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CAS No.: 304481-60-5

KM91104 is a specific v-ATPase inhibitor. It specifically targets the interaction between v-ATPase subunit a3 and subunit B2.

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描述The vacuolar H⁺ adenosine-triphosphatase (v-ATPase) multi-subunit complex is a key regulator of intracellular pH homeostasis. KM91104 is a cell-permeable inhibitor of v-ATPase. In hHSC (human hepatic stellate cells), KM91104 (1 nM and 10 nM; 48 hr) reduced v-ATPase expression and activity. Serum starved hHSC displayed a higher neutral red uptake compared to cells in complete medium reflecting a more acidic pH inside the lysosomes and endosomes. KM91104 (10 nM) in serum free condition reversed this effect as demonstrated by a decreased uptake of neutral red when compared to the control cells. Likewise, treatment with 10 nM KM91104 was followed by a significant decrease in cytosolic pH. Specific inhibition of v-ATPase with KM91104 induced a down-regulation of the HSC fibrogenic gene profile, which coincided with increased lysosomal pH, decreased pHi, activation of AMPK, reduced proliferation, and lower metabolic activity^[3].
作用机制KM91104 specifically targets the interaction between v-ATPase subunit a3 and subunit B2^[3].
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技术信息

CAS号

304481-60-5

储存条件

分子式

C14H12N2O4

运输

蓝冰

分子量

272.26

别名

溶解度

动物实验配方

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