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CAS No.: 10458-14-7

Menthone/薄荷酮 Catalog No. CSN11377

Synonyms: p-Menthan-3-one;NSC 113134;NSC 9280

Menthone, a natural product isolated and purified from the herbs of Mentha canadensis L., enhances the skin permeability by disordering the ordered organization of SC lipids and extracts part of SC lipids, while pulegone appears to promote drug transport across the skin only by extracting part of SC lipids.

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生物活性

描述Menthone, a natural product isolated and purified from the herbs of Mentha canadensis L., enhances the skin permeability by disordering the ordered organization of SC (stratum corneum) lipids and extracts part of SC lipids, while pulegone appears to promote drug transport across the skin only by extracting part of SC lipids^[3]. Vit C and menthone at higher dose have a good compensatory effect with significant reduction in DNA damages in sperm cells by reversing the adverse effect of ACV (Acyclovir) on the reproductive system in male rat^[4]. Menthone, a component of peppermint oil, was given p.o. to groups of 10 male and 10 female rats at dose levels of 0, 200, 400 and 800 mg/kg b.w./day, respectively, for 28 days. After 19 days the dose was reduced to 400 mg/kg b.w. in the female group receiving the highest dose. Analyses of plasma showed a dose-dependent decrease in creatinine content and a dose-dependent increase in alkaline phosphatase activity and bilirubin. The relative weights of liver and spleen were increased. Cyst-like spaces were seen histopathologically in the white matter of the cerebellum of the two highest dose groups^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02106403	Skin Care	Not Applicable	Completed	-	China, Guangdong ... more >> Guangzhou Landproof Testing Technology Co., LTD Guangzhou, Guangdong, China, 510635 Collapse <<
NCT03475836	Cognitive Change ... more >> Affect Collapse <<	Not Applicable	Completed	-	-
NCT02106403	-	-	Completed	-	-

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.4830 mL
- 32.4149 mL
- 64.8298 mL
- 5 mM
- 1.2966 mL
- 6.4830 mL
- 12.9660 mL
- 10 mM
- 0.6483 mL
- 3.2415 mL
- 6.4830 mL

技术信息

CAS号	10458-14-7	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C10H18O	运输	蓝冰
分子量	154.25	别名	p-Menthan-3-one;NSC 113134;NSC 9280;2-Isopropyl-5-Methylcyclohexanone;薄荷酮;孟酮

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