CAS No.: 99624-27-8
Kazinol B/小构树醇B Catalog No. CSN14822
Synonyms: 小构树醇B
Kazinol B, a natural product isolated and purified from the barks of Broussonetia papyrifera, inhibits the NO synthesis with an IC(50) of 21.6 mM, stimulates respiratory burst, is probably mediated by the synergism of PKC activation and [Ca2+]i elevation in rat neutrophils, stimulates Ca(2+) release from internal Ca(2+) store, probably through the sphingosine 1-phosphate and IP(3) signaling, activates external Ca(2+) influx mainly through a non-store-operated Ca(2+) entry (non-SOCE) pathway, and inhibits SOCE, probably attributable to a break in the Ca(2+) driven force of mitochondria.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Wang JP, Hsu MF, et al. Stimulation of cellular free Ca2+ elevation and inhibition of store-operated Ca2+ entry by kazinol B in neutrophils. Naunyn Schmiedebergs Arch Pharmacol. 2004 Dec;370(6):500-9.
- [2] Ryu JH, Ahn H, Jin Lee H. Inhibition of nitric oxide production on LPS-activated macrophages by kazinol B from Broussonetia kazinoki. Fitoterapia. 2003 Jun;74(4):350-4.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 99624-27-8 | 储存条件 |
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| 分子式 | C25H28O4 | 运输 | 蓝冰 | |
| 分子量 | 392.49 | 别名 | 小构树醇B |
