|5,7-二羟基-2-(4-羟基苯基)-3-((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(((2R,3R,4R,5R,6S)-3,4,5-三羟基-6-甲基四氢-2H-吡喃-2-基)氧基)甲基四氢-2H-吡喃-2-基)氧基)-4H-苯并吡喃-4-酮|CsnPharm

CAS No.: 17650-84-9

Kaempferol-3-O-rutinoside/山柰酚-3-O-芸香糖苷 Catalog No. CSN11244

Synonyms: Nikotoflorin;Kaempferol 3-O-β-rutinoside;3,4′,5,7-Tetrahydroxyflavone 3-rhamnoglucoside

Nicotiflorin, a natural product isolated and purified from the herb of Carthamus tinctorius L., has protective effects on reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats.

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400-920-2911

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生物活性

描述Nicotiflorin is a single component extracted from traditional Chinese medicine Flos Carthami. At doses of 2.5, 5 and 10 mg/kg, nicotiflorin administered immediately after the onset of ischemia markedly reduced brain infarct volume and neurological deficits. For primarily cultured neurons suffered 2 h hypoxia followed by 24 h reoxygenation, nicotiflorin significantly attenuated cell death and reduced LDH release^[3]. In vivo, nicotiflorin treatment alleviated brain damage and neurological deficit while it dramatically increased 72 h survival rate in rats. In vitro, nicotiflorin treatment also ameliorated the severity of OGD/R(oxygen-glucose deprivation and reintroduction). In vitro, nicotiflorin likewise enhanced autophagy and promoted autophagy flux^[4]. Nicotiflorin (10 mg/kg) protects against cerebral ischemia/reperfusion injury-induced apoptosis via the JAK2/STAT3 pathway^[5]. Nicotiflorin and rutin showed neuroprotective effects on hypoxia-, glutamate- or oxidative stress-induced RGC (retinal ganglion cell) death at concentrations of 1 nM or higher^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.6820 mL
- 8.4102 mL
- 16.8203 mL
- 5 mM
- 0.3364 mL
- 1.6820 mL
- 3.3641 mL
- 10 mM
- 0.1682 mL
- 0.8410 mL
- 1.6820 mL

技术信息

CAS号

17650-84-9

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C27H30O15

运输

蓝冰

分子量

594.52

别名

Nikotoflorin;Kaempferol 3-O-β-rutinoside;3,4′,5,7-Tetrahydroxyflavone 3-rhamnoglucoside;山柰酚-3-O-芸香糖苷

溶解度

DMSO	100.0 mg/mL (168.2 mM)

动物实验配方

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Kaempferol-3-O-rutinoside/山柰酚-3-O-芸香糖苷 Catalog No. CSN11244

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