|3,5-二羟基-2-(4-甲氧基苯基)-8-(3-甲基丁-2-烯-1-基)-7-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-4H-苯并吡喃-4-酮|CsnPharm

CAS No.: 56725-99-6

Icariside I/淫羊藿次苷 Catalog No. CSN13609

Synonyms: Icarisid I;淫羊藿次苷I

Icariside I is a natural product isolated and purified from the herbs of Epimedium brevicornu.

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400-920-2911

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技术信息

生物活性

描述Icariside I is a metabolite of Icarlin, which could regulate bone remodeling and is recognized as an effective agent for the treatment of osteoporosis^[2]. Icariin, whose metabolites include icariside I, icariside II, icaritin, and desmethylicaritin, has no estrogenic activity. However, icariin is more potent than genistein in promoting osteogenic differentiation and maturation of osteoblasts^[3]. Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity^[4]. Icariside I improves the levels of microbiota-derived metabolites such as short-chain fatty acids (SCFAs) and indole derivatives, consequently promoting repair of the intestinal barrier and reducing systemic inflammation of tumor-bearing mice. Icariside I exhibited strong immunological anti-tumor activity, directly manifested by up-regulation of multiple lymphocyte subsets including CD4+ and CD8+ T cells or NK and NKT cells in peripheral blood of tumor-bearing mice^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8849 mL
- 9.4247 mL
- 18.8494 mL
- 5 mM
- 0.3770 mL
- 1.8849 mL
- 3.7699 mL
- 10 mM
- 0.1885 mL
- 0.9425 mL
- 1.8849 mL

技术信息

CAS号

56725-99-6

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C27H30O11

运输

蓝冰

分子量

530.52

别名

Icarisid I;淫羊藿次苷I

溶解度

DMSO	73.0 mg/mL (137.6 mM) warming

动物实验配方

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