CAS No.: 2091134-35-7
JAK1-IN-4 Catalog No. CSN20396
Synonyms: LM-5277;AZD-4205
AZD4205 is a potent ATP-competitive inhibitor that inhibits JAK1 with a Ki of 2.8 nM and exhibits excellent selectivity compared with other JAK family kinases and across the kinome.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT03728023 Healthy Volunteers Phase 1 Not yet recruiting December 2019 - NCT03450330 Nonsmall Cell Lung Cancer Phase 1 Phase 2 Recruiting July 2022 Australia, Victoria ... more >> Austin Hospital Recruiting Heidelberg, Victoria, Australia, 3084 Contact: Sarah Healy Principal Investigator: Tom John Australia Northern Cancer Institute St Leonards Active, not recruiting Sydney, Australia, 2066 Collapse << - 参考文献
- [1] Jason G. Kettle, Qibin Su, et al. Discovery of the JAK1 selective kinase inhibitor AZD4205 [abstract] . In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 979.
- [2] Huawei (Ray) Chen, Geraldine Bebernitz, et al. Targeting jak/stat adaptive mechanism with jak1 inhibitor azd4205 reduces residual disease and prolongs benefit of osimertinib [abstract] . In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4046.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 2091134-35-7 | 储存条件 |
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| 分子式 | C26H32FN9O2 | 运输 | 蓝冰 | |
| 分子量 | 521.59 | 别名 | LM-5277;AZD-4205 |
