生物活性

• 描述Lumefantrine is an antimalarial drug, used in combination with Artemether. artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) as the first- and second-line anti-malarial drugs, respectively^[3]. The fixed dose combination of artemether-lumefantrine (AL) is the most widely used treatment for uncomplicated Plasmodium falciparum malaria. Lumefantrine exposure decreased with increasing pre-treatment parasitaemia, and the dose limitation on absorption of lumefantrine was substantial. Simulations using the lumefantrine pharmacokinetic model suggest that, in young children and pregnant women beyond the first trimester, lengthening the dose regimen (twice daily for 5 days) and, to a lesser extent, intensifying the frequency of dosing (3 times daily for 3 days) would be more efficacious than using higher individual doses in the current standard treatment regimen (twice daily for 3 days) ^[4]. Artemether-lumefantrine is often coadministered with efavirenz-based antiretroviral therapy for malaria treatment in HIV-infected women during pregnancy. Overall, pregnancy tempered the extent of efavirenz-lumefantrine interactions, resulting in increased lumefantrine exposure^[5].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00164710	Malaria, Falciparum	Phase 4	Completed	-	Malawi ... more >> Kawale Health Center Lilongwe, Lilongwe District, Malawi Machinga District Hospital Liwonde, Machinga District, Malawi Matiki Health Center Dwangwa, Nkhotakota District, Malawi Collapse <<
  NCT00541385	Malaria	Phase 3	Completed	-	Burkina Faso ... more >> Centre National de Recherche et de Formation sur le Paludisme Ouagadougou, Burkina Faso Congo Ecole de Santé Publique, Faculté de Médecine, Université de Kinshasa Kinshasa, DRC, Congo Côte D'Ivoire Unité de Paludologie de l'Institut Pasteur d'Abidjan Abdijan, Côte D'Ivoire Gabon Medical Research Unit, Albert Schweitzer Hospital Lambaréné, Gabon Kenya Siaya District Hospital, Medical Superintendent's office Siaya Town, Kenya Mali Malaria Research and Training Center, Faculté de Médecine, de Pharmacie et d'Ondonto-stomatologie Bamako, Mali Mozambique Instituto Nacional de Saude, Ministero de Saude Maputo, Mozambique Philippines Puerto Princesa General Hospital Puerto Princesa, Philippines Collapse <<
  NCT00484900	Plasmodium Falciparum Malaria	Phase 3	Completed	-	Cameroon ... more >> Cameroon Baptist Convention Clinic of Biyem-Assi Yaounde, Cameroon Mali Health centres of Samako, Kolle and Bancoumane Bamako, Mali Rwanda Health centres Rwamagana and Muhima Kigali, Rwanda Sudan Alhara Alola Health centre New Halfa, Sudan Collapse <<

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• 参考文献

• [1] Ndounga M, Pembe Issamou Mayengue, et al. Artesunate-amodiaquine versus artemether-lumefantrine for the treatment of acute uncomplicated malaria in Congolese children under 10 years old living in a suburban area: a randomized study. Malar J. 2015 Oct 29;14(1):423.

  [2] Mutabingwa TK, Anthony D, et al. Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm randomised effectiveness trial. Lancet. 2005 Apr 23-29;365(9469):1474-80.

  [3] Ndounga M, Pembe Issamou Mayengue, Casimiro PN, et al. Artesunate-amodiaquine versus artemether-lumefantrine for the treatment of acute uncomplicated malaria in Congolese children under 10 years old living in a suburban area: a randomized study. Malar J. 2015;14:423. Published 2015 Oct 29

  [4] Kloprogge F, Workman L, Borrmann S, et al. Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis. PLoS Med. 2018;15(6):e1002579. Published 2018 Jun 12

  [5] Adegbola A, Abutaima R, Olagunju A, et al. Effect of Pregnancy on the Pharmacokinetic Interaction between Efavirenz and Lumefantrine in HIV-Malaria Coinfection. Antimicrob Agents Chemother. 2018;62(10):e01252-18. Published 2018 Sep 24

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