6556-11-2|Inositol Nicotinate|CsnPharm

CAS No.: 6556-11-2

Inositol nicotinate Catalog No. CSN21920

Synonyms: 肌醇烟酸酯;Inositol niacinate;Hexanicit

Inositol Nicotinate is a formulation of niacin, which is also called vitamin B3, an essential human nutrient.

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400-920-2911

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生物活性

描述Inositol nicotinate is a form of niacin, also known as vitamin B3, which is an essential nutrient for the human body. Inositol nicotinate has the effect of lowering cholesterol and dilating peripheral blood vessels. It is used in hypercholesterolemia and atherosclerosis. The thermographic index for both the dorsum of the hand and the fingers was significantly lower in the patients with Raynaud's. Oral treatment with inositol nicotinate (Hexopal) was followed by an initial rise in the thermographic index in both areas. Long-term treatment with nicotinate acid derivatives may produce improvement in the peripheral circulation by a different mechanism than the transient effect detected by short-term studies^[1]. Recording the time required to induce Raynaud's phenomenon as well as assessments of total and nutrient digital blood flow showed significant beneficial therapeutic effects upon the skin's microcirculation by inositol nicotinate. Unlike some other drugs in this field inositol nicotinate was found to be effective orally and to be devoid of unwanted side-effects^[2].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01139398	Delivery of Health Care	Not Applicable	Completed	-	France ... more >> Biofortis Nantes, France, 44200 Collapse <<
NCT03630991	Acute Myeloid Leukemia ... more >> Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome Chronic Myelogenous Leukemia, BCR-ABL1 Positive Chronic Myelomonocytic Leukemia Myelodysplastic Syndrome Myelodysplastic/Myeloproliferative Neoplasm Secondary Acute Myeloid Leukemia Collapse <<	Phase 2	Recruiting	December 31, 2020	United States, Texas ... more >> M D Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact mohanian@mdanderson.org Collapse <<
NCT01488656	Inflammation	Not Applicable	Completed	-	-

参考文献

[1] Ring EF, Bacon PA. Quantitative thermographic assessment of inositol nicotinate therapy in Raynaud's phenomena. J Int Med Res. 1977;5(4):217-22
[2] Holti G. An experimentally controlled evaluation of the effect of inositol nicotinate upon the digital blood flow in patients with Raynaud's phenomenon. J Int Med Res. 1979;7(6):473-83

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2335 mL
- 6.1674 mL
- 12.3347 mL
- 5 mM
- 0.2467 mL
- 1.2335 mL
- 2.4669 mL
- 10 mM
- 0.1233 mL
- 0.6167 mL
- 1.2335 mL

技术信息

CAS号

6556-11-2

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C42H30N6O12

运输

蓝冰

分子量

810.72

别名

肌醇烟酸酯;Inositol niacinate;Hexanicit

溶解度

DMSO	29.29 mg/mL (36.1 mM)
Water	insoluble

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