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CAS No.: 103129-82-4

Levamlodipine/左旋氨氯地平 Catalog No. CSN27383

Synonyms: (S)-Amlodipine;Levoamlodipine;S-Amlodipine

Levamlodipine ((S)-Amlodipine) is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina.

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生物活性

描述Levamlodipine is a calcium channel blocker drug. Levamlodipine (LEE) is a drug commonly used for antihypertensive treatment in clinical therapy^[2]. Combined use of levamlodipine and bisoprolol produced better protection against stroke^[3]. A single dose of levamlodipine (from 1 mg/kg), bisoprolol (from 0.125 mg/kg), and their combinations significantly decreased blood pressure. The levamlodipine-induced tachycardia and the bisoprolol-induced bradycardia were temporized by the combination of these two drugs. Levamlodipine and bisoprolol produce synergic effects on blood pressure reduction and organ protection in SHR(spontaneously hypertensive rats) ^[4].
参考文献

[1] Jain R, et al. Polyaniline-graphene oxide nanocomposite sensor for quantification of calcium channel blocker levamlodipine. Mater Sci Eng C Mater Biol Appl. 2016 Aug 1;65:205-14.
[2] Liu Z, Huang X, Jiang Z, Tuo X. Investigation of the binding properties between levamlodipine and HSA based on MCR-ALS and computer modeling. Spectrochim Acta A Mol Biomol Spectrosc. 2021 Jan 15;245:118929
[3] Gui H, Guo YF, Liu X, Zhang JM, Yang YL, Huang GZ, Liu JG. Effects of combination therapy with levamlodipine and bisoprolol on stroke in rats. CNS Neurosci Ther. 2013 Mar;19(3):178-82
[4] Yang YL, Yu LT, Wu ZT, Yu JG, Zhang JM, Chen QH, Bao YC, Liu JG. Synergic effects of levamlodipine and bisoprolol on blood pressure reduction and organ protection in spontaneously hypertensive rats. CNS Neurosci Ther. 2012 Jun;18(6):471-4

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4457 mL
- 12.2286 mL
- 24.4573 mL
- 5 mM
- 0.4891 mL
- 2.4457 mL
- 4.8915 mL
- 10 mM
- 0.2446 mL
- 1.2229 mL
- 2.4457 mL

技术信息

CAS号

103129-82-4

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H25ClN2O5

运输

蓝冰

分子量

408.88

别名

(S)-Amlodipine;Levoamlodipine;S-Amlodipine;左旋氨氯地平

溶解度

DMSO	79.0 mg/mL (193.2 mM)
Water	79.0 mg/mL (193.2 mM)
Ethanol	80.0 mg/mL (195.7 mM)

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