|4-甲基-N1-(3-苯基丙基)-1,2-苯二胺|CsnPharm

CAS No.: 749886-87-1

JSH-23/4-甲基-N1-(3-苯丙基)-1,2-苯二胺 Catalog No. CSN16019

Synonyms: NF-κB Activation Inhibitor II

JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM in RAW 264.7 cell line.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 NF-κB

IC50:7.1μM
描述NF-κB is a transcription factor with heterodimer or homodimer form of rel family proteins including RelA (p65), RelB, cRel, p50 and p52. JSH-23 is an NF-κB inhibitor with IC50 value of 7.1μM for inhibition of LPS-induced activation of NF-κB transcriptional activity in macrophages RAW 264.7 cells without affecting Iκα degradation. Treatment with JSH-23 at concentration of 3-30μM for 1h led to reduced LPS-induced nuclear translocation of NF-κB p65 and DNA binding activity of NF-κB in macrophages RAW 264.7 cells, as well as NF-κB mediated reporter gene expression at time for 16h. JSH-23 at concentration ranging in 3-30μM could dose-dependently suppress LPS-induced expressions of pro-inflammatory cytokines, including TNF-α, IL-1β and IL-6 and enzymes including iNOS and COX-2 on mRNA level. I.C.V. infusion of JSH-23 (15μg per 2.5μL per rat) could block the hippocampal neurogenesis induced by CUS (chronic unpredictable stress) in rats.
动物研究
剂量
Rat: 1 mg/kg - 3 mg/kg^[3] (p.o.) Mice: 20 mg/kg, 40 mg/kg^[4] (i.p.)

给药途径
p.o., i.p.

动物研究
剂量	Rat: 1 mg/kg - 3 mg/kg^[3] (p.o.) Mice: 20 mg/kg, 40 mg/kg^[4] (i.p.)
给药途径	p.o., i.p.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.1607 mL
- 20.8036 mL
- 41.6071 mL
- 5 mM
- 0.8321 mL
- 4.1607 mL
- 8.3214 mL
- 10 mM
- 0.4161 mL
- 2.0804 mL
- 4.1607 mL

技术信息

CAS号

749886-87-1

储存条件

粉末: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H20N2

运输

蓝冰

分子量

240.34

别名

NF-κB Activation Inhibitor II

溶解度

DMSO	900.0 mg/mL (3744.6 mM)
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+40% PEG300+water	9 mg/mL	clear
PO	0.5% CMC-Na	30 mg/mL	suspension

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JSH-23/4-甲基-N1-(3-苯丙基)-1,2-苯二胺 Catalog No. CSN16019

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