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CAS No.: 24697-74-3

Leonurine HCl/盐酸益母草碱 Catalog No. CSN12376

Synonyms: SCM-198;益母草碱;盐酸益母草碱

Leonurine is a pseudoalkaloid possessing anti-inflammatory properties and isolated from plants of family Lamiaceae.

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技术信息

生物活性

描述Leonurine is a chemically synthesized compound based on a bioactive alkaloid extracted from Herba leonuri.Administration of leonurine (60 mg/kg) for 4 weeks significantly alleviated depression-like behaviors of chronic mild stress mice and restored the levels of 5-hydroxytryptamine, noradrenaline, and dopamine in the hippocampus and prefrontal cortex of chronic mild stress mice, accompanied by amelioration of hippocampal neuronal damage^[3]. Moreover,leonurine significantly increased the expressions of ABCA1 and ABCG1(cholesterol transporters) at the mRNA and protein levels in a dose-dependent manner(0, 5, 10, 20, 40, 80 µM for 24 h)^[4].
参考文献

[1] Gao H, Yang X, et al. Synthesis and biological evaluation of the codrug of Leonurine and Aspirin as cardioprotective agents. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4650-4.
[2] Song X, Wang T, et al. Leonurine exerts anti-inflammatory effect by regulating inflammatory signaling pathways and cytokines in LPS-induced mouse mastitis. Inflammation. 2015 Feb;38(1):79-88.
[3] Jia M, Li C, Zheng Y, Ding X, Chen M, Ding J, Du R, Lu M, Hu G. Leonurine Exerts Antidepressant-Like Effects in the Chronic Mild Stress-Induced Depression Model in Mice by Inhibiting Neuroinflammation. Int J Neuropsychopharmacol. 2017 Nov 1;20(11):886-895. doi: 10.1093/ijnp/pyx062. PMID: 29016795; PMCID: PMC5737563.
[4] Jiang T, Ren K, Chen Q, Li H, Yao R, Hu H, Lv YC, Zhao GJ. Leonurine Prevents Atherosclerosis Via Promoting the Expression of ABCA1 and ABCG1 in a Pparγ/Lxrα Signaling Pathway-Dependent Manner. Cell Physiol Biochem. 2017;43(4):1703-1717. doi: 10.1159/000484031. Epub 2017 Oct 18. PMID: 29045950.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2120 mL
- 16.0599 mL
- 32.1199 mL
- 5 mM
- 0.6424 mL
- 3.2120 mL
- 6.4240 mL
- 10 mM
- 0.3212 mL
- 1.6060 mL
- 3.2120 mL

技术信息

CAS号

24697-74-3

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H21N3O5

运输

蓝冰

分子量

311.33

别名

SCM-198;益母草碱;盐酸益母草碱

溶解度

DMSO	330.0 mg/mL (1060.0 mM)
Water	insoluble

动物实验配方

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Leonurine HCl/盐酸益母草碱 Catalog No. CSN12376

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