|3-(2,4-二氯-5-甲氧基苯基)-2-巯基喹唑啉-4(3H)-酮|CsnPharm

CAS No.: 338967-87-6

Mdivi-1 Catalog No. CSN16979

Synonyms: Mitochondrial division inhibitor 1

Mdivi-1 selectively inhibits mitochondrial division DRP1 and mitochondrial division Dynamin I (Dnm1), the IC50 is about 1-10 µM.

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400-920-2911

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 DRP1

IC50:1-10μM Dynamin I

IC50:1-10μM
描述Mdivi-1, derivative of quinazolinone, is a selective inhibitor of mitochondrial division by targeting Dnm1 (dynamin-1) and DRP (dynamin-related protein). In mammalian cells (COS cell), mdivi-1 inhibits mitochondrial division with IC50 of 50 μM by specially inhibiting DRP1 activity, and in Hela cell, mdivi-1 impedes apoptosis early in the intrinsic pathway by attenuating Bak/Bax dependent MOMP (mitochondrial outer membrane permeabilization)^[3]. It has been shown to reduce seizure activity and increase survival of KA-reduced mice intravenously injected of 20 mg/kg mdivi-1 by protecting mitochondrial morphology and attenuating cell death in the hippocampus^[4]. In the study of ischemia reperfusion injury, mdivi-1 can protect against ischemia reperfusion injury of spinal cord neurons and mitochondrial dysfunction in vivo through activating BK channels dependently in SD rat which were treated with intravenous bolus of 1 mg/kg^[5]. The function of mdivi-1 is also reflected in the protection of ischemic retina. Research has shown that mdivi-1 can reverse cell apoptosis caused by transient retinal ischemia and significantly increase the number and survival of retinal ganglia cells by approximately 54% in 3-month-old C57BL/6 mice (intraperitoneal injection, 50 mg/kg). In addition, mdivi-1 treatment did not affect the increase of Drp1 protein expression, but obviously down-regulate the expression of GFAP^[6]. Multiple roles of mdivi-1, such as reduces animal blood pressure, alleviate traumatic brain injury induced brain damage^[7], and protect against doxorubicin-induced cardiotoxicity, have confirmed by relevant experiments^[8]. In general, mdivi-1 provides a new treatment for stroke, myocardial infarction and neurodegenerative diseases.
动物研究
剂量
Rat: 20 mg/kg^[3] (i.p.), 1.25 mg/kg^[4] Mice: 20 mg/kg^[5] (i.p.), 50 mg/kg^[1] (i.p.), 1.2 mg/kg^[6] (i.v.)

给药途径
i.p., i.v.

动物研究
剂量	Rat: 20 mg/kg^[3] (i.p.), 1.25 mg/kg^[4] Mice: 20 mg/kg^[5] (i.p.), 50 mg/kg^[1] (i.p.), 1.2 mg/kg^[6] (i.v.)
给药途径	i.p., i.v.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8311 mL
- 14.1554 mL
- 28.3107 mL
- 5 mM
- 0.5662 mL
- 2.8311 mL
- 5.6621 mL
- 10 mM
- 0.2831 mL
- 1.4155 mL
- 2.8311 mL

技术信息

CAS号

338967-87-6

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H10Cl2N2O2S

运输

蓝冰

分子量

353.22

别名

Mitochondrial division inhibitor 1

溶解度

DMSO	300.0 mg/mL (849.3 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+40% PEG300+water	3 mg/mL	clear
PO	0.5% CMC-Na	30 mg/mL	suspension

大规格询价

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靶点	Description	IC50
DRP1		IC50:1-10μM
Dynamin I		IC50:1-10μM

Mdivi-1 Catalog No. CSN16979

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