|4,6-二吗啉-N-(4-硝基苯基)-1,3,5-三嗪-2-胺|CsnPharm

CAS No.: 326914-06-1

MHY1485/4,6-二(4-吗啉基)-N-(4-硝基苯基)-1,3,5-三嗪-2-胺 Catalog No. CSN16980

Synonyms: MHY1485

MHY1485 is a mTOR activator and inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Autophagy is a complicated process that consists of autophagosome biogenesis, maturation, and fusion with lysosomes, which can be induced by mtor inhibitor such as rapamycin. MHY1485 can activate mtor and suppress the basal autophagic flux in cells under starvation. It was shown that the LC3II/LC3I ratio and LC3II-positive vacuoles can be increased by simply treatment of MHY1485 2uM. However, compared with the group only with 10 nM bafilomycin A1 or 100uM chloroquine, treatment of MHY1485 2uM can decrease the LC3II protein level in Ac2F cells under starvation. These indicated that MHY1485 can suppress autophagic flux induced by starvation. Also the increase of both p-mTOR-Ser2448/mTOR ratio and the p4E-BP1-Thr37/46/4E-BP1 can be detected after treating cells with 2uM MHY1485, which indicated the activation of mTOR by MHY1485 ^[1]
作用机制MHY1485 showed a high docking score with the ATP domain of mTOR.
动物研究
剂量
Mice: 3 μg/kg^[2] (i.p.), 10 mg/kg^[3] (i.p.)

给药途径
i.p.

动物研究
剂量	Mice: 3 μg/kg^[2] (i.p.), 10 mg/kg^[3] (i.p.)
给药途径	i.p.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5814 mL
- 12.9068 mL
- 25.8136 mL
- 5 mM
- 0.5163 mL
- 2.5814 mL
- 5.1627 mL
- 10 mM
- 0.2581 mL
- 1.2907 mL
- 2.5814 mL

技术信息

CAS号

326914-06-1

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H21N7O4

运输

蓝冰

分子量

387.39

别名

MHY1485

溶解度

DMSO	4.0 mg/mL (10.3 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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MHY1485/4,6-二(4-吗啉基)-N-(4-硝基苯基)-1,3,5-三嗪-2-胺 Catalog No. CSN16980

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