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CAS No.: 59-47-2

Mephenesin/甲酚甘油醚 Catalog No. CSN11379

Synonyms: Decontractyl;Cresoxydiol;Memphenesin

Mephenesin is a centrally acting muscle relaxant which may work as an NMDA receptor antagonist.

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技术信息

生物活性

描述Mephenesin is an NMDA receptor antagonist, is a centrally acting muscle relaxant^[3]. Mephenesin also inhibited MSR (mono-synaptic reflex) and PSR (poly-synaptic reflex), though the effects were short in duration. Both CPC (chlorphenesin carbamate) and mephenesin inhibit the firing of motoneurons by stabilizing the neuronal membrane, while mephenesin additionally suppresses the dorsal root reflex and the excitability of the primary afferent terminal^[4]. The marked dependence on structure of the anticonvulsant activity of the mephenesin isomers can be interpreted as evidence that pressure acts not by some general perturbation of the membranes of excitable cells but rather via some specific interaction^[5]. The spontaneous firings of the VB nociceptive neurons were depressed by both CPC (50 mg/kg, i.v.) and mephenesin (50 mg/kg, i.v.). However, mephenesin (50 mg/kg, i.v.) but not CPC (50 mg/kg, i.v.) also depressed the spontaneous firings of the mesencephalic reticular formation (RF), in these adjuvant arthritic rats^[6]. Mephenesin (40 and 80 mg/kg, i.v.) depressed the amplitude of the fEMG (flexor EMG: fEMG) dose-dependently^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.4880 mL
- 27.4399 mL
- 54.8798 mL
- 5 mM
- 1.0976 mL
- 5.4880 mL
- 10.9760 mL
- 10 mM
- 0.5488 mL
- 2.7440 mL
- 5.4880 mL

技术信息

CAS号

59-47-2

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H14O3

运输

蓝冰

分子量

182.22

别名

Decontractyl;Cresoxydiol;Memphenesin;Mephedan;Prolaxin;Cresoxypropanediol;NSC 25234;甲酚甘油醚

溶解度

DMSO	98.0 mg/mL (537.8 mM)

动物实验配方

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