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CAS No.: 571170-77-9
Synonyms: MK-0524;Cardaptive;Tredaptive
Laropiprant is a potent, selective DP1 receptor antagonist with Ki value of 0.57 nM and exhibits > 1,000 fold selectivity over DP2 receptor (Ki=0.75 μM).
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT01071278 | - | - | Completed | - | - |
NCT00533676 | Flushing | Phase 2 | Completed | - | - |
NCT01450410 | Dyslipidemias | Phase 4 | Terminated(Study terminated (h... more >>alted prematurely) as recomended by the drug supplier and medical agencies) Collapse << | May 2013 | Spain ... more >> Unitat Funcional de Risc Vascular. Servei Medicina Interna. Hospital Universitari de Bellvitge. L'Hospitalet de Llobregat, Barcelona, Spain, 08907 Collapse << |
实验方案
技术信息
CAS号 | 571170-77-9 | 储存条件 |
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分子式 | C21H19ClFNO4S | 运输 | 蓝冰 | |||||
分子量 | 435.90 | 别名 | MK-0524;Cardaptive;Tredaptive | |||||
溶解度 |
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动物实验配方 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT01071278 | - | - | Completed | - | - |
NCT00533676 | Flushing | Phase 2 | Completed | - | - |
NCT01450410 | Dyslipidemias | Phase 4 | Terminated(Study terminated (h... more >>alted prematurely) as recomended by the drug supplier and medical agencies) Collapse << | May 2013 | Spain ... more >> Unitat Funcional de Risc Vascular. Servei Medicina Interna. Hospital Universitari de Bellvitge. L'Hospitalet de Llobregat, Barcelona, Spain, 08907 Collapse << |
NCT01118598 | Polycystic Ovary Syndrome | Phase 4 | Completed | - | United Kingdom ... more >> Hull & East Yorkshire Hospitals NHS Trust Hull, United Kingdom, HU3 2RW Collapse << |
NCT01071278 | - | - | Completed | - | - |
NCT01391377 | Peripheral Arterial Disease | Not Applicable | Terminated(Tredaptive has been... more >> suspended worldwide) Collapse << | December 2014 | Australia, Victoria ... more >> Baker IDI Heart and diabetes research institute Melbourne, Victoria, Australia, 3004 Collapse << |
NCT01071525 | Hypercholesterolemia | Phase 3 | Unknown | October 2010 | Israel ... more >> Rambam Health Care Campus Not yet recruiting Haifa, Israel, 31096 Contact: Shadi +972-523591876 s_hamoud@rambam.health.gov.il Contact: Tony Hayek, Prof +972-523782009 t_hayek@rambam.health.gov.il Sub-Investigator: Tony Hayek, Prof Collapse << |
NCT01054508 | Hypercholesterolemia | Phase 4 | Completed | - | United Kingdom ... more >> Manchester Royal Infirmary Manchester, United Kingdom, M13 9WL Collapse << |
NCT02153879 | Type 2 Diabetes Mellitus ... more >> Dyslipidemia Collapse << | Phase 4 | Completed | - | Spain ... more >> Hospital Universitari Sant Joan Reus, Tarragona, Spain, 43204 Collapse << |
NCT01010516 | Dyslipidemia | Phase 4 | Unknown | - | Greece ... more >> University of Ioannina Medical School Recruiting Ioannina, Greece, 45 110 Contact: M S Elisaf, MD +302651007509 egepi@cc.uoi.gr Principal Investigator: Moses S Elisaf, MD Sub-Investigator: Evangelos N Liberopoulos, MD Sub-Investigator: Anastazia Kei, MD Collapse << |
NCT00533208 | Seasonal Allergies | Phase 2 | Completed | - | - |
NCT00961636 | - | - | Completed | - | - |
NCT00111891 | Dyslipidemia | Phase 2 | Completed | - | - |
NCT00376584 | Hypercholesteremia ... more >> Hyperlipidemia Collapse << | Phase 3 | Completed | - | - |
NCT00961636 | Dyslipidemia | Phase 3 | Completed | - | - |
NCT01942291 | Hypoalphalipoproteinemia | Phase 4 | Completed | - | Brazil ... more >> University of Campinas Campinas, SP, Brazil, 13083-887 Collapse << |
NCT00269204 | Primary Hypercholesterolaemia ... more >> Mixed Hyperlipidaemia Collapse << | Phase 3 | Completed | - | - |
NCT00289900 | Mixed Hyperlipidemia | Phase 3 | Completed | - | - |
NCT01052311 | Coronary Artery Disease ... more >> Dyslipidemia Collapse << | Phase 4 | Terminated(The sponsor decided... more >> to withdraw study drug from market) Collapse << | - | Israel ... more >> Leviev Heart Center, Sheba Medical Center Tel Hashomer, Israel, 52621 Collapse << |
NCT01414166 | - | - | Terminated(In HPS2-THRIVE, MK-... more >>0524A did not meet the primary efficacy objective and there was a significant increase in incidence of some types of non-fatal SAEs) Collapse << | - | - |
NCT01414166 | Dyslipidemia | Phase 3 | Terminated(In HPS2-THRIVE, MK-... more >>0524A did not meet the primary efficacy objective and there was a significant increase in incidence of some types of non-fatal SAEs) Collapse << | - | - |
NCT00289900 | - | - | Completed | - | - |
NCT00461630 | Cardiovascular Disease ... more >> Peripheral Arterial Disease Diabetes Mellitus Coronary Heart Disease Collapse << | Phase 3 | Completed | - | United Kingdom ... more >> Clinical Trial Service Unit, University of Oxford Oxford, United Kingdom, OX3 7LF Collapse << |
NCT00536237 | Flushing | Phase 2 | Completed | - | - |
NCT00533312 | Hypercholesterolemia | Phase 2 | Completed | - | - |
NCT00384293 | - | - | Terminated | - | - |
NCT00378833 | Hypercholesterolemia ... more >> Hyperlipidemia Collapse << | Phase 3 | Completed | - | - |
NCT00461630 | - | - | Completed | - | - |
NCT00738985 | Cardiovascular Diseases ... more >> Hyperlipidemia Collapse << | Phase 4 | Withdrawn(The study was cancel... more >>led due to budget limitations) Collapse << | - | - |
NCT00269217 | Primary Hypercholesterolemia ... more >> Mixed Hyperlipidemia Collapse << | Phase 3 | Completed | - | - |
NCT00384293 | Hypercholesterolemia, Familial | Phase 3 | Terminated | - | - |
NCT00479882 | Primary Hypercholesterolemia ... more >> Mixed Dyslipidemia Collapse << | Phase 3 | Completed | - | - |
NCT00533611 | Flushing | Phase 3 | Completed | - | - |
NCT00769132 | Hypercholesterolemia | Phase 1 | Completed | - | - |
NCT00479882 | - | - | Completed | - | - |
NCT00618995 | Type 2 Diabetes Mellitus | Phase 1 | Completed | - | - |
NCT00618995 | - | - | Completed | - | - |
NCT01335997 | Primary Hypercholesterolemia ... more >> Mixed Dyslipidemia Collapse << | Phase 3 | Terminated(Business Reasons) | - | - |
NCT01335997 | - | - | Terminated(Business Reasons) | - | - |
NCT00783601 | Asthma | Phase 2 | Completed | - | - |
NCT00769132 | - | - | Completed | - | - |
NCT01321034 | Hypercholesterolemia | Phase 4 | Completed | - | Spain ... more >> Hospital San Jorge Huesca, Spain Hospital Universitario Miguel Servet Zaragoza, Spain, 50009 Hospital Royo Villanova Zaragoza, Spain Collapse << |
NCT01012219 | Primary Hypercholesterolemia ... more >> Mixed Hyperlipidemia Collapse << | Phase 1 | Completed | - | - |
NCT01012219 | - | - | Completed | - | - |
NCT00479388 | Primary Hypercholesterolemia ... more >> Mixed Dyslipidemia Collapse << | Phase 3 | Completed | - | - |
NCT00536510 | Hypercholesterolemia ... more >> Hyperlipidemia Collapse << | Phase 3 | Completed | - | - |
NCT00536510 | - | - | Completed | - | - |
NCT01274559 | - | - | Terminated(In HPS2-THRIVE, MK-... more >>0524A did not meet the primary efficacy objective and there was a significant increase in incidence of some types of non-fatal SAEs) Collapse << | - | - |
NCT00479388 | - | - | Completed | - | - |
NCT01274559 | Primary Hypercholesterolemia ... more >> Mixed Dyslipidemia Collapse << | Phase 3 | Terminated(In HPS2-THRIVE, MK-... more >>0524A did not meet the primary efficacy objective and there was a significant increase in incidence of some types of non-fatal SAEs) Collapse << | - | - |
NCT01683656 | HIV Atheroscl... more >>erosis Collapse << | Phase 4 | Terminated(Withdrawal of IMP f... more >>rom the market. Data on risk-benefit ratio pending.) Collapse << | July 2014 | Switzerland ... more >> University Hospital Berne Inselspital Berne, BE, Switzerland, 3010 University Hospital Basel Basel, BS, Switzerland, 4031 University Hospitals Genève Geneva, GE, Switzerland, 1211 Kantonsspital St Gallen St Gallen, SG, Switzerland, 9007 EOC Ente Ospedaliero Cantonale, civico Lugano, TI, Switzerland, 6903 CHUV Cantonal University Hospital Vaud Lausanne, VD, Switzerland, 1011 University Hospital Zurich Zurich, ZH, Switzerland Collapse << |
NCT01228019 | - | - | Terminated(In HPS2-THRIVE, MK-... more >>0524A did not meet the primary efficacy objective and there was a significant increase in incidence of some types of non-fatal SAEs) Collapse << | - | - |
NCT01239992 | - | - | Terminated(negative endpoint s... more >>tudy resulting in withdrawal of study drug) Collapse << | - | - |
NCT01239992 | Hyperlipoproteinemia ... more >> Metabolic Syndrome Collapse << | Phase 4 | Terminated(negative endpoint s... more >>tudy resulting in withdrawal of study drug) Collapse << | - | Germany ... more >> Medizinische Klinik II, Klinikum der Universitaet Muenchen, Grosshadern Munich, Germany, 81377 Collapse << |
NCT01228019 | - | - | Terminated(In HPS2-THRIVE, MK-... more >>0524A did not meet the primary efficacy objective and there was a significant increase in incidence of some types of non-fatal SAEs) Collapse << | - | - |
NCT01451619 | Rosacea | Phase 1 | Completed | - | - |
NCT01308203 | Coronary Artery Disease ... more >> Dyslipidemias Collapse << | Phase 4 | Terminated(Merck has decided t... more >>o discontinue all studies with extended-release niacin/laropiprant.because the HPS2-THRIVE did not meet its primary endpoint) Collapse << | - | Argentina ... more >> Hospital Italiano de Buenos Aires Buenos Aires, Argentina, C1181ACH Collapse << |
NCT01294683 | Primary Hypercholesterolemia ... more >> Dyslipidemia Collapse << | Phase 3 | Terminated | - | - |
NCT01294683 | - | - | Terminated | - | - |
NCT00944645 | - | - | Completed | - | - |
NCT00944645 | Dyslipidemia | Phase 1 | Completed | - | - |
NCT00485758 | - | - | Completed | - | - |
NCT00943124 | Dyslipidemia | Phase 1 | Completed | - | - |
NCT01126073 | Coronary Heart Disease | Phase 4 | Completed | - | Slovenia ... more >> UMC Ljubljana Ljubljana, Slovenia, 1000 Collapse << |
NCT00943124 | - | - | Completed | - | - |
NCT00485758 | Diabetes Mellitus Type 2 | Phase 3 | Completed | - | - |
NCT00664287 | Dyslipidemia | Phase 3 | Withdrawn | - | - |
NCT01583647 | - | - | Terminated(In HPS2-THRIVE, MK-... more >>0524A did not meet the primary efficacy objective and there was a significant increase in incidence of some types of non-fatal SAEs.) Collapse << | - | - |
NCT01583647 | Hypercholesterolemia, Familial... more >> Heterozygous Familial Hypercholesterolemia Collapse << | Phase 1 | Terminated(In HPS2-THRIVE, MK-... more >>0524A did not meet the primary efficacy objective and there was a significant increase in incidence of some types of non-fatal SAEs.) Collapse << | - | - |
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