CAS No.: 313254-51-2
ICA-121431 Catalog No. CSN18204
ICA-121431 is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, but no inhibition on human, monkey and dog Nav1.7.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Osteen JD, Sampson K, et al. Pharmacology of the Na(v)1.1 domain IV voltage sensor reveals coupling between inactivation gating processes. Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6836-6841.
- [2] McCormack K, Santos S, et al. Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):E2724-32.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 313254-51-2 | 储存条件 |
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| 分子式 | C23H19N3O3S2 | 运输 | 蓝冰 | |||||
| 分子量 | 449.55 | 别名 | ||||||
| 溶解度 |
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动物实验配方 |
