CAS No.: 231957-54-3
MIV-150 Catalog No. CSN20547
Synonyms: PC 815
MIV-150 is a tight-binding, allosteric inhibitor of reverse transcriptase that is active against HIV-1 and HIV-2 (both EC50s = 1 nM in vitro).
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT02033109 HIV Phase 1 Completed - United States, Alabama ... more >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35294 Collapse << NCT03408899 HIV Infections Phase 1 Recruiting May 2019 United States, Alabama ... more >> Alabama CRS Recruiting Birmingham, Alabama, United States, 35294 Contact: Pam Cunningham, R.N., B.S.N., M.P.H. 205-975-2841 pamelacunningham@uabmc.edu United States, Pennsylvania University of Pittsburgh CRS Recruiting Pittsburgh, Pennsylvania, United States, 15213 Contact: Patricia Peters, R.Ph. 412-383-1434 pep1@pitt.edu Collapse << - 参考文献
- [1] Singer R, Mawson P, et al. An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques. Sci Transl Med. 2012 Sep 5;4(150):150ra123.
- [2] Geitmann M, Danielson UH. Additional level of information about complex interaction between non-nucleoside inhibitor and HIV-1 reverse transcriptase using biosensor-based thermodynamic analysis. Bioorg Med Chem. 2007 Dec 1;15(23):7344-54.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 231957-54-3 | 储存条件 |
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| 分子式 | C19H17FN4O3 | 运输 | 蓝冰 | |
| 分子量 | 368.36 | 别名 | PC 815 |
