CAS No.: 677331-12-3
iCRT 14 Catalog No. CSN16814
Synonyms: Wnt inhibitor
iCRT 14 is a potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Thought to directly influence the interaction between β-catenin and TCF4. Induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Bilir B, Kucuk O, et al. Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells. J Transl Med. 2013 Nov 4;11:280.
- [2] Gonsalves FC, Klein K, et al. An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):5954-63.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 677331-12-3 | 储存条件 |
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| 分子式 | C21H17N3O2S | 运输 | 蓝冰 | |||||||
| 分子量 | 375.44 | 别名 | Wnt inhibitor | |||||||
| 溶解度 |
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动物实验配方 |
