62-51-1|Acetyl-β-methylcholine chloride|CsnPharm

CAS No.: 62-51-1

Methacholine chloride/醋甲胆碱 Catalog No. CSN17103

Synonyms: Acetyl-β-methylcholine chloride;Provocholine;Acetyl-beta-methylcholine Chloride

Acetyl-β-methylcholine chloride is a quaternary ammonium parasympathomimetic agent targeting on mAchR.

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400-920-2911

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实验方案

技术信息

生物活性

描述Methacholine Chloride is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system. A lower methacholine concentration was required to elicit half of the maximal response (i.e., EC50) in females, whereas a greater cutaneous vasodilation was observed during a higher concentration of methacholine administration (100 mM) in males ^[3]. Methacholine chloride bronchoprovocation challenges are performed for the diagnosis and investigation of hyperreactive airways^[4].
参考文献

[1] Sagara H, Tanaka A, et al. [The Safety and efficacy of airway-hyperresponsiveness test for asthma using by SK-1211 (Methacholine Chloride)] . Arerugi. 2016 Feb;65(1):32-40.
[2] Birnbaum S, Barreiro TJ. Methacholine challenge testing: identifying its diagnostic role, testing, coding, and reimbursement. Chest. 2007 Jun;131(6):1932-5.
[3] Fujii N, Halili L, Singh MS, Meade RD, Kenny GP. Intradermal administration of ATP augments methacholine-induced cutaneous vasodilation but not sweating in young males and females. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15;309(8):R912-9.
[4] Watson BL, Cormier RA, Harbeck RJ. Effect of pH on the stability of methacholine chloride in solution. Respir Med. 1998 Mar;92(3):588-92.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.1101 mL
- 25.5506 mL
- 51.1012 mL
- 5 mM
- 1.0220 mL
- 5.1101 mL
- 10.2202 mL
- 10 mM
- 0.5110 mL
- 2.5551 mL
- 5.1101 mL

技术信息

CAS号

62-51-1

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C8H18ClNO2

运输

蓝冰

分子量

195.69

别名

Acetyl-β-methylcholine chloride;Provocholine;Acetyl-beta-methylcholine Chloride;Methacholine;Acetyl-β-methylcholine (chloride);Methacholine Chloride;Mecholyl chloride;Amechol;Methapharma Brand of Methacholine Chloride;Provokit;Roche Brand of Methacholine Chloride;醋甲胆碱

溶解度

DMSO	200.0 mg/mL (1022.0 mM) warming
Water	200.0 mg/mL (1022.0 mM)

动物实验配方

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