CAS No.: 873054-44-5
Ivacaftor/依伐卡托 Catalog No. CSN13698
Synonyms: VX-770;brand name: KALYDECO;Orkambi
Ivacaftor is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 CFTR (F508del)
EC50:25nMCFTR (G551D)
EC50:100nM- 描述
- 作用机制
- 细胞研究
- Cell Data
- 更多
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT03525548 Cystic Fibrosis Phase 3 Active, not recruiting March 2019 - NCT03447249 Cystic Fibrosis Phase 3 Active, not recruiting April 16, 2019 - NCT03525574 Cystic Fibrosis Phase 3 Enrolling by invitation June 2021 - - 更多
- 参考文献
- [1] Van Goor F, Hadida S, et al. Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770. Proc Natl Acad Sci U S A. 2009;106(44):18825-30.
- [2] Jih KY, Hwang TC. Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle. Proc Natl Acad Sci U S A. 2013;110(11):4404-9.
- [3] Eckford PD, Li C, et al. Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner. J Biol Chem. 2012;287(44):36639-49.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 873054-44-5 | 储存条件 |
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| 分子式 | C24H28N2O3 | 运输 | 蓝冰 | |||||||||||||
| 分子量 | 392.49 | 别名 | VX-770;brand name: KALYDECO;Orkambi;依伐卡托 | |||||||||||||
| 溶解度 |
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动物实验配方 |
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| Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
|---|
| CFBE41o- | 10 µM | Function Assay | - | induces robust increases in anion transport | 22768130 |
| HBE | 10 μM | Function Assay | 10 min | augments CFTR-dependent ion transport | 24106801 |
| HBE | 10 µM | Function Assay | - | augments CFTR-dependent anion transport activity | 22768130 |
| HBE | 10 µM | Function Assay | 24 h | induces a modest but significant increase in ASL depth | 22768130 |
| HBE | 10 µM | Function Assay | - | potentiates CFTR-dependent Isc, regardless of prior administration of CSE | 22768130 |
| HBE | 10 µM | Function Assay | - | partially restores depletion of ASL depth in CSE treated monolayers | 22768130 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
|---|
| NCT03525548 | Cystic Fibrosis | Phase 3 | Active, not recruiting | March 2019 | - |
| NCT03447249 | Cystic Fibrosis | Phase 3 | Active, not recruiting | April 16, 2019 | - |
| NCT03525574 | Cystic Fibrosis | Phase 3 | Enrolling by invitation | June 2021 | - |
| NCT03506061 | Cystic Fibrosis | Phase 2 | Not yet recruiting | May 2023 | United States, Alabama ... more >> University of Alabama Cystic Fibrosis Research Center Not yet recruiting Birmingham, Alabama, United States, 35233 Contact: George Soloman, MD 205-975-9776 msolomon@uab.edu United States, Georgia Emory Children's Center Not yet recruiting Atlanta, Georgia, United States, 30322 Contact: Eric Sorscher, MD 205-612-1327 esorscher@emory.edu Collapse << |
| NCT03447262 | Cystic Fibrosis | Phase 3 | Enrolling by invitation | April 24, 2021 | - |
| NCT03587961 | Cystic Fibrosis | Early Phase 1 | Not yet recruiting | January 1, 2021 | United States, Alabama ... more >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35233 Collapse << |
| NCT02951182 | Cystic Fibrosis | Phase 2 | Completed | - | - |
| NCT02392702 | Healthy | Phase 1 | Completed | - | Australia, South Australia ... more >> CMAX Adelaide, South Australia, Australia, 5000 Collapse << |
| NCT02599792 | Healthy | Phase 1 | Completed | - | Australia, South Australia ... more >> Adelaide, South Australia, Australia, 5000 Collapse << |
| NCT03445793 | - | - | Recruiting | December 31, 2019 | United States, Colorado ... more >> National Jewish Heatlh Recruiting Denver, Colorado, United States, 80206 Contact: Terri Herrud, BS 303-398-1453 herrudt@njhealth.org Collapse << |
| NCT02997020 | - | - | Recruiting | May 2022 | United States, Alabama ... more >> University of Alabama at Birmingham Recruiting Birmingham, Alabama, United States, 35294 Contact: Lisa Clemons, RN, MSN 205-934-9714 lkclemons@uabmc.edu Collapse << |
| NCT02589236 | Cystic Fibrosis | Phase 2 | Completed | - | - |
| NCT02311140 | - | - | Unknown | January 2018 | Germany ... more >> Jena University Hospital, CF Center Recruiting Jena, Germany, 07743 Contact: Jochen G Mainz, MD, PD +493641938425 jochen.mainz@med.uni-jena.de Collapse << |
| NCT02722057 | - | - | Active, not recruiting | December 2019 | - |
| NCT01549314 | - | - | Active, not recruiting | December 2018 | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Collapse << |
| NCT02871778 | Primary Ciliary Dyskinesia | Phase 2 | Active, not recruiting | April 2019 | - |
| NCT03045523 | Cystic Fibrosis | Phase 2 | Completed | - | Australia ... more >> The Prince Charles Hospital Chermside, Australia The Alfred Melbourne, Australia Sir Charles Gairdner Hospital Nedlands, Australia Westmead Hospital Westmead, Australia Belgium UZ Brussel Brussels, Belgium UZ Gent Ghent, Belgium UZ Leuven Leuven, Belgium Czechia Fakultni nemocnice v Motole Praha, Czechia Germany Universitaetsklinikum Carl Gustav Carus TU Dresden Dresden, Germany Universitätsklinikum Erlangen Erlangen, Germany University Children´s Hospital Tübingen, Germany Ireland Cork University Hospital Cork, Ireland Beaumont Hospital Dublin, Ireland St Vincents University Hospital Dublin, Ireland United Kingdom Birmingham Heartlands Birmingham, United Kingdom Royal Devon and Exeter Exeter, United Kingdom St James's University Leeds, United Kingdom Liverpool Heart and Chest Hospital Liverpool, United Kingdom Royal Brompton Hospital London, United Kingdom University Hospital of South Manchester Manchester, United Kingdom Royal Victoria Infirmary Newcastle, United Kingdom Southampton General Hospital Southampton, United Kingdom Collapse << |
| NCT03537651 | Cystic Fibrosis | Phase 3 | Enrolling by invitation | December 2020 | - |
| NCT02445053 | - | - | Active, not recruiting | December 2020 | Italy ... more >> Bari, Italy Messina, Italy Milano, Italy Milan, Italy Naples, Italy Potenza, Italy Verona, Italy Netherlands Den Haag, South Holland, Netherlands Amsterdam, Netherlands Gronningen, Netherlands Heidelberglaan, Netherlands Nijmegen, Netherlands Rotterdam, Netherlands United Kingdom London, Greater London, United Kingdom Birmingham, West Midlands, United Kingdom Collapse << |
| NCT02347657 | Cystic Fibrosis | Phase 3 | Completed | - | - |
| NCT03559062 | Cystic Fibrosis | Phase 3 | Recruiting | February 2019 | Australia ... more >> Hunter Medical Research Institute (HMRI) Recruiting New Lambton Heights, Australia Princess Margaret Hospital for Children Recruiting Perth, Australia Lady Cilento Children's Hospital Recruiting South Brisbane, Australia The Children's Hospital at Westmead Recruiting Westmead, Australia Belgium Universitair Ziekenhuis Brussel - Campus Jette Recruiting Brussels, Belgium Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg Recruiting Leuven, Belgium Denmark University of Copenhagen Rigshospitalet Recruiting Copenhagen, Denmark France Groupe Hospitalier Pellegrin - Hôpital des Enfants Recruiting Bordeaux Cedex, France Hôpital Necker - Enfants Malades Recruiting Paris, France Germany Universitaetsklinikum Essen Recruiting Essen, Germany Klinikum der Johann Wolfgang Goethe-Universitaet Recruiting Frankfurt, Germany Universitaetsklinikum Giessen und Marburg GmbH Standort Giessen Recruiting Giessen, Germany Medizinische Hochschule Hannover Recruiting Hannover, Germany Universitaetsklinikum Heidelberg Recruiting Heidelberg, Germany Universitaetsklinikum Jena Recruiting Jena, Germany Universitaetsklinikum Koeln Not yet recruiting Koeln, Germany Universitaetsklinikum Tuebingen Recruiting Tuebingen, Germany Ireland Our Lady's Children's Hospital Recruiting Dublin, Ireland University Hospital Limerick Recruiting Limerick, Ireland Poland Klinika Mukowiscydozy, Oddział Chorób Płuc SZP ZOZ Recruiting Dziekanow Lesny, Poland Switzerland Inselspital - Universitaetsspital Bern Recruiting Bern, Switzerland Kinderspital Zuerich Recruiting Zuerich, Switzerland United Kingdom Royal Hospital for Sick Children Recruiting Edinburgh, United Kingdom Leeds General Infirmary Recruiting Leeds, United Kingdom Royal Brompton Hospital Recruiting London, United Kingdom Nottingham University Hospital City Campus Recruiting Nottingham, United Kingdom Southampton General Hospital Recruiting Southampton, United Kingdom Collapse << |
| NCT01381289 | - | - | - | - | - |
| NCT03256968 | Cystic Fibrosis | Phase 4 | Active, not recruiting | December 31, 2018 | United States, Alabama ... more >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35233 Collapse << |
| NCT02724527 | Cystic Fibrosis | Phase 2 | Unknown | April 2017 | United States, Colorado ... more >> National Jewish Health Denver, Colorado, United States, 80206 United States, Maryland Johns Hopkins Hospital Baltimore, Maryland, United States, 21287 United States, Massachusetts Boston Children's Hospital Boston, Massachusetts, United States, 02115 United States, Missouri Washington University St. Louis, Missouri, United States, 63110 United States, New York Columbia University New York, New York, United States, 10032 United States, Ohio Cincinnati Children's Hospital Cincinnati, Ohio, United States, 45229 Rainbow Babies and Children's Hospital - Case Medical Center Cleveland, Ohio, United States, 44106 Nationwide Children's Hospital Columbus, Ohio, United States, 43205 United States, Oregon Oregon Health and Science University Portland, Oregon, United States, 97239 United States, Pennsylvania Children's Hospital Pittsburgh Pittsburgh, Pennsylvania, United States, 15224 United States, Utah University of Utah Salt Lake City, Utah, United States, 84132 United States, Wisconsin Medical Center of Wisconsin Madison, Wisconsin, United States, 53792 Collapse << |
| NCT03624101 | Cystic Fibrosis | Early Phase 1 | Recruiting | November 1, 2021 | United States, Alabama ... more >> University of Alabama at Birmingham Recruiting Birmingham, Alabama, United States, 35233 Contact: Heather R Hathorne, MAE, RRT 205-939-9568 hhathorne@peds.uab.edu Principal Investigator: Steven M Rowe, MD, MpH Collapse << |
| NCT02875366 | Cystic Fibrosis | Phase 4 | Completed | - | Australia, Victoria ... more >> Melbourne, Victoria, Australia Parkville, Victoria, Australia Australia Adelaide, Australia Camperdown, Australia Clayton, Australia Nedlands, Australia New Lambton Heights, Australia Randwick, Australia South Brisbane, Australia Subiaco, Australia Westmead, Australia United Kingdom Edinburgh, United Kingdom Collapse << |
| NCT02347657 | - | - | Completed | - | - |
| NCT03061331 | - | - | Completed | - | - |
| NCT03061331 | Cystic Fibrosis | Phase 2 | Completed | - | Netherlands ... more >> HagaZiekenhuis Den Haag, Netherlands University Medical Center, Utrecht, Department of Pulmonology and Tuberculosis Heidelberglaan, Netherlands Collapse << |
| NCT02141464 | - | - | Completed | - | United States, Pennsylvania ... more >> Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Collapse << |
| NCT02070744 | Cystic Fibrosis | Phase 2 | Completed | - | - |
| NCT00966602 | Cystic Fibrosis | Phase 1 | Completed | - | Netherlands ... more >> Zuidlaren, Netherlands Collapse << |
| NCT03390985 | - | - | Completed | - | - |
| NCT02070744 | - | - | Completed | - | - |
| NCT03278314 | - | - | - | - | - |
| NCT01216046 | Cystic Fibrosis | Phase 1 | Completed | - | United States, Kansas ... more >> PRA Lenexa, Kansas, United States, 66219 Collapse << |
| NCT01225211 | Cystic Fibrosis | Phase 2 | Completed | - | - |
| NCT01208285 | In Development for Cystic Fibr... more >>osis Collapse << | Phase 1 | Completed | - | Czech Republic ... more >> Hradec Králové, Czech Republic Praha, Czech Republic Slovakia Bratislava, Slovakia Collapse << |
| NCT01910415 | Cystic Fibrosis | Phase 1 | Completed | - | Netherlands ... more >> Zuidlaren, Netherlands Collapse << |
| NCT01060566 | Cystic Fibrosis | Phase 1 | Completed | - | United States, Florida ... more >> Covan CRU, Inc. Daytona Beach, Florida, United States, 32117 Collapse << |
| NCT02039986 | - | - | Completed | - | United States, Pennsylvania ... more >> The Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Collapse << |
| NCT01531673 | Cystic Fibrosis | Phase 2 | Completed | - | - |
| NCT03601637 | Cystic Fibrosis | Phase 3 | Recruiting | September 2020 | United States, Alabama ... more >> University of Alabama at Birmingham Recruiting Birmingham, Alabama, United States, 35294 United States, Arkansas Arkansas Children's Hospital Recruiting Little Rock, Arkansas, United States, 72202 United States, Illinois Ann & Robert Lurie Children's Hospital of Chicago Recruiting Chicago, Illinois, United States, 60611 United States, Indiana Riley Hospital for Children at Indiana University Health Recruiting Indianapolis, Indiana, United States, 46202 United States, Massachusetts Boston Children's Hospital Recruiting Boston, Massachusetts, United States, 02115 United States, Minnesota Children's Respiratory and Critical Care Specialists, P.A., Children's Hospitals and Clinics of Minnesota Recruiting Minneapolis, Minnesota, United States, 55404 United States, Missouri The Children's Mercy Hospital Recruiting Kansas City, Missouri, United States, 64108 United States, New York Albany Medical College Recruiting Albany, New York, United States, 12208 United States, Pennsylvania Children's Hospital of Philadelphia Recruiting Philadelphia, Pennsylvania, United States, 19104 United States, Texas Cook Children's Medical Center Recruiting Fort Worth, Texas, United States, 76104 United States, Utah University of Utah / Primary Children's Medical Center Recruiting Salt Lake City, Utah, United States, 84132 United States, Washington Seattle Children's Hospital Recruiting Seattle, Washington, United States, 98105 United States, Wisconsin University of Wisconsin Hospital and Clinics Recruiting Madison, Wisconsin, United States, 53792 Canada British Columbia's Children's Hospital Recruiting Vancouver, Canada Collapse << |
| NCT01262352 | Cystic Fibrosis | Phase 2 | Completed | - | United States, California ... more >> Stanford, California, United States United States, Iowa Iowa City, Iowa, United States United States, North Carolina Durham, North Carolina, United States United States, Pennsylvania Pittsburgh, Pennsylvania, United States Canada, Ontario Toronto, Ontario, Canada United Kingdom Belfast, United Kingdom Edinburgh, United Kingdom London, United Kingdom Collapse << |
| NCT01153542 | In Development for Cystic Fibr... more >>osis Collapse << | Phase 1 | Completed | - | United States, Florida ... more >> Covance CRU, Inc. Daytona Beach, Florida, United States, 32117 Collapse << |
| NCT01262352 | - | - | Completed | - | - |
| NCT01018368 | Cystic Fibrosis | Phase 1 | Completed | - | United States, Florida ... more >> Daytona Beach, Florida, United States Collapse << |
| NCT03625466 | Cystic Fibrosis | Phase 2 | Recruiting | May 2021 | Germany ... more >> Charite Paediatric Pulmonology Department Recruiting Berlin, Germany Justus-Leibig-Universitat Zentrum fur Kinderheilkunde und Jugendmedizin Recruiting Giessen, Germany Hannover Medical School Recruiting Hannover, Germany Heidelberg Cystic Fibrosis Center Recruiting Heidelberg, Germany Universitatsklinikum Schleswig-Holstein, Klinik für Kinder- und Jugendmedizin Recruiting Lubeck, Germany Collapse << |
| NCT01225211 | - | - | Completed | - | - |
| NCT03486236 | Cystic Fibrosis | Phase 1 | Completed | - | United Kingdom ... more >> The Medicines Evaluation Unit Manchester, United Kingdom Collapse << |
| NCT03125395 | Cystic Fibrosis | Phase 3 | Active, not recruiting | July 26, 2019 | - |
| NCT03150719 | Cystic Fibrosis | Phase 3 | Completed | - | - |
| NCT02797132 | - | - | Completed | - | - |
| NCT03565692 | - | - | Recruiting | March 1, 2020 | France ... more >> CHU de Bordeaux - CRCM Recruiting Bordeaux, France, 33000 Contact: Mickael FAYON, MD,PhD mickael.fayon@chu-bordeaux.fr Principal Investigator: Mickael FAYON, MD,PhD Sub-Investigator: Patrick BERGER, MD,PhD Sub-Investigator: Raphael ENAUD, MD Centre Hospitalier Universitaire Grenoble Alpes Recruiting Grenoble, France, 38000 Contact: Catherine Llerena, MD CLlerena@chu-grenoble.fr Principal Investigator: Catherine Llerena, MD Sub-Investigator: Boubou Camara, MD CHRU de Lille Not yet recruiting Lille, France, 69000 Contact: Nathalie Wizla, MD nathalie.wizla@chru-lille.fr Principal Investigator: Nathalie Wizla, MD Sub-Investigator: Anne Prévotat, MD Hospices Civils de Lyon Not yet recruiting Lyon, France, 69000 Contact: Philippe Reix, MD philippe.reix@chu-lyon.fr Principal Investigator: Philippe Reix, MD Assistance publique Hôpitaux Marseille Recruiting Marseille, France, 13000 Contact: Jean Christophe Dubus, MD,PhD JeanChristophe.DUBUS@ap-hm.fr Principal Investigator: Jean Christophe Dubus, MD,PhD Assistance Publique Hôpitaux de paris Recruiting Paris, France, 75000 Contact: Harriet Corvol, MD,PhD harriet.corvol@aphp.fr Principal Investigator: Harriet Corvol, MD,PhD Sub-Investigator: Pierre-Regis BURGEL, MD Sub-Investigator: Isabelle Sermet-Gaudelus, MD,PhD Sub-Investigator: Michèle Gérardin Gérardin, MD Hôpital FOCH Recruiting Suresnes, France, 92150 Contact: Dominique Grenet, MD d.grenet@hopital-foch.org Principal Investigator: Dominique Grenet, MD CHU de Toulouse Recruiting Toulouse, France, 31000 Contact: Marlène Murris-Espin, MD murris.m@chu-toulouse.fr Contact: Murris-Espin Principal Investigator: Marlène Murris-Espin, MD Collapse << |
| NCT02516410 | Cystic Fibrosis | Phase 3 | Completed | - | - |
| NCT01531673 | - | - | Completed | - | - |
| NCT02516410 | - | - | Completed | - | - |
| NCT02730208 | Cystic Fibrosis | Phase 2 | Completed | - | Australia ... more >> Chermside, Australia Melbourne, Australia Nedlands, Australia New Lambton Heights, Australia Parkville SIC, Australia Randwick, Australia South Brisbane, Australia Subiaco, Australia Westmead, Australia Collapse << |
| NCT01931839 | Cystic Fibrosis, Homozygous or... more >> Heterozygous for the F508del-CFTR Mutation Collapse << | Phase 3 | Completed | - | - |
| NCT00457821 | - | - | Completed | - | - |
| NCT02508207 | Cystic Fibrosis | Phase 2 | Completed | - | United States, Alabama ... more >> Birmingham, Alabama, United States United States, Indiana Indianapolis, Indiana, United States United States, Maryland Baltimore, Maryland, United States United States, North Carolina Chapel Hill, North Carolina, United States United States, Ohio Cincinnati, Ohio, United States Toledo, Ohio, United States United States, Pennsylvania Pittsburgh, Pennsylvania, United States Collapse << |
| NCT00457821 | Cystic Fibrosis | Phase 2 | Completed | - | United States, Alabama ... more >> University of Alabama Hospital Birmingham, Alabama, United States, 35211 United States, California Stanford University Medical Center Palo Alto, California, United States, 34304 United States, Colorado The Children's Hospital Aurora, Colorado, United States, 80045 United States, Iowa Roy J. and Lucille A. Carver College of Medicine, The University of Iowa Iowa City, Iowa, United States, 52242-1083 United States, Maryland Johns Hopkins Hospital Baltimore, Maryland, United States, 21287 United States, Massachusetts Pulmonary and Critical Care Medicine, Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Children's Hospital of Boston Boston, Massachusetts, United States, 02215 United States, Minnesota Division of Pulmonary, Allergy and Critical Care Medicine, University of Minnesota Minneapolis, Minnesota, United States, 55455 United States, North Carolina Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill Chapel Hill, North Carolina, United States, 27599 United States, Ohio Rainbow Babies and Children's Hospital Cleveland, Ohio, United States, 44106 United States, Pennsylvania The Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104-4399 University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 United States, Washington Pulmonary Critical Care, University of Washington Seattle, Washington, United States, 98195 Canada, Ontario Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children Toronto, Ontario, Canada, M5G 1X8 Germany CF Clinic, Pediatric Pulmonology and Neonatology, Medical School of Hannover Strasse, Hannover, Germany, D-30625 Collapse << |
| NCT02508207 | - | - | Completed | - | - |
| NCT02797132 | Cystic Fibrosis | Phase 3 | Completed | - | - |
| NCT01931839 | - | - | Completed | - | - |
| NCT01807949 | Cystic Fibrosis, Homozygous fo... more >>r the F508del CFTR Mutation Collapse << | Phase 3 | Completed | - | - |
| NCT01807923 | Cystic Fibrosis, Homozygous fo... more >>r the F508del CFTR Mutation Collapse << | Phase 3 | Completed | - | - |
| NCT02953314 | Cystic Fibrosis | Phase 3 | Completed | - | - |
| NCT02392234 | Cystic Fibrosis | Phase 3 | Completed | - | - |
| NCT01888393 | Hepatic Impairment ... more >> Healthy Collapse << | Phase 1 | Completed | - | Czech Republic ... more >> Praha, Czech Republic Slovakia Bratislava, Slovakia Collapse << |
| NCT01807949 | - | - | Completed | - | - |
| NCT00909727 | Cystic Fibrosis | Phase 3 | Completed | - | - |
| NCT02514473 | - | - | Completed | - | - |
| NCT00909532 | Cystic Fibrosis | Phase 3 | Completed | - | - |
| NCT02392234 | - | - | Completed | - | - |
| NCT00909532 | - | - | Completed | - | - |
| NCT01807923 | - | - | Completed | - | - |
| NCT01768663 | Cystic Fibrosis | Phase 1 | Completed | - | United States, Indiana ... more >> Evansville, Indiana, United States Collapse << |
| NCT02514473 | Cystic Fibrosis | Phase 3 | Completed | - | - |
| NCT01161537 | Cystic Fibrosis | Phase 2 | Completed | - | United States, Virginia ... more >> Charlottesville, Virginia, United States Collapse << |
| NCT01117012 | Cystic Fibrosis | Phase 3 | Completed | - | - |
| NCT01161537 | - | - | Completed | - | - |
| NCT00909727 | - | - | Completed | - | - |
| NCT01117012 | - | - | Completed | - | - |
| NCT01937325 | Cystic Fibrosis | Phase 4 | Unknown | December 2016 | Australia, Victoria ... more >> The Alfred Melbourne, Victoria, Australia, 3004 Collapse << |
| NCT00953706 | Cystic Fibrosis | Phase 2 | Terminated(Following review of... more >> results obtained from a pre-specified 6-month analysis of Part B data the study was terminated on the basis of futility.) Collapse << | - | - |
| NCT02390219 | Cystic Fibrosis ... more >> Advanced Lung Disease Collapse << | Phase 3 | Completed | - | United States, Colorado ... more >> Denver, Colorado, United States United States, Florida Tampa, Florida, United States United States, Illinois Chicago, Illinois, United States United States, Missouri Saint Louis, Missouri, United States United States, Pennsylvania Pittsburgh, Pennsylvania, United States United States, Texas Houston, Texas, United States Collapse << |
| NCT00953706 | - | - | Terminated(Following review of... more >> results obtained from a pre-specified 6-month analysis of Part B data the study was terminated on the basis of futility.) Collapse << | - | - |
| NCT02390219 | - | - | Completed | - | - |
| NCT01863238 | - | - | Completed | - | - |
| NCT03256799 | Cystic Fibrosis | Phase 4 | Completed | - | United States, Alabama ... more >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35233 Collapse << |
| NCT01685801 | Cystic Fibrosis | Phase 2 | Completed | - | United States, Colorado ... more >> Denver, Colorado, United States Collapse << |
| NCT01685801 | - | - | Completed | - | - |
| NCT02823470 | Cystic Fibrosis | Phase 4 | Terminated(Study terminated ea... more >>rly due to slow recruitment of patients.) Collapse << | - | United States, Connecticut ... more >> Hartford, Connecticut, United States United States, District of Columbia Washington, District of Columbia, United States United States, Florida Orlando, Florida, United States United States, Georgia Atlanta, Georgia, United States United States, Mississippi Jackson, Mississippi, United States United States, New Mexico Albuquerque, New Mexico, United States United States, South Carolina Columbia, South Carolina, United States Canada, Alberta Edmonton, Alberta, Canada Canada, British Columbia Victoria, British Columbia, Canada Canada, New Brunswick Saint John, New Brunswick, Canada Canada Quebec, Canada Collapse << |
| NCT02823470 | - | - | Terminated(Study terminated ea... more >>rly due to slow recruitment of patients.) Collapse << | - | - |
| NCT02015507 | Cystic Fibrosis | Phase 1 | Completed | - | - |
| NCT02544451 | Cystic Fibrosis | Phase 3 | Active, not recruiting | November 2019 | - |
| NCT01897233 | Cystic Fibrosis | Phase 3 | Completed | - | - |
| NCT01897233 | - | - | Completed | - | - |
| NCT01899105 | Cystic Fibrosis | Phase 1 | Completed | - | United States, Florida ... more >> Daytona, Florida, United States Collapse << |
| NCT02742519 | - | - | Terminated(Low enrollment.) | - | - |
| NCT01614470 | Cystic Fibrosis | Phase 3 | Completed | - | United States, Florida ... more >> Tampa, Florida, United States United States, Georgia Atlanta, Georgia, United States United States, Illinois Chicago, Illinois, United States United States, Massachusetts Boston, Massachusetts, United States United States, Michigan Ann Arbor, Michigan, United States United States, Minnesota Minneapolis, Minnesota, United States United States, Missouri St. Louis, Missouri, United States United States, Texas Houston, Texas, United States Belgium Leuven, Belgium France Lyon, France Montpellier, France Paris, France Collapse << |
| NCT02653027 | Diabetes Cyst... more >>ic Fibrosis Collapse << | Not Applicable | Withdrawn(We couldn't find any... more >> eligible subjects for the study because most of the study population had already started on the combination therapy.) Collapse << | - | - |
| NCT01614470 | - | - | Completed | - | - |
| NCT02742519 | Cystic Fibrosis | Phase 3 | Terminated(Low enrollment.) | - | Australia, Victoria ... more >> Parkville, Victoria, Australia Australia South Brisbane, Australia Subiaco, Australia Westmead, Australia Canada, Ontario Toronto, Ontario, Canada United Kingdom London, United Kingdom Collapse << |
| NCT02412111 | Cystic Fibrosis | Phase 3 | Completed | - | - |
| NCT02565914 | Cystic Fibrosis | Phase 3 | Enrolling by invitation | September 2019 | - |
| NCT02858843 | Cystic Fibrosis ... more >> Diabetes Collapse << | Not Applicable | Terminated(We were unable to e... more >>nroll eligible subjects for the study.) Collapse << | - | - |
| NCT03068312 | Cystic Fibrosis | Phase 3 | Active, not recruiting | December 2018 | Israel ... more >> Hadassah Medical Organization Jerusalem, Israel Collapse << |
| NCT03512119 | - | - | Recruiting | October 10, 2018 | France ... more >> Hôpitaux Universitaires de Strasbourg Recruiting Strasbourg, Alsace, France, 67000 Contact: Laurence KESSLER Principal Investigator: Laurence KESSLER, MD Centre Hospitalier Universitaire d'Angers Recruiting Angers, France, 49033 Contact: Françoise TROUSSIER Principal Investigator: Françoise TROUSSIER Hôpital Renée Sabran Recruiting Giens, France, 83406 Contact: Laurent MELY Principal Investigator: Laurent MELY Centre Hospitalier Lyon Sud Recruiting Lyon, France, 69000 Contact: Isabelle DURIEU Principal Investigator: Isabelle DURIEU Hôpital NORD - Assistance Publique Hôpitaux de Marseille Recruiting Marseille, France, 13385 Contact: Bérengère COLTEY Principal Investigator: Bérengère COLTEY Hôpital Arnaud de Villeneuve Recruiting Montpellier, France, 34295 Contact: Raphael CHIRON Principal Investigator: Raphael CHIRON Hôpital Robert Debré Recruiting Paris, France, 75019 Contact: Michèle GERARDIN Principal Investigator: Michèle GERARDIN American Memorial Hospital Recruiting Reims, France, 51092 Contact: Michel ABLEY Principal Investigator: Michel ABELY Clinique "Mucoviscidose" Presqu'île de Perharidy Recruiting Roscoff, France, 29684 Contact: Gilles RAULT Principal Investigator: Gilles RAULT Hôpital Charles Nicolle Recruiting Rouen, France, 76031 Contact: Stéphane DOMINIQUE Principal Investigator: Stéphane DOMINIQUE Hôpital FOCH Recruiting Suresnes, France, 92151 Contact: Florence BOUILLOUD Principal Investigator: Florence BOUILLOUD Hôpital Bretonneau - CHRU de Tours Recruiting Tours, France, 37044 Contact: Julie MANKIKIAN Principal Investigator: Julie MANKIKIAN Hôpital de Clocheville - CHRU de Tours Recruiting Tours, France, 37044 Contact: Laure COSSON Principal Investigator: Laure COSSON Collapse << |
| NCT02310789 | - | - | Completed | - | - |
| NCT03251911 | Chronic Bronchitis | Phase 4 | Not yet recruiting | February 1, 2021 | United States, Alabama ... more >> University of Alabama at Birmingham Not yet recruiting Birmingham, Alabama, United States, 35233 Contact: Heather Hathorne, PhD 205-638-9568 hhathorne@peds.uab.edu Contact: Ginger Reeves, BS 205-638-5970 greeves@peds.uab.edu Collapse << |
| NCT02807415 | - | - | Recruiting | June 2019 | Germany ... more >> Justus-Liebig-University Recruiting Gießen, Germany, 35385 Contact: Lutz Nährlich, MD 004964198557620 lutz.naehrlich@paediat.med.uni-giessen.de Contact: Claudia Rückes-Nilges, Dipl-Biol 004964198556945 claudia.rueckes-nilges@paediat.med.uni-giessen.de Principal Investigator: Lutz Nährlich, MD Sub-Investigator: Stefan Kuhnert, MD Hannover Medical School Recruiting Hannover, Germany, 30625 Contact: Burkhard Tümmler, MD PhD 00495115322920 tuemmler.burkhard@mh-hannover.de Contact: Christian Dopfer, MD 00495115326111 dopfer.christian@mh-hannover.de Principal Investigator: Burkhard Tümmler, MD PhD Sub-Investigator: Christian Dopfer, MD University of Heidelberg Recruiting Heidelberg, Germany, 69120 Contact: Marcus Mall, MD 00496221564502 Marcus.Mall@med.uni-heidelberg.de Contact: Simon Gräber, MD 004962215638926 Simon.Graeber@med.uni-heidelberg.de Principal Investigator: Marcus Mall, MD Sub-Investigator: Simon Gräber, MD Sub-Investigator: Susanne Dittrich, MD Collapse << |
| NCT01614457 | Cystic Fibrosis | Phase 3 | Completed | - | - |
| NCT01946412 | Cystic Fibrosis | Phase 3 | Completed | - | United States, Alabama ... more >> Birmingham, Alabama, United States United States, Colorado Denver, Colorado, United States United States, Georgia Atlanta, Georgia, United States United States, Indiana Indianapolis, Indiana, United States United States, Massachusetts Boston, Massachusetts, United States United States, Michigan Grand Rapids, Michigan, United States United States, Minnesota Minneapolis, Minnesota, United States United States, Missouri Kansas city, Missouri, United States United States, Nebraska Omaha, Nebraska, United States United States, Utah Salt Lake City, Utah, United States United States, Virginia Richmond, Virginia, United States United States, Washington Seattle, Washington, United States Canada, British Columbia Vancouver, British Columbia, Canada United Kingdom Edinburgh, United Kingdom Liverpool, United Kingdom London, United Kingdom Collapse << |
| NCT01946412 | - | - | Completed | - | - |
| NCT02725567 | Cystic Fibrosis | Phase 3 | Recruiting | June 2020 | - |
| NCT02310789 | Cystic Fibrosis | Not Applicable | Completed | - | United States, California ... more >> Stanford Hospital and Clinics Stanford, California, United States, 94305 Collapse << |
| NCT02934698 | Cystic Fibrosis | Phase 3 | Completed | - | - |
| NCT02934698 | - | - | Completed | - | - |
| NCT02135432 | Chronic Obstructive Pulmonary ... more >>Disease Collapse << | Early Phase 1 | Completed | - | United States, Alabama ... more >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35233 Collapse << |
| NCT03475381 | - | - | Active, not recruiting | June 30, 2018 | France ... more >> Adult CF center, Service de Pneumologie, Cochin Hospital Paris, France, 75006 Collapse << |
| NCT01614457 | - | - | Completed | - | - |
| NCT02135432 | - | - | Completed | - | - |
| NCT01707290 | - | - | Completed | - | - |
| NCT01705145 | Cystic Fibrosis | Phase 3 | Completed | - | - |
| NCT03439865 | Chronic Rhinosinusitis (Diagno... more >>sis) Collapse << | Early Phase 1 | Not yet recruiting | July 2022 | United States, Alabama ... more >> University of Alabama at Birmingham Not yet recruiting Birmingham, Alabama, United States, 35233 Contact: Lisa Clemons, MSN, RN 205-934-9714 lkclemons@uabmc.edu Principal Investigator: Brad Woodworth, MD Collapse << |
| NCT01784419 | Cystic Fibrosis | Not Applicable | Unknown | December 2015 | United States, California ... more >> University of California, San Francisco Recruiting San Francisco, California, United States, 94143 Contact: Dennis Nielson, MD, PhD 415-476-2072 nielsond@peds.ucsf.edu Contact: Dennis W Nielson, MD. PhD 415-476-2072 nielsond@peds.ucsf.edu Principal Investigator: Dennis W Nielson, MD, PhD Sub-Investigator: Meghan McGarry, MD Sub-Investigator: Ngoc Ly, MD, MPH Sub-Investigator: Mary Ellen Kleinhenz, MD Collapse << |
| NCT02194881 | - | - | Completed | - | France ... more >> Hôpital Cochin Paris, France, 75014 Collapse << |
| NCT01707290 | Cystic Fibrosis | Phase 3 | Completed | - | - |
| NCT03085485 | Chronic Obstructive Pulmonary ... more >>Disease Chronic Bronchitis Collapse << | Phase 2 | Recruiting | April 2019 | United States, Alabama ... more >> UAB Lung Health Center Recruiting Birmingham, Alabama, United States, 35294 Contact: Mark T Dransfield, MD 205-934-5555 Principal Investigator: Mark T Dransfield, MD Collapse << |
| NCT01705145 | - | - | Completed | - | - |
| NCT03277196 | Cystic Fibrosis | Phase 3 | Recruiting | June 7, 2021 | - |
| 靶点 | Description | IC50 |
|---|---|---|
| CFTR (F508del) | EC50:25nM | |
| CFTR (G551D) | EC50:100nM |
