|(1S,4aS,5R,7S,7aS)-4a,5-二羟基-7-甲基-1-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-1,4a,5,6,7,7a-六氢环戊二烯并[c]吡喃-7-基肉桂酸酯|CsnPharm

CAS No.: 19210-12-9

Harpagoside/哈巴俄苷 Catalog No. CSN16185

Synonyms: SMR001233395;Eharpagoside;AC1NQYLY

Harpagoside is a naturally occurring iridoid glycoside with anti-inflammatory effect.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Harpagoside is isolated from Harpagophytum procumbens (Hp). Harpagoside has inhibitory effects on COX-1 and COX-2 activity and inhibits NO production. The highest concentration of harpagoside inhibited indistinctively COX-1 and COX-2 (37.2 and 29.5% respectively) activity and greatly inhibited NO production (66%)^[3]. Harpagoside exerts a significant anti-inflammatory effect by inhibiting the inflammatory stimuli mediated by suppressing c-FOS/AP-1 activity in OA (osteoarthritis) chondrocytes under pathological conditions^[4]. With the use of chronic cerebral hypoperfusion rats, a well-known VaD (Vascular dementia) model, we demonstrated that chronic administration (two months) of harpagoside was able to restore both the spatial learning/memory and fear memory impairments. Harpagoside suppressed the overactivation of PTEN induced by CCH by enhancing PTEN phosphorylation. Furthermore, harpagoside elevated the activity of Akt and inhibited the activity of GSK-3β, downstream effectors of PTEN^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03641248	Osteoarthritis, Knee	Early Phase 1	Not yet recruiting	June 2019	United States, Missouri ... more >> Univ of Missouri Health Care Center Not yet recruiting Columbia, Missouri, United States, 65211 Contact: Dean Hainsworth, MD 573-882-4894 ClinicalResearch@health.missouri.edu Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0223 mL
- 10.1115 mL
- 20.2229 mL
- 5 mM
- 0.4045 mL
- 2.0223 mL
- 4.0446 mL
- 10 mM
- 0.2022 mL
- 1.0111 mL
- 2.0223 mL

技术信息

CAS号

19210-12-9

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H30O11

运输

蓝冰

分子量

494.49

别名

SMR001233395;Eharpagoside;AC1NQYLY;Prestwick3000988;哈巴俄苷

溶解度

DMSO	145.0 mg/mL (293.2 mM)
Water	85.0 mg/mL (171.9 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Harpagoside/哈巴俄苷 Catalog No. CSN16185

靶点选择性

请登录您的专属账户

确认信息