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CAS No.: 2552-55-8

Ibotenic acid/鹅膏氨酸 Catalog No. CSN21125

Synonyms: (RS)-Ibotenic acid;DL-Ibotenic acid;NSC 204850

Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites.

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技术信息

生物活性

描述Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites. Ibotenic acid (Ibo) is capable of acting at both NMDA and trans-ACPD receptors in the CNS, although only activation of NMDA receptors is involved in Ibo neurotoxicity. Ibotenic acid is toxic to cortical neurons exposes for 5 min with an EC50=77.3±8 μM (n=5) as measured by release of lactate dehydrogenase to the culture media^[3]. Ibotenic acid was inhibitors of (S)-glutamic acid decarboxylase (GAD) in mouse brain homogenates, and was shown to undergo decarboxylation during incubation with brain homogenates. The formation of the decarboxylated product, muscimol, which primarily occurred in a synaptosomal fraction, was dependent on the presence of pyridoxal-5-phosphate (PALP) and was inhibited by (S)-glutamic acid, 3-mercaptopropionic acid (3MPA), aminooxyacetic acid (AOAA), and allyglycine, suggesting that ibotenic acid is a substrate for GAD. The overall decomposition rate for ibotenic acid (8.7 nmol min-1 mg-1 of protein), which apparently embraces other reactions in addition to decarboxylation to muscimol, was higher than the rate of decarboxylation of (S)-glutamic acid (3.2 nmol min-1 mg-1 of protein)^[4]. Ibotenic acid induced similar neuronal migration impairments in control and alcohol-exposed pups (nodular heterotopia in the white matter and/or deep cortical layers, subpial ectopia, and micro- or polymicrogyria)^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00005925	Epilepsy	Phase 1	Terminated	-	United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse <<
NCT00921128	Parkinson's Disease	Phase 1	Withdrawn	-	-

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.3246 mL
- 31.6231 mL
- 63.2463 mL
- 5 mM
- 1.2649 mL
- 6.3246 mL
- 12.6493 mL
- 10 mM
- 0.6325 mL
- 3.1623 mL
- 6.3246 mL

技术信息

CAS号

2552-55-8

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C5H6N2O4

运输

蓝冰

分子量

158.11

别名

(RS)-Ibotenic acid;DL-Ibotenic acid;NSC 204850;Ibotenic Acid;Ibotenate;石蜡酸

溶解度

DMSO	5.0 mg/mL (31.6 mM) warming
Water	5.0 mg/mL (31.6 mM) warming

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