|1-甲基-1,2,5,6-四氢吡啶-3-羧酸甲酯氢溴酸盐|CsnPharm

CAS No.: 300-08-3

氢溴酸槟榔碱 Catalog No. CSN10331

Synonyms: 氢溴酸槟榔碱;槟榔碱

Arecoline hydrobromide is a mAchR receptor agonist with EC50 values of 7, 95, 11, 410, and 69 nM for M1, M2, M3, M4, and M5, respectively, a nicotinic acid-based alkaloid found in the areca nut.

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400-920-2911

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技术信息

生物活性

描述Arecoline hydrobromide is a nicotinic acids-based alkaloid and a muscarinic acetylcholine receptor agonist. The LD50 of subcutaneous injection value is 100 mg/kg in mouse. In vivo research suggests that Arecoline hydrobromide has specific effects on either the circulating blood cells or their production and long-term administration of high doses of Ah is likely to be toxic^[3]. Arecoline treatment for 10 days at a dose of 10 mg/kg markedly facilitated β-cell regeneration and reversed testicular and sex accessory dysfunctions by increasing the levels of serum insulin and gonadotropins in type 1 diabetic rats^[4].
参考文献

[1] Saha I, Das J, et al. A protective role of arecoline hydrobromide in experimentally induced male diabetic rats. Biomed Res Int. 2015;2015:136738.
[2] Trejos A, Szyfres B, Marchevsky N. Comparative value of arecoline hydrobromide and bunamidine hydrochloride for the treatment of Echinococcus granulosus in dogs. Res Vet Sci. 1975 Sep;19(2):212-3.
[3] Wei X, Zhang J, Niu J, Zhou X, Li J, Li B. Evaluation of arecoline hydrobromide toxicity after a 14-day repeated oral administration in Wistar rats. PLoS One. 2015 Apr 16;10(4):e0120165. doi: 10.1371/journal.pone.0120165. PMID: 25880067; PMCID: PMC4399984.
[4] Saha I, Das J, Maiti B, Chatterji U. A protective role of arecoline hydrobromide in experimentally induced male diabetic rats. Biomed Res Int. 2015;2015:136738. doi: 10.1155/2015/136738. Epub 2015 Jan 28. PMID: 25695047; PMCID: PMC4324734.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.2354 mL
- 21.1769 mL
- 42.3538 mL
- 5 mM
- 0.8471 mL
- 4.2354 mL
- 8.4708 mL
- 10 mM
- 0.4235 mL
- 2.1177 mL
- 4.2354 mL

技术信息

CAS号

300-08-3

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C8H14BrNO2

运输

蓝冰

分子量

236.11

别名

氢溴酸槟榔碱;槟榔碱

溶解度

DMSO	44.0 mg/mL (186.4 mM)
Ethanol	10.0 mg/mL (42.4 mM)

动物实验配方

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氢溴酸槟榔碱 Catalog No. CSN10331

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