392.596 μM | SANGER |
| NB5 | - | Growth Inhibition Assay | - | IC50=4.53697 μM | SANGER |
| NB6 | - | Growth Inhibition Assay | - | IC50=270.1 μM | SANGER |
| NB69 | - | Growth Inhibition Assay | - | IC50=2.38983 μM | SANGER |
| NB7 | - | Growth Inhibition Assay | - | IC50=0.82411 μM | SANGER |
| NBsusSR | - | Growth Inhibition Assay | - | IC50=9.27402 μM | SANGER |
| NCI-H1048 | - | Growth Inhibition Assay | - | IC50=2.96865 μM | SANGER |
| NCI-H1092 | - | Growth Inhibition Assay | - | IC50=65.0095 μM | SANGER |
| NCI-H1155 | - | Growth Inhibition Assay | - | IC50=45.8967 μM | SANGER |
| NCI-H1299 | - | Growth Inhibition Assay | - | IC50=11.8093 μM | SANGER |
| NCI-H1304 | - | Growth Inhibition Assay | - | IC50=154.694 μM | SANGER |
| NCI-H1355 | - | Growth Inhibition Assay | - | IC50=20.3374 μM | SANGER |
| NCI-H1395 | - | Growth Inhibition Assay | - | IC50=2.18091 μM | SANGER |
| NCI-H1437 | - | Growth Inhibition Assay | - | IC50=74.4048 μM | SANGER |
| NCI-H1563 | - | Growth Inhibition Assay | - | IC50=0.48189 μM | SANGER |
| NCI-H1573 | - | Growth Inhibition Assay | - | IC50=43.3477 μM | SANGER |
| NCI-H1581 | - | Growth Inhibition Assay | - | IC50=85.4641 μM | SANGER |
| NCI-H1623 | - | Growth Inhibition Assay | - | IC50=3.41224 μM | SANGER |
| NCI-H1650 | - | Growth Inhibition Assay | - | IC50=22.764 μM | SANGER |
| NCI-H1651 | - | Growth Inhibition Assay | - | IC50=131.243 μM | SANGER |
| NCI-H1693 | - | Growth Inhibition Assay | - | IC50=6.63604 μM | SANGER |
| NCI-H1755 | - | Growth Inhibition Assay | - | IC50=25.9945 μM | SANGER |
| NCI-H1770 | - | Growth Inhibition Assay | - | IC50=125.514 μM | SANGER |
| NCI-H1792 | - | Growth Inhibition Assay | - | IC50=96.8992 μM | SANGER |
| NCI-H1793 | - | Growth Inhibition Assay | - | IC50=109.28 μM | SANGER |
| NCI-H1993 | - | Growth Inhibition Assay | - | IC50=342.365 μM | SANGER |
| NCI-H2029 | - | Growth Inhibition Assay | - | IC50=96.9566 μM | SANGER |
| NCI-H2052 | - | Growth Inhibition Assay | - | IC50=398.472 μM | SANGER |
| NCI-H2087 | - | Growth Inhibition Assay | - | IC50=131.483 μM | SANGER |
| NCI-H209 | - | Growth Inhibition Assay | - | IC50=100.121 μM | SANGER |
| NCI-H2122 | - | Growth Inhibition Assay | - | IC50=22.2432 μM | SANGER |
| NCI-H2170 | - | Growth Inhibition Assay | - | IC50=31.8516 μM | SANGER |
| NCI-H2228 | - | Growth Inhibition Assay | - | IC50=2.31552 μM | SANGER |
| NCI-H226 | - | Growth Inhibition Assay | - | IC50=27.4578 μM | SANGER |
| NCI-H2291 | - | Growth Inhibition Assay | - | IC50=14.5878 μM | SANGER |
| NCI-H23 | - | Growth Inhibition Assay | - | IC50=14.7997 μM | SANGER |
| NCI-H2342 | - | Growth Inhibition Assay | - | IC50=25.1953 μM | SANGER |
| NCI-H2347 | - | Growth Inhibition Assay | - | IC50=247.713 μM | SANGER |
| NCI-H2405 | - | Growth Inhibition Assay | - | IC50=23.2533 μM | SANGER |
| NCI-H2452 | - | Growth Inhibition Assay | - | IC50=122.21 μM | SANGER |
| NCI-H28 | - | Growth Inhibition Assay | - | IC50=7.2924 μM | SANGER |
| NCI-H292 | 3 μM | Cytotoxic Assay | 72 h | Inhibition of cell proliferation | 20571069 |
| NCI-H292 | - | Growth Inhibition Assay | - | IC50=4.38146 μM | SANGER |
| NCI-H441 | - | Growth Inhibition Assay | - | IC50=20.7379 μM | SANGER |
| NCI-H446 | - | Growth Inhibition Assay | - | IC50=5.20009 μM | SANGER |
| NCI-H460 | - | Growth Inhibition Assay | - | IC50=4.26443 μM | SANGER |
| NCI-H520 | - | Growth Inhibition Assay | - | IC50=0.98592 μM | SANGER |
| NCI-H522 | - | Growth Inhibition Assay | - | IC50=72.3413 μM | SANGER |
| NCI-H526 | - | Growth Inhibition Assay | - | IC50=22.3895 μM | SANGER |
| NCI-H596 | - | Growth Inhibition Assay | - | IC50=62.7496 μM | SANGER |
| NCI-H630 | - | Growth Inhibition Assay | - | IC50=332.294 μM | SANGER |
| NCI-H650 | - | Growth Inhibition Assay | - | IC50=202.103 μM | SANGER |
| NCI-H661 | - | Growth Inhibition Assay | - | IC50=22.034 μM | SANGER |
| NCI-H69 | - | Growth Inhibition Assay | - | IC50=441.083 μM | SANGER |
| NCI-H720 | - | Growth Inhibition Assay | - | IC50=0.37679 μM | SANGER |
| NCI-H727 | - | Growth Inhibition Assay | - | IC50=15.4221 μM | SANGER |
| NCI-H747 | - | Growth Inhibition Assay | - | IC50=3.20694 μM | SANGER |
| NCI-H810 | - | Growth Inhibition Assay | - | IC50=310.57 μM | SANGER |
| NCI-H82 | - | Growth Inhibition Assay | - | IC50=180.165 μM | SANGER |
| NCI-N87 | - | Growth Inhibition Assay | - | IC50=18.9008 μM | SANGER |
| NCI-SNU-1 | - | Growth Inhibition Assay | - | IC50=8.64643 μM | SANGER |
| NCI-SNU-5 | - | Growth Inhibition Assay | - | IC50=186.84 μM | SANGER |
| NEC8 | - | Growth Inhibition Assay | - | IC50=0.09651 μM | SANGER |
| NH-12 | - | Growth Inhibition Assay | - | IC50=17.3303 μM | SANGER |
| NKM-1 | - | Growth Inhibition Assay | - | IC50=0.86253 μM | SANGER |
| NMC-G1 | - | Growth Inhibition Assay | - | IC50=24.2226 μM | SANGER |
| no-10 | - | Growth Inhibition Assay | - | IC50=178.134 μM | SANGER |
| no-11 | - | Growth Inhibition Assay | - | IC50=10.4353 μM | SANGER |
| NOMO-1 | - | Growth Inhibition Assay | - | IC50=39.8274 μM | SANGER |
| NOS-1 | - | Growth Inhibition Assay | - | IC50=0.63723 μM | SANGER |
| NTERA-S-cl-D1 | - | Growth Inhibition Assay | - | IC50=57.778 μM | SANGER |
| NUGC-3 | - | Growth Inhibition Assay | - | IC50=26.2103 μM | SANGER |
| NY | - | Growth Inhibition Assay | - | IC50=165.314 μM | SANGER |
| OAW-28 | - | Growth Inhibition Assay | - | IC50=2.29951 μM | SANGER |
| OAW-42 | - | Growth Inhibition Assay | - | IC50=0.8872 μM | SANGER |
| OC-314 | - | Growth Inhibition Assay | - | IC50=2.15086 μM | SANGER |
| OCI-AML2 | - | Growth Inhibition Assay | - | IC50=31.069 μM | SANGER |
| OCUB-M | - | Growth Inhibition Assay | - | IC50=0.70966 μM | SANGER |
| OCUT1 cells harbored PIK3CA (H1047R+/+) | 3 μM | Growth Inhibition Assay | 5 d | IC50=0.14 μM | 21289267 |
| OE19 | - | Growth Inhibition Assay | - | IC50=15.1541 μM | SANGER |
| OE33 | - | Growth Inhibition Assay | - | IC50=34.2855 μM | SANGER |
| OMC-1 | - | Growth Inhibition Assay | - | IC50=1.74677 μM | SANGER |
| ONS-76 | - | Growth Inhibition Assay | - | IC50=11.636 μM | SANGER |
| OS-RC-2 | - | Growth Inhibition Assay | - | IC50=3.1119 μM | SANGER |
| OVCAR-3 | - | Growth Inhibition Assay | - | IC50=3.40786 μM | SANGER |
| OVCAR-4 | - | Growth Inhibition Assay | - | IC50=188.333 μM | SANGER |
| OVCAR-5 | - | Growth Inhibition Assay | - | IC50=10.2433 μM | SANGER |
| OVCAR-8 | - | Growth Inhibition Assay | - | IC50=145.636 μM | SANGER |
| P12-ICHIKAWA | - | Growth Inhibition Assay | - | IC50=0.1162 μM | SANGER |
| P30-OHK | - | Growth Inhibition Assay | - | IC50=3.80976 μM | SANGER |
| PA-1 | - | Growth Inhibition Assay | - | IC50=1.35265 μM | SANGER |
| PANC-03-27 | - | Growth Inhibition Assay | - | IC50=29.444 μM | SANGER |
| PANC-08-13 | - | Growth Inhibition Assay | - | IC50=81.1768 μM | SANGER |
| PANC-10-05 | - | Growth Inhibition Assay | - | IC50=77.4243 μM | SANGER |
| PC-14 | - | Growth Inhibition Assay | - | IC50=14.9654 μM | SANGER |
| PC-3 | - | Growth Inhibition Assay | - | IC50=11.5764 μM | SANGER |
| PFSK-1 | - | Growth Inhibition Assay | - | IC50=5.72732 μM | SANGER |
| PSN1 | - | Growth Inhibition Assay | - | IC50=45.2548 μM | SANGER |
| QIMR-WIL | - | Growth Inhibition Assay | - | IC50=1.49116 μM | SANGER |
| Ramos-2G6-4C10 | - | Growth Inhibition Assay | - | IC50=1.33701 μM | SANGER |
| RCC10RGB | - | Growth Inhibition Assay | - | IC50=28.5417 μM | SANGER |
| RCM-1 | - | Growth Inhibition Assay | - | IC50=214.762 μM | SANGER |
| RD | - | Growth Inhibition Assay | - | IC50=6.98284 μM | SANGER |
| RERF-LC-MS | - | Growth Inhibition Assay | - | IC50=276.007 μM | SANGER |
| RH-1 | - | Growth Inhibition Assay | - | IC50=12.2184 μM | SANGER |
| RH-18 | - | Growth Inhibition Assay | - | IC50=25.5918 μM | SANGER |
| RKO | - | Growth Inhibition Assay | - | IC50=1.87101 μM | SANGER |
| RMG-I | - | Growth Inhibition Assay | - | IC50=2.16398 μM | SANGER |
| RO82-W-1 | - | Growth Inhibition Assay | - | IC50=46.9822 μM | SANGER |
| RPMI-2650 | - | Growth Inhibition Assay | - | IC50=5.66199 μM | SANGER |
| RPMI-7951 | - | Growth Inhibition Assay | - | IC50=12.1854 μM | SANGER |
| RPMI-8226 | - | Growth Inhibition Assay | - | IC50=2.62953 μM | SANGER |
| RPMI-8866 | - | Growth Inhibition Assay | - | IC50=249.27 μM | SANGER |
| RS4-11 | - | Growth Inhibition Assay | - | IC50=0.3461 μM | SANGER |
| RT-112 | - | Growth Inhibition Assay | - | IC50=3.52388 μM | SANGER |
| RVH-421 | - | Growth Inhibition Assay | - | IC50=3.81788 μM | SANGER |
| RXF393 | - | Growth Inhibition Assay | - | IC50=2.60487 μM | SANGER |
| S-117 | - | Growth Inhibition Assay | - | IC50=23.7651 μM | SANGER |
| Saos-2 | - | Growth Inhibition Assay | - | IC50=5.8653 μM | SANGER |
| SAS | - | Growth Inhibition Assay | - | IC50=162.678 μM | SANGER |
| SBC-1 | - | Growth Inhibition Assay | - | IC50=0.44035 μM | SANGER |
| SBC-5 | - | Growth Inhibition Assay | - | IC50=386.985 μM | SANGER |
| SCC-15 | - | Growth Inhibition Assay | - | IC50=13.9775 μM | SANGER |
| SCC-25 | - | Growth Inhibition Assay | - | IC50=4.06566 μM | SANGER |
| SCC-4 | - | Growth Inhibition Assay | - | IC50=8.68219 μM | SANGER |
| SCC-9 | - | Growth Inhibition Assay | - | IC50=191 μM | SANGER |
| SCH | - | Growth Inhibition Assay | - | IC50=96.3877 μM | SANGER |
| SF126 | - | Growth Inhibition Assay | - | IC50=8.45936 μM | SANGER |
| SF268 | - | Growth Inhibition Assay | - | IC50=126.158 μM | SANGER |
| SF295 | - | Growth Inhibition Assay | - | IC50=5.80633 μM | SANGER |
| SF539 | - | Growth Inhibition Assay | - | IC50=10.9041 μM | SANGER |
| SH-4 | - | Growth Inhibition Assay | - | IC50=246.09 μM | SANGER |
| SHP-77 | - | Growth Inhibition Assay | - | IC50=9.39935 μM | SANGER |
| SiHa | - | Growth Inhibition Assay | - | IC50=15.7594 μM | SANGER |
| SJRH30 | - | Growth Inhibition Assay | - | IC50=3.69122 μM | SANGER |
| SJSA-1 | - | Growth Inhibition Assay | - | IC50=13.2327 μM | SANGER |
| SKG-IIIa | - | Growth Inhibition Assay | - | IC50=8.63069 μM | SANGER |
| Sk-Hep1 | 10 μM | Cytotoxic Assay | 24 h | Sensitizes resistant cells to the cytotoxic effect of sorafenib | 21205925 |
| SK-HEP-1 | - | Growth Inhibition Assay | - | IC50=69.9486 μM | SANGER |
| SK-LU-1 | - | Growth Inhibition Assay | - | IC50=16.6956 μM | SANGER |
| SK-MEL-1 | - | Growth Inhibition Assay | - | IC50=92.9106 μM | SANGER |
| SK-MEL-2 | - | Growth Inhibition Assay | - | IC50=23.8133 μM | SANGER |
| SK-MEL-3 | - | Growth Inhibition Assay | - | IC50=147.878 μM | SANGER |
| SK-MEL-30 | - | Growth Inhibition Assay | - | IC50=123.244 μM | SANGER |
| SK-MES-1 | - | Growth Inhibition Assay | - | IC50=16.8419 μM | SANGER |
| SK-N-AS | - | Growth Inhibition Assay | - | IC50=43.6019 μM | SANGER |
| SK-N-DZ | - | Growth Inhibition Assay | - | IC50=4.96142 μM | SANGER |
| SK-NEP-1 | - | Growth Inhibition Assay | - | IC50=1.14485 μM | SANGER |
| SK-N-FI | - | Growth Inhibition Assay | - | IC50=24.3302 μM | SANGER |
| SK-OV-3 | - | Growth Inhibition Assay | - | IC50=5.99816 μM | SANGER |
| SK-PN-DW | - | Growth Inhibition Assay | - | IC50=27.6012 μM | SANGER |
| SN12C | - | Growth Inhibition Assay | - | IC50=124.176 μM | SANGER |
| SNB75 | - | Growth Inhibition Assay | - | IC50=6.60143 μM | SANGER |
| SNU-387 | - | Growth Inhibition Assay | - | IC50=1.88406 μM | SANGER |
| SNU-423 | - | Growth Inhibition Assay | - | IC50=2.89242 μM | SANGER |
| SNU-449 | - | Growth Inhibition Assay | - | IC50=27.0803 μM | SANGER |
| SNU-C2B | - | Growth Inhibition Assay | - | IC50=28.2964 μM | SANGER |
| SUNE-1 | 10 μM | Growth Inhibition Assay | 96 h | IC50=0.52 μM | 25336925 |
| SW1088 | - | Growth Inhibition Assay | - | IC50=1.94606 μM | SANGER |
| SW1116 | - | Growth Inhibition Assay | - | IC50=207.077 μM | SANGER |
| SW1417 | - | Growth Inhibition Assay | - | IC50=38.0552 μM | SANGER |
| SW1463 | - | Growth Inhibition Assay | - | IC50=7.11168 μM | SANGER |
| SW1573 | - | Growth Inhibition Assay | - | IC50=47.3736 μM | SANGER |
| SW1710 | - | Growth Inhibition Assay | - | IC50=3.46678 μM | SANGER |
| SW1736 | 100 μM | Growth Inhibition Assay | 5 d | IC50=47.56 μM | 21289267 |
| SW1783 | - | Growth Inhibition Assay | - | IC50=17.128 μM | SANGER |
| SW1990 | - | Growth Inhibition Assay | - | IC50=120.951 μM | SANGER |
| SW48 | - | Growth Inhibition Assay | - | IC50=36.2474 μM | SANGER |
| SW620 | - | Growth Inhibition Assay | - | IC50=66.2039 μM | SANGER |
| SW626 | - | Growth Inhibition Assay | - | IC50=33.1776 μM | SANGER |
| SW684 | - | Growth Inhibition Assay | - | IC50=98.6654 μM | SANGER |
| SW756 | - | Growth Inhibition Assay | - | IC50=11.5294 μM | SANGER |
| SW780 | - | Growth Inhibition Assay | - | IC50=14.5025 μM | SANGER |
| SW872 | - | Growth Inhibition Assay | - | IC50=5.59428 μM | SANGER |
| SW948 | - | Growth Inhibition Assay | - | IC50=27.1344 μM | SANGER |
| SW954 | - | Growth Inhibition Assay | - | IC50=11.4668 μM | SANGER |
| SW962 | - | Growth Inhibition Assay | - | IC50=26.5021 μM | SANGER |
| SW982 | - | Growth Inhibition Assay | - | IC50=207.948 μM | SANGER |
| T-24 | - | Growth Inhibition Assay | - | IC50=2.47881 μM | SANGER |
| T47D | - | Growth Inhibition Assay | - | IC50=0.2825 μM | SANGER |
| T84 | - | Growth Inhibition Assay | - | IC50=374.712 μM | SANGER |
| T98G | 0.5 μM | Apoptosis Assay | 60 h | Augments apoptogenic effects of gefitinib | 22057914 |
| T98G | - | Growth Inhibition Assay | - | IC50=8.18067 μM | SANGER |
| TAD2 | 1000 μM | Growth Inhibition Assay | 5 d | IC50>1000 μM | 21289267 |
| TCCSUP | - | Growth Inhibition Assay | - | IC50=59.5279 μM | SANGER |
| TE-1 | - | Growth Inhibition Assay | - | IC50=25.3563 μM | SANGER |
| TE-10 | - | Growth Inhibition Assay | - | IC50=91.5611 μM | SANGER |
| TE-11 | - | Growth Inhibition Assay | - | IC50=45.4842 μM | SANGER |
| TE-12 | - | Growth Inhibition Assay | - | IC50=6.83817 μM | SANGER |
| TE-5 | - | Growth Inhibition Assay | - | IC50=7.79334 μM | SANGER |
| TE-6 | - | Growth Inhibition Assay | - | IC50=6.93038 μM | SANGER |
| TE-8 | - | Growth Inhibition Assay | - | IC50=19.3024 μM | SANGER |
| TE-9 | - | Growth Inhibition Assay | - | IC50=363.589 μM | SANGER |
| TGBC11TKB | - | Growth Inhibition Assay | - | IC50=278.178 μM | SANGER |
| TGBC1TKB | - | Growth Inhibition Assay | - | IC50=12.9115 μM | SANGER |
| TGBC24TKB | - | Growth Inhibition Assay | - | IC50=36.67 μM | SANGER |
| TGW | - | Growth Inhibition Assay | - | IC50=4.02305 μM | SANGER |
| TI-73 | - | Growth Inhibition Assay | - | IC50=4.80609 μM | SANGER |
| TK10 | - | Growth Inhibition Assay | - | IC50=11.5271 μM | SANGER |
| TPC1 cells harbored RET/PTC1 rearrangement | 3 μM | Growth Inhibition Assay | 5 d | IC50=0.59 μM | 21289267 |
| TYK-nu | - | Growth Inhibition Assay | - | IC50=4.09534 μM | SANGER |
| U-118-MG | - | Growth Inhibition Assay | - | IC50=48.3702 μM | SANGER |
| U251 | - | Growth Inhibition Assay | - | IC50=9.65544 μM | SANGER |
| U-266 | - | Growth Inhibition Assay | - | IC50=75.4516 μM | SANGER |
| U-2-OS | - | Growth Inhibition Assay | - | IC50=25.6888 μM | SANGER |
| U-87-MG | - | Growth Inhibition Assay | - | IC50=133.604 μM | SANGER |
| UACC-257 | - | Growth Inhibition Assay | - | IC50=17.5512 μM | SANGER |
| UACC-62 | - | Growth Inhibition Assay | - | IC50=55.1046 μM | SANGER |
| UMC-11 | - | Growth Inhibition Assay | - | IC50=41.263 μM | SANGER |
| VA-ES-BJ | - | Growth Inhibition Assay | - | IC50=0.73025 μM | SANGER |
| VM-CUB-1 | - | Growth Inhibition Assay | - | IC50=2.39083 μM | SANGER |
| VMRC-RCZ | - | Growth Inhibition Assay | - | IC50=6.08773 μM | SANGER |
| WM-115 | - | Growth Inhibition Assay | - | IC50=13.6483 μM | SANGER |
| WRO | 1000 μM | Growth Inhibition Assay | 5 d | IC50>1000 μM | 21289267 |
| YAPC | - | Growth Inhibition Assay | - | IC50=28.2564 μM | SANGER |
| YH-13 | - | Growth Inhibition Assay | - | IC50=2.46153 μM | SANGER |
| YKG-1 | - | Growth Inhibition Assay | - | IC50=10.2006 μM | SANGER |
| ZR-75-30 | - | Growth Inhibition Assay | - | IC50=30.2383 μM | SANGER |
| 靶点 | Description | IC50 |
|---|---|---|
| Akt1 | IC50:8nM | |
| Akt2 | IC50:12nM | |
| Akt3 | IC50:65nM |
