|1-((4-羟基-1-(苯基甲基)-4-哌啶基)甲基)-2(1H)-吡啶酮盐酸盐|CsnPharm

CAS No.: 1339058-04-6

Hypidone HCl Catalog No. CSN18999

Synonyms: YL0919

YL0919 is a dual 5-HT1A partial agonist and SSRI, producing antidepressant- and anxiolytic-like effects.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 SSRIs (rat)

IC50:1.78±0.34nM SSRIs

IC50:1.93±0.18nM
描述YL0919 is a 5-HT1A receptor agonist and a selective serotonin reuptake inhibitor with IC50 values of 1.78 ± 0.34 nM(rat cerebral cortical synaptosomes) and 1.93 ± 0.18 nM(human recombinant cells)^[3]. In vivo, YL0919 (1.25 - 2.5 mg/kg) significantly decreased the immobility time in both the tail suspension test and the forced swim test in a dose-dependent manner, demonstrating the antidepressant-like effect of YL-0919. In vitro, YL0919 (10^-9 - 10^-5 mol/L) was also shown to activate AC in a dose-dependent manner in synaptic membranes extracted from the rat prefrontal cortex, and this effect (10^-7 - 10^-5 mol/L) was antagonized by WAY-100635 (10^-7 mol/L)^[4].
参考文献

[1] Qin JJ, Chen HX, et al. The role of activation of the 5-HT1A receptor and adenylate cyclase in the antidepressant-like effect of YL-0919, a dual 5-HT1A agonist and selective serotonin reuptake inhibitor. Neurosci Lett. 2014 Oct 17;582:104-8.
[2] Chen HX, Jin ZL, et al. Antidepressant-like activity of YL-0919: a novel combined selective serotonin reuptake inhibitor and 5-HT1A receptor agonist. PLoS One. 2013 Dec 18;8(12):e83271.
[3] Chen HX, Jin ZL, Zhang LM, et al. Antidepressant-like activity of YL-0919: a novel combined selective serotonin reuptake inhibitor and 5-HT1A receptor agonist. PLoS One. 2013;8(12):e83271. Published 2013 Dec 18.
[4] Qin JJ, Chen HX, Zhao N, et al. The role of activation of the 5-HT1A receptor and adenylate cyclase in the antidepressant-like effect of YL-0919, a dual 5-HT1A agonist and selective serotonin reuptake inhibitor. Neurosci Lett. 2014;582:104-108.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9865 mL
- 14.9325 mL
- 29.8650 mL
- 5 mM
- 0.5973 mL
- 2.9865 mL
- 5.9730 mL
- 10 mM
- 0.2986 mL
- 1.4932 mL
- 2.9865 mL

技术信息

CAS号

1339058-04-6

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H23ClN2O2

运输

蓝冰

分子量

334.84

别名

YL0919

溶解度

DMSO	30.0 mg/mL (89.6 mM)

动物实验配方

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靶点	Description	IC50
SSRIs (rat)		IC50:1.78±0.34nM
SSRIs		IC50:1.93±0.18nM

Hypidone HCl Catalog No. CSN18999

靶点选择性

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