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CAS No.: 56092-81-0

Ionomycin/离子霉素 Catalog No. CSN22905

Synonyms: SQ23377

Ionomycin is a calcium ionophore and an antibiotic produced by Streptomyces conglobatus.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Ionomycin is a calcium ionophore and an antibiotic produced by Streptomyces conglobatus. The divalent cation selectivity order for ionomycin was Ca > Mg >> Sr = Ba^[1]. Ionomycin at concentrations of 1-5μM induced the proliferation of highly purified human T cells in the presence of monocytes, associated with enhanced IL-2R expression and IL-2 synthesis. Ionomycin at 2μM induced the hydrolysis of phosphoinositides in purified T cells. Treatment of T cells with ionomycin (2μM) also induced the activation of protein kinase C^[2]. Ionomycin at a concentration of 10µmol/L activated mouse oocytes and resulted in acceptable blastocyst development^[3]. Administration of ionomycin (3mg/kg, i.p. injection, once daily) for 14 days improved hyperglycemia and insulin resistance, but reduced side effects compared with thiazolidinedione in a mouse model of diabetes. Ionomycin treatment also effectively inhibited cyclin-dependent kinase 5-mediated phosphorylation of PPARγ at Ser273 in vivo^[4].
作用机制Ionomycin is a potent and selective calcium ionophore capable of binding and carrying Ca²⁺ across a solvent barrier^[1].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02600988	Hematopoietic Stem Cell Transp... more >>lantation Collapse <<	Phase 1 Phase 2	Completed	-	Spain ... more >> Christelle Ferrà i Coll Badalona, Barcelona, Spain Raquel Saldaña Moreno Jerez de la Frontera, Cádiz, Spain Carmen Martínez Barcelona, Spain David Valcárcel Ferreiras Barcelona, Spain Manuel Jurado Chacón Granada, Spain Mª Ángeles Cuesta Málaga, Spain Fermín Martín Sánchez- Guijo Salamanca, Spain Collapse <<
NCT02137876	-	-	Withdrawn(Subject recruitment ... more >>was unsuccessful.) Collapse <<	-	United States, Illinois ... more >> Northwestern University Comprehensive Transplant Center Chicago, Illinois, United States, 60611 Collapse <<
NCT02686827	Hypersensitivity	Phase 2	Completed	-	Netherlands ... more >> Academic medical center Amsterdam, Netherlands, 1100 AZ Collapse <<

更多
参考文献

[1] Liu C, Hermann TE. Characterization of ionomycin as a calcium ionophore. J Biol Chem. 1978 Sep 10;253(17):5892-4
[2] Chatila T, Silverman L, Miller R, Geha R. Mechanisms of T cell activation by the calcium ionophore ionomycin. J Immunol. 1989 Aug 15;143(4):1283-9
[3] Heytens E, Soleimani R, Lierman S, De Meester S, Gerris J, Dhont M, Van der Elst J, De Sutter P. Effect of ionomycin on oocyte activation and embryo development in mouse. Reprod Biomed Online. 2008 Dec;17(6):764-71. doi: 10.1016/s1472-6483(10)60403-8
[4] Zheng W, Feng X, Qiu L, Pan Z, Wang R, Lin S, Hou D, Jin L, Li Y. Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor γ (PPARγ) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes. Diabetologia. 2013 Feb;56(2):401-11. doi: 10.1007/s00125-012-2777-9

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.4104 mL
- 7.0521 mL
- 14.1043 mL
- 5 mM
- 0.2821 mL
- 1.4104 mL
- 2.8209 mL
- 10 mM
- 0.1410 mL
- 0.7052 mL
- 1.4104 mL

技术信息

CAS号	56092-81-0	储存条件	粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C41H72O9	运输	蓝冰
分子量	709.01	别名	SQ23377

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02600988	Hematopoietic Stem Cell Transp... more >>lantation Collapse <<	Phase 1 Phase 2	Completed	-	Spain ... more >> Christelle Ferrà i Coll Badalona, Barcelona, Spain Raquel Saldaña Moreno Jerez de la Frontera, Cádiz, Spain Carmen Martínez Barcelona, Spain David Valcárcel Ferreiras Barcelona, Spain Manuel Jurado Chacón Granada, Spain Mª Ángeles Cuesta Málaga, Spain Fermín Martín Sánchez- Guijo Salamanca, Spain Collapse <<
NCT02137876	-	-	Withdrawn(Subject recruitment ... more >>was unsuccessful.) Collapse <<	-	United States, Illinois ... more >> Northwestern University Comprehensive Transplant Center Chicago, Illinois, United States, 60611 Collapse <<
NCT02686827	Hypersensitivity	Phase 2	Completed	-	Netherlands ... more >> Academic medical center Amsterdam, Netherlands, 1100 AZ Collapse <<
NCT02045914	Fertilization Failure	Not Applicable	Unknown	August 2014	Turkey ... more >> baskent university obstetric and gynecology, reproductive endocrinology and IVF unit Recruiting Adana, Kisla, Turkey, 01230 Contact 903224597249 Principal Investigator: pinar caglar aytac Collapse <<
NCT03678610	Infertility	Not Applicable	Recruiting	January 15, 2019	Egypt ... more >> Banon Assiut Recruiting Assiut, Egypt Contact: Mai Emad, BsC +201011122286 drfawzy001@gmail.com Sub-Investigator: Mai Emad, BSc Qena Fertility Center Recruiting Qena, Egypt, 123456 Contact: Abobkr Shabib, MD +201011122286 drfawzy001@gmail.com IbnSina IVF Center Recruiting Sohag, Egypt Contact: Mohamed Fawzy, IVF Lab Director +201011122286 drfawzy001@me.com Collapse <<
NCT00657891	Asthma	Phase 4	Completed	-	United States, Nebraska ... more >> Creighton University Medical Center Omaha, Nebraska, United States, 68131 Collapse <<

Ionomycin/离子霉素 Catalog No. CSN22905

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