|胰岛素(牛)|CsnPharm

CAS No.: 11070-73-8

牛胰岛素 Catalog No. CSN23730

Synonyms: Insulin from bovine pancreas;牛胰岛素

Insulin, Bovine is a two-chain polypeptide hormone produced by the β-cells of pancreatic islets, it regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.

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技术信息

生物活性

描述Insulin, Bovine is a two-chain polypeptide hormone produced in vivo in the pancreatic β cells. Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates glucose uptake into muscle and fat cells by recruiting membrane glucose transporter Glut-4 to cell surface. Insulin cattle has often been used as growth supplement in culturing cells at the concentration ranging from 1 to 10 μg/mL of medium^[1]. A stability experiment on purified crystalline bovine insulin showed that it deteriorates at normal refrigeration temperature (5 degrees C) and that storage at -20 degrees C is necessary to ensure stability. Purified insulin degrades by two mechanisms: deamidation and polymerization. Immunochemical potency determinations alone are insufficient to determine the stability of insulin as they may be little affected by the chemical changes which occur on storage. The activation energy for the polymerization of insulin was found to be 66 kJ/mol and for deamidation 45 kJ/mol. It is recommended that crystalline bovine insulin be stored at -20 degrees C^[2].
参考文献

[1] Yousefi R, Taheri B, Alavi P, et al. Aspirin-mediated acetylation induces structural alteration and aggregation of bovine pancreatic insulin. J Biomol Struct Dyn. 2016;34(2):362-375
[2] Fisher BV, Porter PB. Stability of bovine insulin. J Pharm Pharmacol. 1981;33(4):203-206

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.1744 mL
- 0.8721 mL
- 1.7441 mL
- 5 mM
- 0.0349 mL
- 0.1744 mL
- 0.3488 mL
- 10 mM
- 0.0174 mL
- 0.0872 mL
- 0.1744 mL

技术信息

CAS号	11070-73-8	储存条件	粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C254H377N65O75S6	运输	蓝冰
分子量	5733.49	别名	Insulin from bovine pancreas;牛胰岛素

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