|4,5,7,4',5',7'-六羟基-2,2'-二甲基萘并二蒽酮 P-conformer|CsnPharm

CAS No.: 548-04-9

Hypericin/金丝桃素 Catalog No. CSN12612

Synonyms: Hyp;HY;NSC 407313

Hypericin, a natural product isolated and purified from the herb of Hypericum perforatum L., is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Hypericin, a powerful naturally occurring photosensitizer, is found in Hypericum perforatum plants, commonly known as St. John's wort. Hypericin can induce both apoptosis and necrosis in a concentration and light dose-dependent fashion^[3]. Among its antidepressant and light-dependent antiviral actions, hypericin is a powerful natural photosensitizer that is applicable in the photodynamic therapy (PDT) of various oncological diseases. In addition, light-activated hypericin acts as a strong pro-oxidant agent with antineoplastic and antiangiogenic properties, since it effectively induces the apoptosis, necrosis or autophagy of cancer cells. Moreover, a strong affinity of hypericin for necrotic tissue was discovered^[4]. Hypericin significantly decreased the minimum inhibitory concentrations of β-lactam antibiotics (e.g., oxacillin, cefazolin and nafcillin), biofilm formation and fibronectin binding in MRSA strain JE2^[5]. In vivo, prophylactic or therapeutic use of hypericin inhibited islet β-cell apoptosis and enhanced the anti-oxidative ability of pancreatic tissue in high-fat/high-sucrose (HFHS)-fed mice, thus alleviating β-cell loss and maintaining or improving β-cell mass and islet size. More importantly, hypericin treatment decreased fasting blood glucose, improved glucose intolerance and insulin intolerance, and alleviated HFHS-fed mice^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01726764	Type 2 Diabetes ... more >> Depression Collapse <<	Phase 1	Completed	-	Denmark ... more >> Department of Clinical Pharmacology, Institute of Public Health, University of Southern Denmark Odense, Denmark, DK-5000 Collapse <<
NCT02862236	Subclinical Anxious Adults ... more >> Nootropic Potential of Hypericum and Alprazolam Healthy Adults Collapse <<	Phase 4	Completed	-	Israel ... more >> Technion, Israel Institute of Technology Haifa, Israel Collapse <<
NCT00000792	HIV Infections	Phase 1	Completed	-	United States, Maryland ... more >> Johns Hopkins Adult AIDS CRS Baltimore, Maryland, United States, 21287 United States, Massachusetts Beth Israel Deaconess - East Campus A0102 CRS Boston, Massachusetts, United States, 02215 United States, New York NY Univ. HIV/AIDS CRS New York, New York, United States, 10016 Collapse <<

更多
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9824 mL
- 9.9119 mL
- 19.8238 mL
- 5 mM
- 0.3965 mL
- 1.9824 mL
- 3.9648 mL
- 10 mM
- 0.1982 mL
- 0.9912 mL
- 1.9824 mL

技术信息

CAS号	548-04-9	储存条件	粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C30H16O8	运输	蓝冰
分子量	504.44	别名	Hyp;HY;NSC 407313;SGX-301;NSC 622946;hypericin;金丝桃素

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01726764	Type 2 Diabetes ... more >> Depression Collapse <<	Phase 1	Completed	-	Denmark ... more >> Department of Clinical Pharmacology, Institute of Public Health, University of Southern Denmark Odense, Denmark, DK-5000 Collapse <<
NCT02862236	Subclinical Anxious Adults ... more >> Nootropic Potential of Hypericum and Alprazolam Healthy Adults Collapse <<	Phase 4	Completed	-	Israel ... more >> Technion, Israel Institute of Technology Haifa, Israel Collapse <<
NCT00000792	HIV Infections	Phase 1	Completed	-	United States, Maryland ... more >> Johns Hopkins Adult AIDS CRS Baltimore, Maryland, United States, 21287 United States, Massachusetts Beth Israel Deaconess - East Campus A0102 CRS Boston, Massachusetts, United States, 02215 United States, New York NY Univ. HIV/AIDS CRS New York, New York, United States, 10016 Collapse <<
NCT01921881	Type 2 Diabetes	Phase 1	Completed	-	Denmark ... more >> Department of Clinical Pharmacology, Institute of Public Health, University of Southern Denmark Odense C, Denmark, DK-5000 Collapse <<
NCT02840331	Peritoneal Carcinomatosis	Phase 3	Recruiting	July 2020	Germany ... more >> University Department of General, Visceral and Transplant Surgery Recruiting Tübingen, Baden.Württemberg, Germany, 72076 Contact: Stefan Beckert, Prof. Dr. +49-(0)7071-29-86619 stefan.beckert@med.uni-tuebingen.de Contact: Alfred Königsrainer, Prof. Dr. +49-(0)7071-29-86619 alfred.koenigsrainer@med.uni-tuebingen.de Collapse <<
NCT02448381	Cutaneous T-Cell Lymphoma	Phase 3	Recruiting	-	-
NCT00000645	HIV Infections	Phase 1	Completed	-	United States, Massachusetts ... more >> Beth Israel Deaconess - East Campus A0102 CRS Boston, Massachusetts, United States, 02215 United States, Minnesota University of Minnesota, ACTU Minneapolis, Minnesota, United States United States, New York NY Univ. HIV/AIDS CRS New York, New York, United States, 10016 Collapse <<

Hypericin/金丝桃素 Catalog No. CSN12612

靶点选择性

请登录您的专属账户

确认信息