CAS No.: 892128-60-8
LY2334737 Catalog No. CSN18532
Synonyms: gemcitabine prodrug
LY2334737 is an orally available prodrug of gemcitabine which is a nucleoside analog used as chemotherapy.
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- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00981058 Non Small Cell Lung Cancer Phase 3 Active, not recruiting December 31, 2018 - NCT00981058 - - Active, not recruiting - - NCT01648764 Malignant Solid Tumor ... more >> Solid Tumor Metastatic Tumor Collapse << Phase 1 Completed - United States, Pennsylvania ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Philadelphia, Pennsylvania, United States, 19111 France For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Clichy, France, 92118 Germany For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Berlin, Germany, 13353 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Nürnberg, Germany, 90419 Collapse << - 参考文献
- [1] Pratt SE, Durland-Busbice S, et al. Human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (LY2334737) and confers prodrug sensitivity to cancer cells. Clin Cancer Res. 2013 Mar 1;19(5):1159-68.
- [2] Koolen SL, Witteveen PO, et al. Phase I study of Oral gemcitabine prodrug (LY2334737) alone and in combination with erlotinib in patients with advanced solid tumors. Clin Cancer Res. 2011 Sep 15;17(18):6071-82.
实验方案
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技术信息
| CAS号 | 892128-60-8 | 储存条件 |
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| 分子式 | C17H25F2N3O5 | 运输 | 蓝冰 | |
| 分子量 | 389.39 | 别名 | gemcitabine prodrug |
