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CAS No.: 482-38-2

Kaempferitrin/山奈苷 Catalog No. CSN11241

Synonyms: Lespedin;Lespenephryl;BRN 0073958

Kaempferitrin can activate insulin signaling pathway, phosphorylate Akt kinase and exert the transloocation of GLUT4, thus has antitumor, antidepressant and antidiabetic effects. Kaempferitrin is a natural product isolated and purified from the root of Kaempferia galangal L..

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技术信息

生物活性

描述Kaempferitrin (KM) is a natural flavonoid, possesses antinociceptive, anti-inflammatory, anti-diabetic, antitumoral and chemopreventive effects, and activates insulin signaling pathway. Kaempferitrin causes survival rates higher than 90% at 1-20 μM in matured 3T3-L1 adipocyte, and the survival rates decline rapidly at 25 and 50 μM. Kaempferitrin (15 μM) increases insulin receptor beta tyrosine phosphorylation and tyrosine phosphorylation of the insulin receptor substrate 1, and such effects are similar to that of 10 nM insulin. In addition, Kaempferitrin increases the total levels of Glu4 protein in differentiated cells and secreted adiponectin in mature 3T3-L1 adipocytes^[3]. KM induces high cytotoxic effects in vitro and in vivo against HeLa cells. Kaempferitrin (2.5, 10 and 25 mg/kg, i.p.) markedly suppresses the growth of tumor by 40%, 87% and 97%, and decreases tumor weight by 37%, 81% and 95%, respectively in nu/nu mice bearing HeLa tumor^[4]. Kaempferitrin decreased the levels of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, matrix metalloproteinase (MMP)-1, and MMP-3 in MH7A cells. Moreover, kaempferitrin blocked the activation of nuclear factor-κB (NF-κB) and protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathways. Furthermore, treatment with kaempferitrin decreased paw thickness and arthritis scores, and reduced the serum levels of IL-1β, IL-6, and TNF-α in a collagen-induced arthritis mouse model^[5]. KM effectively increased SOD (Superoxide dismutase) activity, decreased MDA (malondialdehyde) levels, suppressed ROS (Reactive oxygen species) generation, and protected against OS (oxidative stress) in AGE-induced (Advanced glycation end products) GMCs^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7286 mL
- 8.6428 mL
- 17.2855 mL
- 5 mM
- 0.3457 mL
- 1.7286 mL
- 3.4571 mL
- 10 mM
- 0.1729 mL
- 0.8643 mL
- 1.7286 mL

技术信息

CAS号

482-38-2

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C27H30O14

运输

蓝冰

分子量

578.52

别名

Lespedin;Lespenephryl;BRN 0073958;Grosvenorine II;Kaempferol 3,7-O-α-Dirhamnoside;4-18-00-03292 (Beilstein Handbook Reference);Kaempferol 3,7-bisrhamnoside;山奈苷

溶解度

DMSO	100.0 mg/mL (172.9 mM)

动物实验配方

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Kaempferitrin/山奈苷 Catalog No. CSN11241

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