CAS No.: 454453-49-7
Kobe2602 Catalog No. CSN15978
Synonyms: Kobe2602
Kobe2602 is an effective small-molecule compound inhibiting Ras–Raf interaction by SBDD exhibiting potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 149 ± 55 μM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Shima, Fumi, et al. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proceedings of the National Academy of Sciences of the United States of America (2013), 110(20), 8182-8187, S8182/1-S8182/10.
- [2] Shima F, Yoshikawa Y, et al. Discovery of small-molecule Ras inhibitors that display antitumor activity by interfering with Ras·GTP-effector interaction. Enzymes. 2013;34 Pt. B:1-23.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 454453-49-7 | 储存条件 |
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| 分子式 | C14H9F4N5O4S | 运输 | 蓝冰 | |
| 分子量 | 419.31 | 别名 | Kobe2602 |
