|2-((2R,3S,4S,5R,6S)-6-((R)-1-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,5R,5'R)-3'-(((2R,4S,5S,6S)-4,5-二甲氧基-6-甲基四氢-2H-吡喃-2-基)氧基)-5'-((2S,3S,5R,6S)-6-羟基-3,5,6-三甲基四氢-2H-吡喃-2-基)-2-甲基八氢-[2,2'-二呋喃]-5-基)-9-羟基- 2,8-二甲基-1,6-二氧杂螺[4.5]癸七-7-基)乙基)-2-羟基-4,5-二甲氧基-3-甲基四氢-2H-吡喃-2-基)乙酸铵|CsnPharm

CAS No.: 84878-61-5

Maduramicin ammonium Catalog No. CSN21720

Synonyms: Maduramycin ammonium;Maduramicin (ammonium salt);Antibiotic X-14868A

Maduramicin Ammonium Salt is an antiprotozoal agent, is a natural product isolated from the actinomycete Actinomadura rubra.

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技术信息

生物活性

描述Maduramicin Ammonium Salt is isolated from the actinomycete Actinomadura rubra. Maduramicin ammonium (Maduramycin ammonium) is an anticoccidial agent for the the treatment of Eimeria spp., E. adenoeides, E. gallopavonis, and E. dispersa infection. Maduramicin ammonium given at 5-7 ppm prevented mortality, significantly reduced droppings scores and oocyst passage, and improved weight gain to near that of the unmedicated uninfected controls. Mortality from coccidiosis averaged 11.9% in unmedicated controls, compared with 0.6% with 4 ppm of maduramicin or no mortality with 5-7 ppm. Average weight gain and feed conversion at 10 weeks were significantly improved over unmedicated infected controls when maduramicin ammonium was given at 5-7 ppm^[1]. Maduramicin causes morphological changes and a decrease in the viability of chicken myocardial cells. Maduramicin is cytotoxic to primary chicken myocardial cells via caspase dependent and independent apoptotic pathways^[2].
参考文献

[1] McDougald LR, Fuller AL, Mathis GF, Wang GT. Efficacy of maduramicin ammonium against coccidiosis in turkeys under laboratory and floor-pen conditions. Avian Dis. 1990 Jul-Sep;34(3):634-8
[2] Gao X, Zheng Y, Peng L, Ruan X, Ji H, Qiu Y, Liu X, Teng P, Guo D, Jiang S. Maduramicin induces apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways. Toxicol In Vitro. 2018 Aug;50:190-200

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.0705 mL
- 5.3524 mL
- 10.7048 mL
- 5 mM
- 0.2141 mL
- 1.0705 mL
- 2.1410 mL
- 10 mM
- 0.1070 mL
- 0.5352 mL
- 1.0705 mL

技术信息

CAS号

84878-61-5

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C47H83NO17

运输

蓝冰

分子量

934.16

别名

Maduramycin ammonium;Maduramicin (ammonium salt);Antibiotic X-14868A;CL 259,971;Maduramycin;Prinicin;Maduramicin;马杜拉霉素铵盐

溶解度

DMSO	25.0 mg/mL (26.8 mM)
Water	insoluble

动物实验配方

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