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CAS No.: 50264-69-2

Lonidamine/氯尼达明 Catalog No. CSN17292

Synonyms: AF-1890;Diclondazolic Acid;DICA

Lonidamine is an inactivator of hexokinase.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Lonidamine is a selective inhibitor that inhibits aerobic glycolysis in murine tumor cells. Lonidamine at a concentration of 0.32mM reduced the respiration of germ cells and submaxillary gland cells by 58%. Treatment of Serotoli's cells and hepatocytes with lonidamine led to 16% and 6% inhibition of oxygen consumption, respectively. Lonidamine at the same concentration inhibited oxygen consumption of Ehrlich ascites tumor cells and sarcoma 180 cells by 58 and 63%, respectively, but enhanced aerobic glycolysis in normal cells, such as germ cells (57%) and submaxillary gland cells (35%). Lonidamine at a concentration of 20mM reduced the amount of glucose 6-phosphate formed by the mitochondria of Ehrlich ascites tumor cells by >50%.^[2] Lonidamine inhibited glioma cell proliferation with an IC50 value of 200μM. Treatment of SNb-19 cells with 100 or 200μM lonidamine resulted in a slight decrease in the S-phase component of the cell cycle (3% and 9%, respectively). The administration of nude mice with lonidamine (160 mg/kg body weight/day) and diazepam (1 mg/kg body weight/day) via intraperitoneal injection for 10 days inhibited the growth of TG-8-OZ glioma xenograft (78% inhibition) 7 days after the treatment.^[1]
作用机制Lonidamine is a derivative of indazole-3-carboxylic acid that affects energy metabolism in tumor cells by inhibiting mitochondria-bound hexokinase and the electron transport chain.^[1]
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00237536	Benign Prostatic Hyperplasia	Phase 2	Terminated	-	-
NCT00435448	Benign Prostatic Hyperplasia ... more >> Enlarged Prostate Collapse <<	Phase 3	Terminated	-	-

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.1137 mL
- 15.5687 mL
- 31.1373 mL
- 5 mM
- 0.6227 mL
- 3.1137 mL
- 6.2275 mL
- 10 mM
- 0.3114 mL
- 1.5569 mL
- 3.1137 mL

技术信息

CAS号

50264-69-2

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H10Cl2N2O2

运输

蓝冰

分子量

321.16

别名

AF-1890;Diclondazolic Acid;DICA;Doridamina;氯尼达明

溶解度

DMSO	350.0 mg/mL (1089.8 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+40% PEG300+water	7 mg/mL	clear
PO	0.5% CMC-Na	42 mg/mL	suspension

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Lonidamine/氯尼达明 Catalog No. CSN17292

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