CAS No.: 459168-41-3
JNJ-7777120 Catalog No. CSN16759
Synonyms: JNJ-7777120
JNJ-7777120 is a selective antagonist of histamine-4 receptor (H4R) with Ki of 4 ± 1 nM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Rosa AC, Pini A, et al. Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ7777120 treatment. J Pharmacol Exp Ther. 2014 Nov;351(2):308-16.
- [2] Jablonowski JA, Grice CA, et al. The first potent and selective non-imidazole human histamine H4 receptor antagonists. J Med Chem. 2003 Sep 11;46(19):3957-60.
- [3] Thurmond RL. The histamine H4 receptor: from orphan to the clinic. Front Pharmacol. 2015;6:65.
- [4] Jablonowski JA, Grice CA, Chai W, et al. The first potent and selective non-imidazole human histamine H4 receptor antagonists. J Med Chem. 2003;46(19):3957-3960.
- [5] Thurmond RL, Desai PJ, Dunford PJ, et al. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther. 2004;309(1):404-413.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 459168-41-3 | 储存条件 |
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| 分子式 | C14H16ClN3O | 运输 | 蓝冰 | |||||||||
| 分子量 | 277.75 | 别名 | JNJ-7777120 | |||||||||
| 溶解度 |
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动物实验配方 |
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