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CAS No.: 946518-60-1

LY2409881 3HCl Catalog No. CSN16201

Synonyms: LY2409881

LY2409881 3HCl is a selective inhibitor of IKK2 with IC50 of 30 nM and IC50 for IKK1 and other common kinases is at least one log higher.

规格	价格	促销价格	库存	数量

400-920-2911

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 IKK2

IC50:30nM
描述The NF-kB pathway plays a key role in multiple cellular processes, including immune signaling, inflammation, development, proliferation and survival. The activation of the upstream molecule, IKKα or β (IkB kinase), is required for NF-kB pathway and regulates NF-kB pathway via phosphorylation by specific IKK kinases and by autophosphorylation. LY2409881 Trihydrochloride is the trihydrochloride form of LY2409881. LY2409881 is a selective IKK2 inhibitor with IC50 value of 30nM by in vitro kinase assay, with IC50s at least one log higher for IKK1 and other common kinases. Treatment with 10μM LY2409881 led to suppression of TNFα-induced phosphorylation of IκB in DLBCL cell line within 60 minutes. The block of constitute activation of NF-κB, shown as the exclusion of p50 from nuclear, can be observed in SUDHL2 cells exposure to 10μM LY2409881 for 4 hours. LY2409881 led to a concentration-dependent increase of apoptosis at concentration of 10 and 20μM in the DLBCL cell line SUDHL2 cells after 24 hours of exposure, inhibited survival and proliferation of the DLBLC cell line LY10 in both time (24-72h)- and dose-dependent manner and caused concentration-dependent apoptosis and cell death in MT2 cells after 48 hours of exposure at concentration ranging in 1-8μM. Intraperitoneal injections with LY2409881 twice weekly at dose of 50, 100, and 200 mg/kg all slowed the rate of tumor growth in SCID-beige mice implanted with LY10 cell-derived tumors.
动物研究
剂量
Mice: 50 mg/kg - 200 mg/kg^[2] (i.p.)

给药途径
i.p.)

动物研究
剂量	Mice: 50 mg/kg - 200 mg/kg^[2] (i.p.)
给药途径	i.p.)

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.6823 mL
- 8.4115 mL
- 16.8229 mL
- 5 mM
- 0.3365 mL
- 1.6823 mL
- 3.3646 mL
- 10 mM
- 0.1682 mL
- 0.8411 mL
- 1.6823 mL

技术信息

CAS号

946518-60-1

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H32Cl4N6OS

运输

蓝冰

分子量

594.43

别名

LY2409881

溶解度

DMSO	20.0 mg/mL (33.6 mM) warming
Water	Insoluble
Ethanol	Insoluble

动物实验配方

2% DMSO+30% PEG 300+5% Tween 80+water

5 mg/mL

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LY2409881 3HCl Catalog No. CSN16201

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