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CAS No.: 771-50-6

Indole-3-carboxylic acid/吲哚-3-羧酸 Catalog No. CSN23591

Synonyms: 3-Indoleformic acid;3-Carboxyindole;β-Indolylcarboxylic acid

Indole-3-carboxylic Acid is a normal urinary indolic tryptophan metabolite with multiple biological roles such as serotonin 5-HT4/6 receptor antagonist, EphB3 receptor tyrosine kinase inhibitor, vinyl ester pseudotripeptide proteasome inhibitor and potential therapeutic agent for Alzheimer′s Disease.

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技术信息

生物活性

描述Indole-3-carboxylic acid is a normal urinary indolic tryptophan metabolite and has been found elevated in patients with liver diseases^[2]. A novel series of 1H-indole-3-carboxylic acid pyridine-3-ylamides were synthesized and identified to show high affinity and selectivity for 5-HT(2C) receptor. Among them, 1H-indole-3-carboxylic acid[6-(2-chloro-pyridin-3-yloxy)-pyridin-3-yl]-amide (15k) exhibits the highest affinity (IC50=0.5 nM) with an excellent selectivity (>2000 times) over other serotonin (5-HT(1A), 5-HT(2A), and 5-HT(6)) and dopamine (D(2)-D(4)) receptors^[3]. After oral administration to mice, I3C (Indole-3-carbinol), in addition to its acid condensation products, is absorbed from the gut and distributed systemically into a number of well-perfused tissues, thus allowing the possibility for some pharmacological activity of the parent compound in vivo^[4].
参考文献

[2] Byrd DJ, Kochen W, Idzko D, Knorr E. The analysis of indolic tryptophan metabolites in human urine. Thin-layer chromatography and in situ quantitation. J Chromatogr. 1974 Jul 17;94(0):85-106
[3] Park CM, Kim SY, Park WK, Park NS, Seong CM. Synthesis and structure-activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: a novel series of 5-HT2C receptor antagonists. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3844-7
[4] Anderton MJ, Manson MM, Verschoyle RD, Gescher A, Lamb JH, Farmer PB, Steward WP, Williams ML. Pharmacokinetics and tissue disposition of indole-3-carbinol and its acid condensation products after oral administration to mice. Clin Cancer Res. 2004 Aug 1;10(15):5233-41

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.2050 mL
- 31.0251 mL
- 62.0501 mL
- 5 mM
- 1.2410 mL
- 6.2050 mL
- 12.4100 mL
- 10 mM
- 0.6205 mL
- 3.1025 mL
- 6.2050 mL

技术信息

CAS号

771-50-6

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H7NO2

运输

蓝冰

分子量

161.16

别名

3-Indoleformic acid;3-Carboxyindole;β-Indolylcarboxylic acid;3-indolecarboxylate;3-indoleformate;1H-Indole-3-carboxylic acid;Indole-3-carboxylic Acid;I3CA;ICOOH;Indole-β-carboxylic Acid;吲哚-3-羧酸

溶解度

DMSO	95.0 mg/mL (589.5 mM) warming

动物实验配方

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Indole-3-carboxylic acid/吲哚-3-羧酸 Catalog No. CSN23591

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