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CAS No.: 190791-29-8

Lasofoxifene tartrate Catalog No. CSN16955

Synonyms: CP-336156 tartrate;CP-336156;Lasofoxifene (tartrate)

Lasofoxifene tartrate, a non-steroidal compound, is a modulator of estrogen receptor.

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400-920-2911

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技术信息

生物活性

描述Lasofoxifene Tartrate, a new potent, nonsteroidal SERM, binds with high affinity to human estrogen receptors and acts as a tissue selective estrogen antagonist or agonist. In preclinical models of postmenopausal osteoporosis, lasofoxifene inhibited bone turnover and prevented bone loss throughout the skeleton. In preclinical studies designed to evaluate the effects of lasofoxifene in breast cancer, lasofoxifene inhibited breast tumor formation in mice injected with human MCF-7 breast cancer cells and in rats bearing mammary carcinomas^[3]. Lasofoxifene Tartrate is a non-steroidal selective estrogen receptor modulator (SERM). LAS (Lasofoxifene Tartrate) and BZA (bazedoxifene) reduced the clinical severity of arthritis as well as the grade of histologic synovitis and erosions on cartilage and bone. The anti-osteoporotic drugs LAS and BZA were found to be potent inhibitors of joint inflammation and bone destruction in experimental arthritis^[4]. Compared with raloxifene, lasofoxifene gave greater decreases in BTMs(bone turnover markers), and greater increases in lumbar spine BMD (bone mineral density). Lasofoxifene also decreased the risk of breast cancer, major coronary heart disease events, and stroke, but-similar to raloxifene-there was an increased risk of venous thromboembolism^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7742 mL
- 8.8709 mL
- 17.7419 mL
- 5 mM
- 0.3548 mL
- 1.7742 mL
- 3.5484 mL
- 10 mM
- 0.1774 mL
- 0.8871 mL
- 1.7742 mL

技术信息

CAS号

190791-29-8

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C32H37NO8

运输

蓝冰

分子量

563.64

别名

CP-336156 tartrate;CP-336156;Lasofoxifene (tartrate);CP 336,156;Fablyn

溶解度

DMSO	99.0 mg/mL (175.6 mM)
Water	Insoluble
Ethanol	Insoluble

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