生物活性

• 描述MSC2363318A, also known as M2698, is an orally available inhibitor of the serine/threonine protein kinases ribosomal protein S6 Kinase (p70S6K) and Akt (protein kinase B), with potential antineoplastic activity. Upon administration, p70S6K/Akt inhibitor MSC2363318A binds to and inhibits the activity of p70S6K and Akt. This prevents the activation of the PI3K/Akt/p70S6K signaling pathway and inhibits tumor cell proliferation in cancer cells that have an overactivated PI3K/Akt/p70S6K signaling pathway. Constitutive activation and dysregulated signaling of the PI3K/Akt/p70S6K pathway are frequently associated with tumorigenesis of many tumor types; targeting multiple kinases in this pathway is more efficacious than targeting a single kinase.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01971515	Solid Tumor	Phase 1	Completed	-	United States, Alabama ... more >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35294 United States, California Cedars Sinai Medical Center Los Angeles, California, United States, 90048 University of California at San Diego, Moores Cancer Center San Diego, California, United States, 92093 United States, Florida Sylvester Comprehensive Cancer Center Miami, Florida, United States, 33136 United States, Louisiana Metairie Oncology Metairie, Louisiana, United States, 70006 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 United States, Michigan Karmanos Cancer Institute Detroit, Michigan, United States, 48201 Henry Ford Hospital Detroit, Michigan, United States, 48202 United States, Missouri Washington University School of Medicine Saint Louis, Missouri, United States, 63110 United States, New York Mount Sinai New York, New York, United States, 10029 United States, South Carolina Medical University of South Carolina Charleston, South Carolina, United States, 29425 United States, Texas Mary Crowley Cancer Research Center Dallas, Texas, United States, 75251 MD Anderson Cancer Center Houston, Texas, United States, 77030 University of Texas Health Science Center at San Antonio San Antonio, Texas, United States, 78229 United States, Vermont Fletcher Allen Health Care, Inc. Burlington, Vermont, United States, 05401 Collapse <<